| Full name: protein tyrosine phosphatase non-receptor type 3 | Alias Symbol: PTPH1 | ||
| Type: protein-coding gene | Cytoband: 9q31 | ||
| Entrez ID: 5774 | HGNC ID: HGNC:9655 | Ensembl Gene: ENSG00000070159 | OMIM ID: 176877 |
| Drug and gene relationship at DGIdb | |||
Expression of PTPN3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTPN3 | 5774 | 203997_at | 0.3226 | 0.6659 | |
| GSE20347 | PTPN3 | 5774 | 203997_at | -0.7728 | 0.0001 | |
| GSE23400 | PTPN3 | 5774 | 203997_at | -0.8192 | 0.0000 | |
| GSE26886 | PTPN3 | 5774 | 203997_at | -2.0443 | 0.0000 | |
| GSE29001 | PTPN3 | 5774 | 203997_at | -0.7372 | 0.0467 | |
| GSE38129 | PTPN3 | 5774 | 203997_at | -0.2152 | 0.3837 | |
| GSE45670 | PTPN3 | 5774 | 203997_at | -0.5068 | 0.0570 | |
| GSE53622 | PTPN3 | 5774 | 30519 | -0.5420 | 0.0026 | |
| GSE53624 | PTPN3 | 5774 | 30519 | -0.9777 | 0.0000 | |
| GSE63941 | PTPN3 | 5774 | 203997_at | 2.4677 | 0.0002 | |
| GSE77861 | PTPN3 | 5774 | 203997_at | -0.3974 | 0.1887 | |
| GSE97050 | PTPN3 | 5774 | A_23_P403898 | -0.3583 | 0.5442 | |
| SRP007169 | PTPN3 | 5774 | RNAseq | -1.2427 | 0.0098 | |
| SRP008496 | PTPN3 | 5774 | RNAseq | -1.0293 | 0.0000 | |
| SRP064894 | PTPN3 | 5774 | RNAseq | -1.5488 | 0.0000 | |
| SRP133303 | PTPN3 | 5774 | RNAseq | -0.7941 | 0.0044 | |
| SRP159526 | PTPN3 | 5774 | RNAseq | -0.7476 | 0.0547 | |
| SRP193095 | PTPN3 | 5774 | RNAseq | -1.3748 | 0.0000 | |
| SRP219564 | PTPN3 | 5774 | RNAseq | -1.3658 | 0.0911 | |
| TCGA | PTPN3 | 5774 | RNAseq | -0.0912 | 0.2256 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by PTPN3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTPN3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTPN3 | 5774 | 5 | 9 | 16 | |
| GSE20123 | PTPN3 | 5774 | 5 | 8 | 17 | |
| GSE43470 | PTPN3 | 5774 | 4 | 3 | 36 | |
| GSE46452 | PTPN3 | 5774 | 6 | 13 | 40 | |
| GSE47630 | PTPN3 | 5774 | 3 | 16 | 21 | |
| GSE54993 | PTPN3 | 5774 | 3 | 3 | 64 | |
| GSE54994 | PTPN3 | 5774 | 9 | 10 | 34 | |
| GSE60625 | PTPN3 | 5774 | 0 | 0 | 11 | |
| GSE74703 | PTPN3 | 5774 | 4 | 3 | 29 | |
| GSE74704 | PTPN3 | 5774 | 2 | 6 | 12 | |
| TCGA | PTPN3 | 5774 | 25 | 21 | 50 |
Total number of gains: 66; Total number of losses: 92; Total Number of normals: 330.
Somatic mutations of PTPN3:
Generating mutation plots.
Highly correlated genes for PTPN3:
Showing top 20/1111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTPN3 | MARVELD2 | 0.80939 | 4 | 0 | 4 |
| PTPN3 | ARHGAP27 | 0.761239 | 8 | 0 | 8 |
| PTPN3 | WWC1 | 0.755284 | 12 | 0 | 12 |
| PTPN3 | MPZL3 | 0.731975 | 8 | 0 | 8 |
| PTPN3 | MARS2 | 0.730386 | 3 | 0 | 3 |
| PTPN3 | DENND2C | 0.730014 | 6 | 0 | 6 |
| PTPN3 | ZDHHC13 | 0.717657 | 12 | 0 | 11 |
| PTPN3 | COX19 | 0.715531 | 3 | 0 | 3 |
| PTPN3 | ASPG | 0.714032 | 4 | 0 | 4 |
| PTPN3 | TAB3 | 0.712401 | 6 | 0 | 6 |
| PTPN3 | PCBP1-AS1 | 0.712077 | 3 | 0 | 3 |
| PTPN3 | MXD1 | 0.711213 | 9 | 0 | 9 |
| PTPN3 | FAM214A | 0.710177 | 5 | 0 | 5 |
| PTPN3 | GCHFR | 0.709054 | 7 | 0 | 7 |
| PTPN3 | C15orf62 | 0.708093 | 7 | 0 | 6 |
| PTPN3 | EPS8L1 | 0.706755 | 11 | 0 | 11 |
| PTPN3 | VPS37B | 0.706602 | 10 | 0 | 10 |
| PTPN3 | TSPAN6 | 0.706521 | 11 | 0 | 10 |
| PTPN3 | NUAK2 | 0.7063 | 3 | 0 | 3 |
| PTPN3 | C4orf3 | 0.705225 | 5 | 0 | 5 |
For details and further investigation, click here
