APAF1

 

Full name: apoptotic peptidase activating factor 1 Alias Symbol: CED4|APAF-1
Type: protein-coding gene Cytoband: 12q23.1
Entrez ID: 317 HGNC ID: HGNC:576 Ensembl Gene: ENSG00000120868 OMIM ID: 602233
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

APAF1 involved pathways:

KEGG pathway Description View
hsa04115p53 signaling pathway
hsa04210Apoptosis
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05134Legionellosis
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05222Small cell lung cancer

 

Expression of APAF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 APAF1 317 211554_s_at 0.1513 0.4291
GSE20347 APAF1 317 211554_s_at 0.1203 0.1046
GSE23400 APAF1 317 211554_s_at -0.0732 0.0906
GSE26886 APAF1 317 204859_s_at 0.4902 0.0217
GSE29001 APAF1 317 211554_s_at -0.0045 0.9809
GSE38129 APAF1 317 211554_s_at 0.0899 0.1256
GSE45670 APAF1 317 204859_s_at 0.4129 0.0336
GSE63941 APAF1 317 204859_s_at -0.5587 0.3603
GSE77861 APAF1 317 211554_s_at 0.0528 0.6004
GSE97050 APAF1 317 A_23_P36611 -0.5403 0.2308
SRP007169 APAF1 317 RNAseq 1.4129 0.0006
SRP008496 APAF1 317 RNAseq 0.9118 0.0025
SRP064894 APAF1 317 RNAseq 0.4052 0.1185
SRP133303 APAF1 317 RNAseq 0.3167 0.0180
SRP159526 APAF1 317 RNAseq -0.0072 0.9810
SRP193095 APAF1 317 RNAseq 0.0744 0.5931
SRP219564 APAF1 317 RNAseq 0.0995 0.6917
TCGA APAF1 317 RNAseq -0.0984 0.1165

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by APAF1 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of APAF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 APAF1 317 2 3 25
GSE20123 APAF1 317 2 3 25
GSE43470 APAF1 317 2 0 41
GSE46452 APAF1 317 9 1 49
GSE47630 APAF1 317 9 2 29
GSE54993 APAF1 317 0 5 65
GSE54994 APAF1 317 4 2 47
GSE60625 APAF1 317 0 0 11
GSE74703 APAF1 317 2 0 34
GSE74704 APAF1 317 1 2 17
TCGA APAF1 317 16 10 70

Total number of gains: 47; Total number of losses: 28; Total Number of normals: 413.  

 

Somatic mutations of APAF1:

 

Generating mutation plots.

 

Highly correlated genes for APAF1:

 

Showing top 20/152 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
APAF1GCNT40.704495404
APAF1CDC42EP20.703089303
APAF1TEK0.692745303
APAF1KHDRBS20.686639303
APAF1IFNA160.68639303
APAF1OR6A20.685719303
APAF1TMPRSS50.684797303
APAF1CGA0.667333303
APAF1CITED10.660418303
APAF1KCNJ100.65944303
APAF1ZMAT40.659371404
APAF1SLC6A50.65863303
APAF1GRIP20.654634303
APAF1PPP2R5B0.65456303
APAF1CPNE60.654034404
APAF1GALNT80.646981403
APAF1RILPL20.646492303
APAF1RPS6KA60.644315403
APAF1MPZ0.642286404
APAF1GDNF0.640902403

For details and further investigation, click here