| Full name: activity regulated cytoskeleton associated protein | Alias Symbol: KIAA0278|Arg3.1 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 23237 | HGNC ID: HGNC:648 | Ensembl Gene: ENSG00000198576 | OMIM ID: 612461 |
| Drug and gene relationship at DGIdb | |||
ARC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05031 | Amphetamine addiction |
Expression of ARC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARC | 23237 | 210090_at | -0.1013 | 0.9134 | |
| GSE20347 | ARC | 23237 | 210090_at | -0.1583 | 0.0358 | |
| GSE23400 | ARC | 23237 | 210090_at | -0.2800 | 0.0000 | |
| GSE26886 | ARC | 23237 | 210090_at | 0.4023 | 0.0728 | |
| GSE29001 | ARC | 23237 | 210090_at | -0.1322 | 0.3642 | |
| GSE38129 | ARC | 23237 | 210090_at | -0.2971 | 0.0494 | |
| GSE45670 | ARC | 23237 | 210090_at | 0.3851 | 0.1985 | |
| GSE53622 | ARC | 23237 | 27988 | -0.6278 | 0.0297 | |
| GSE53624 | ARC | 23237 | 27988 | -0.2007 | 0.3216 | |
| GSE63941 | ARC | 23237 | 210090_at | 0.1892 | 0.6037 | |
| GSE77861 | ARC | 23237 | 210090_at | -0.0974 | 0.6651 | |
| GSE97050 | ARC | 23237 | A_23_P365738 | -0.7992 | 0.4293 | |
| SRP133303 | ARC | 23237 | RNAseq | -0.6305 | 0.2579 | |
| SRP159526 | ARC | 23237 | RNAseq | -0.8207 | 0.3589 | |
| SRP219564 | ARC | 23237 | RNAseq | -0.6680 | 0.2017 | |
| TCGA | ARC | 23237 | RNAseq | -0.4792 | 0.1331 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARC | 23237 | 16 | 1 | 13 | |
| GSE20123 | ARC | 23237 | 17 | 1 | 12 | |
| GSE43470 | ARC | 23237 | 17 | 2 | 24 | |
| GSE46452 | ARC | 23237 | 27 | 0 | 32 | |
| GSE47630 | ARC | 23237 | 23 | 1 | 16 | |
| GSE54993 | ARC | 23237 | 0 | 25 | 45 | |
| GSE54994 | ARC | 23237 | 39 | 1 | 13 | |
| GSE60625 | ARC | 23237 | 3 | 4 | 4 | |
| GSE74703 | ARC | 23237 | 15 | 1 | 20 | |
| GSE74704 | ARC | 23237 | 10 | 0 | 10 | |
| TCGA | ARC | 23237 | 63 | 2 | 31 |
Total number of gains: 230; Total number of losses: 38; Total Number of normals: 220.
Somatic mutations of ARC:
Generating mutation plots.
Highly correlated genes for ARC:
Showing top 20/274 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARC | PRPH | 0.718753 | 3 | 0 | 3 |
| ARC | LINC00598 | 0.695145 | 3 | 0 | 3 |
| ARC | HOXA11-AS | 0.684842 | 3 | 0 | 3 |
| ARC | SEMA6B | 0.681746 | 3 | 0 | 3 |
| ARC | TNFRSF4 | 0.681189 | 3 | 0 | 3 |
| ARC | ZNF683 | 0.667284 | 3 | 0 | 3 |
| ARC | REM1 | 0.663705 | 3 | 0 | 3 |
| ARC | TAF1 | 0.661864 | 3 | 0 | 3 |
| ARC | CPLX3 | 0.659171 | 4 | 0 | 3 |
| ARC | NR4A1 | 0.658703 | 6 | 0 | 5 |
| ARC | KCNE1 | 0.654255 | 4 | 0 | 4 |
| ARC | LGI4 | 0.653291 | 3 | 0 | 3 |
| ARC | TTC9B | 0.64938 | 3 | 0 | 3 |
| ARC | SFXN5 | 0.646198 | 3 | 0 | 3 |
| ARC | NFAM1 | 0.641536 | 3 | 0 | 3 |
| ARC | ZNF696 | 0.639907 | 3 | 0 | 3 |
| ARC | CCDC114 | 0.638964 | 3 | 0 | 3 |
| ARC | DGKB | 0.638943 | 4 | 0 | 3 |
| ARC | NANOS3 | 0.637367 | 3 | 0 | 3 |
| ARC | KRT81 | 0.634939 | 4 | 0 | 4 |
For details and further investigation, click here
