| Full name: ATPase H+ transporting V1 subunit C1 | Alias Symbol: VATC|Vma5 | ||
| Type: protein-coding gene | Cytoband: 8q22.3 | ||
| Entrez ID: 528 | HGNC ID: HGNC:856 | Ensembl Gene: ENSG00000155097 | OMIM ID: 603097 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ATP6V1C1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway | |
| hsa05110 | Vibrio cholerae infection | |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
Expression of ATP6V1C1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATP6V1C1 | 528 | 202874_s_at | 1.1664 | 0.0354 | |
| GSE20347 | ATP6V1C1 | 528 | 202874_s_at | 1.3187 | 0.0000 | |
| GSE23400 | ATP6V1C1 | 528 | 202874_s_at | 1.1726 | 0.0000 | |
| GSE26886 | ATP6V1C1 | 528 | 202872_at | 0.2409 | 0.2307 | |
| GSE29001 | ATP6V1C1 | 528 | 202872_at | 1.4129 | 0.0000 | |
| GSE38129 | ATP6V1C1 | 528 | 202874_s_at | 1.5553 | 0.0000 | |
| GSE45670 | ATP6V1C1 | 528 | 202874_s_at | 1.0318 | 0.0001 | |
| GSE53622 | ATP6V1C1 | 528 | 109803 | 0.9448 | 0.0000 | |
| GSE53624 | ATP6V1C1 | 528 | 109803 | 1.3831 | 0.0000 | |
| GSE63941 | ATP6V1C1 | 528 | 202874_s_at | 0.6893 | 0.0848 | |
| GSE77861 | ATP6V1C1 | 528 | 202874_s_at | 0.9442 | 0.0279 | |
| GSE97050 | ATP6V1C1 | 528 | A_23_P146058 | 0.6673 | 0.1156 | |
| SRP007169 | ATP6V1C1 | 528 | RNAseq | 1.1226 | 0.0014 | |
| SRP008496 | ATP6V1C1 | 528 | RNAseq | 1.1283 | 0.0000 | |
| SRP064894 | ATP6V1C1 | 528 | RNAseq | 1.4072 | 0.0000 | |
| SRP133303 | ATP6V1C1 | 528 | RNAseq | 0.8093 | 0.0000 | |
| SRP159526 | ATP6V1C1 | 528 | RNAseq | 0.6002 | 0.0079 | |
| SRP193095 | ATP6V1C1 | 528 | RNAseq | 0.7707 | 0.0000 | |
| SRP219564 | ATP6V1C1 | 528 | RNAseq | 0.7568 | 0.0374 | |
| TCGA | ATP6V1C1 | 528 | RNAseq | 0.0600 | 0.1968 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by ATP6V1C1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATP6V1C1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATP6V1C1 | 528 | 17 | 0 | 13 | |
| GSE20123 | ATP6V1C1 | 528 | 18 | 0 | 12 | |
| GSE43470 | ATP6V1C1 | 528 | 22 | 0 | 21 | |
| GSE46452 | ATP6V1C1 | 528 | 24 | 0 | 35 | |
| GSE47630 | ATP6V1C1 | 528 | 24 | 0 | 16 | |
| GSE54993 | ATP6V1C1 | 528 | 0 | 20 | 50 | |
| GSE54994 | ATP6V1C1 | 528 | 38 | 1 | 14 | |
| GSE60625 | ATP6V1C1 | 528 | 0 | 4 | 7 | |
| GSE74703 | ATP6V1C1 | 528 | 19 | 0 | 17 | |
| GSE74704 | ATP6V1C1 | 528 | 12 | 0 | 8 | |
| TCGA | ATP6V1C1 | 528 | 59 | 1 | 36 |
Total number of gains: 233; Total number of losses: 26; Total Number of normals: 229.
Somatic mutations of ATP6V1C1:
Generating mutation plots.
Highly correlated genes for ATP6V1C1:
Showing top 20/2073 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATP6V1C1 | ZNF707 | 0.820167 | 3 | 0 | 3 |
| ATP6V1C1 | FADS1 | 0.802274 | 3 | 0 | 3 |
| ATP6V1C1 | PUF60 | 0.801808 | 11 | 0 | 10 |
| ATP6V1C1 | RAB34 | 0.798639 | 3 | 0 | 3 |
| ATP6V1C1 | CCDC127 | 0.798093 | 3 | 0 | 3 |
| ATP6V1C1 | ENY2 | 0.796961 | 13 | 0 | 12 |
| ATP6V1C1 | POLR2K | 0.796033 | 11 | 0 | 11 |
| ATP6V1C1 | TP53RK | 0.795258 | 3 | 0 | 3 |
| ATP6V1C1 | PYCR2 | 0.785597 | 3 | 0 | 3 |
| ATP6V1C1 | MTHFD1L | 0.785371 | 3 | 0 | 3 |
| ATP6V1C1 | EBNA1BP2 | 0.77672 | 3 | 0 | 3 |
| ATP6V1C1 | PSMB2 | 0.776185 | 10 | 0 | 10 |
| ATP6V1C1 | MRPS28 | 0.767952 | 9 | 0 | 8 |
| ATP6V1C1 | RPN1 | 0.763432 | 10 | 0 | 10 |
| ATP6V1C1 | MFAP2 | 0.763228 | 10 | 0 | 10 |
| ATP6V1C1 | LRP12 | 0.762023 | 11 | 0 | 11 |
| ATP6V1C1 | LAPTM4B | 0.761848 | 12 | 0 | 10 |
| ATP6V1C1 | LPCAT1 | 0.759542 | 10 | 0 | 10 |
| ATP6V1C1 | PDIA5 | 0.759529 | 3 | 0 | 3 |
| ATP6V1C1 | SLC45A4 | 0.757367 | 6 | 0 | 6 |
For details and further investigation, click here
