| Full name: methyltransferase like 3 | Alias Symbol: Spo8|M6A|MT-A70 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 56339 | HGNC ID: HGNC:17563 | Ensembl Gene: ENSG00000165819 | OMIM ID: 612472 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of METTL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | METTL3 | 56339 | 209265_s_at | 0.2170 | 0.7625 | |
| GSE20347 | METTL3 | 56339 | 209265_s_at | 0.6034 | 0.0012 | |
| GSE23400 | METTL3 | 56339 | 209265_s_at | 0.9401 | 0.0000 | |
| GSE26886 | METTL3 | 56339 | 209265_s_at | 0.4175 | 0.2150 | |
| GSE29001 | METTL3 | 56339 | 209265_s_at | 0.5540 | 0.0551 | |
| GSE38129 | METTL3 | 56339 | 209265_s_at | 0.5398 | 0.0002 | |
| GSE45670 | METTL3 | 56339 | 209265_s_at | 0.2517 | 0.2383 | |
| GSE53622 | METTL3 | 56339 | 110230 | 0.4738 | 0.0000 | |
| GSE53624 | METTL3 | 56339 | 110230 | 0.5932 | 0.0000 | |
| GSE63941 | METTL3 | 56339 | 209265_s_at | 1.3721 | 0.0086 | |
| GSE77861 | METTL3 | 56339 | 209265_s_at | 0.9271 | 0.0963 | |
| GSE97050 | METTL3 | 56339 | A_33_P3449397 | -0.0155 | 0.9542 | |
| SRP007169 | METTL3 | 56339 | RNAseq | 0.8866 | 0.0541 | |
| SRP008496 | METTL3 | 56339 | RNAseq | 0.4636 | 0.1046 | |
| SRP064894 | METTL3 | 56339 | RNAseq | 0.4029 | 0.0249 | |
| SRP133303 | METTL3 | 56339 | RNAseq | 0.1675 | 0.3254 | |
| SRP159526 | METTL3 | 56339 | RNAseq | 0.2322 | 0.1268 | |
| SRP193095 | METTL3 | 56339 | RNAseq | 0.2846 | 0.0121 | |
| SRP219564 | METTL3 | 56339 | RNAseq | 0.1792 | 0.6285 | |
| TCGA | METTL3 | 56339 | RNAseq | 0.0954 | 0.0886 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by METTL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of METTL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | METTL3 | 56339 | 9 | 3 | 18 | |
| GSE20123 | METTL3 | 56339 | 9 | 3 | 18 | |
| GSE43470 | METTL3 | 56339 | 7 | 2 | 34 | |
| GSE46452 | METTL3 | 56339 | 18 | 2 | 39 | |
| GSE47630 | METTL3 | 56339 | 10 | 10 | 20 | |
| GSE54993 | METTL3 | 56339 | 3 | 11 | 56 | |
| GSE54994 | METTL3 | 56339 | 18 | 5 | 30 | |
| GSE60625 | METTL3 | 56339 | 0 | 2 | 9 | |
| GSE74703 | METTL3 | 56339 | 6 | 2 | 28 | |
| GSE74704 | METTL3 | 56339 | 4 | 2 | 14 | |
| TCGA | METTL3 | 56339 | 27 | 16 | 53 |
Total number of gains: 111; Total number of losses: 58; Total Number of normals: 319.
Somatic mutations of METTL3:
Generating mutation plots.
Highly correlated genes for METTL3:
Showing top 20/1070 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| METTL3 | ANAPC4 | 0.871038 | 3 | 0 | 3 |
| METTL3 | ZNF251 | 0.858632 | 3 | 0 | 3 |
| METTL3 | HAUS2 | 0.821877 | 3 | 0 | 3 |
| METTL3 | SUPT16H | 0.758303 | 13 | 0 | 13 |
| METTL3 | SPIRE2 | 0.754302 | 3 | 0 | 3 |
| METTL3 | METTL17 | 0.739494 | 12 | 0 | 11 |
| METTL3 | CCDC15 | 0.738677 | 3 | 0 | 3 |
| METTL3 | DICER1 | 0.738587 | 3 | 0 | 3 |
| METTL3 | RNASEH2B | 0.73636 | 3 | 0 | 3 |
| METTL3 | MYH3 | 0.730777 | 3 | 0 | 3 |
| METTL3 | APEX1 | 0.727919 | 12 | 0 | 11 |
| METTL3 | RBMX | 0.719248 | 3 | 0 | 3 |
| METTL3 | SLC38A6 | 0.712149 | 7 | 0 | 7 |
| METTL3 | SNRPD3 | 0.698801 | 3 | 0 | 3 |
| METTL3 | FH | 0.697399 | 3 | 0 | 3 |
| METTL3 | LRRC58 | 0.694063 | 3 | 0 | 3 |
| METTL3 | NGDN | 0.690581 | 13 | 0 | 13 |
| METTL3 | FKBP2 | 0.6868 | 3 | 0 | 3 |
| METTL3 | PHOSPHO2 | 0.684041 | 4 | 0 | 3 |
| METTL3 | PARP2 | 0.680526 | 13 | 0 | 10 |
For details and further investigation, click here
