MRPL3

 

Full name: mitochondrial ribosomal protein L3 Alias Symbol: MRL3
Type: protein-coding gene Cytoband: 3q22.1
Entrez ID: 11222 HGNC ID: HGNC:10379 Ensembl Gene: ENSG00000114686 OMIM ID: 607118
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MRPL3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MRPL3 11222 208787_at 0.6172 0.0400
GSE20347 MRPL3 11222 208787_at 0.6864 0.0000
GSE23400 MRPL3 11222 208787_at 1.0428 0.0000
GSE26886 MRPL3 11222 208787_at 0.1861 0.2348
GSE29001 MRPL3 11222 208787_at 0.7527 0.0014
GSE38129 MRPL3 11222 208787_at 0.8338 0.0000
GSE45670 MRPL3 11222 208787_at 0.5859 0.0009
GSE53622 MRPL3 11222 91261 0.5581 0.0000
GSE53624 MRPL3 11222 91261 0.7002 0.0000
GSE63941 MRPL3 11222 208787_at 1.1692 0.0030
GSE77861 MRPL3 11222 208787_at 0.3042 0.1949
GSE97050 MRPL3 11222 A_23_P18422 0.6437 0.0959
SRP007169 MRPL3 11222 RNAseq 0.6733 0.0495
SRP008496 MRPL3 11222 RNAseq 0.9438 0.0000
SRP064894 MRPL3 11222 RNAseq 0.4951 0.0142
SRP133303 MRPL3 11222 RNAseq 0.7576 0.0000
SRP159526 MRPL3 11222 RNAseq 0.4962 0.1384
SRP193095 MRPL3 11222 RNAseq 0.2252 0.1119
SRP219564 MRPL3 11222 RNAseq 0.4135 0.1943
TCGA MRPL3 11222 RNAseq 0.2410 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by MRPL3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MRPL3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MRPL3 11222 16 0 14
GSE20123 MRPL3 11222 16 0 14
GSE43470 MRPL3 11222 21 0 22
GSE46452 MRPL3 11222 15 4 40
GSE47630 MRPL3 11222 18 3 19
GSE54993 MRPL3 11222 2 8 60
GSE54994 MRPL3 11222 32 3 18
GSE60625 MRPL3 11222 0 6 5
GSE74703 MRPL3 11222 18 0 18
GSE74704 MRPL3 11222 12 0 8
TCGA MRPL3 11222 59 5 32

Total number of gains: 209; Total number of losses: 29; Total Number of normals: 250.  

 

Somatic mutations of MRPL3:

 

Generating mutation plots.

 

Highly correlated genes for MRPL3:

 

Showing top 20/1910 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MRPL3UMPS0.84283111011
MRPL3SPNS10.821813303
MRPL3TP53RK0.772475303
MRPL3GMPS0.76517713012
MRPL3NACC10.761685303
MRPL3ZNF2070.760089404
MRPL3PDCD60.759659303
MRPL3PIK3R40.75303112011
MRPL3TOPBP10.75289613012
MRPL3RAD180.752321303
MRPL3C12orf730.750468404
MRPL3RUVBL10.75010613012
MRPL3SYNE20.747211303
MRPL3ACTL6A0.74684713012
MRPL3SLC25A390.745795303
MRPL3PRMT10.737942909
MRPL3NOL110.73456412012
MRPL3PSMC20.73445810010
MRPL3ATP2C10.73139312012
MRPL3CCT50.729903909

For details and further investigation, click here