| Full name: nuclear receptor subfamily 4 group A member 1 | Alias Symbol: TR3|N10|NAK-1|NGFIB|NUR77 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3164 | HGNC ID: HGNC:7980 | Ensembl Gene: ENSG00000123358 | OMIM ID: 139139 |
| Drug and gene relationship at DGIdb | |||
NR4A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04925 | Aldosterone synthesis and secretion |
Expression of NR4A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NR4A1 | 3164 | 202340_x_at | -0.5558 | 0.6489 | |
| GSE20347 | NR4A1 | 3164 | 202340_x_at | 0.2814 | 0.2078 | |
| GSE23400 | NR4A1 | 3164 | 202340_x_at | -0.3861 | 0.0198 | |
| GSE26886 | NR4A1 | 3164 | 202340_x_at | 0.9143 | 0.0014 | |
| GSE29001 | NR4A1 | 3164 | 202340_x_at | -0.0389 | 0.9097 | |
| GSE38129 | NR4A1 | 3164 | 202340_x_at | -0.3639 | 0.1946 | |
| GSE45670 | NR4A1 | 3164 | 202340_x_at | -0.3366 | 0.1344 | |
| GSE63941 | NR4A1 | 3164 | 202340_x_at | -0.3034 | 0.2976 | |
| GSE77861 | NR4A1 | 3164 | 211143_x_at | 0.0633 | 0.7361 | |
| GSE97050 | NR4A1 | 3164 | A_33_P3319791 | -0.3952 | 0.7027 | |
| SRP007169 | NR4A1 | 3164 | RNAseq | 0.5848 | 0.3699 | |
| SRP008496 | NR4A1 | 3164 | RNAseq | 0.4322 | 0.3726 | |
| SRP064894 | NR4A1 | 3164 | RNAseq | -0.4646 | 0.3765 | |
| SRP133303 | NR4A1 | 3164 | RNAseq | -0.8262 | 0.0918 | |
| SRP159526 | NR4A1 | 3164 | RNAseq | 0.8320 | 0.1542 | |
| SRP193095 | NR4A1 | 3164 | RNAseq | 1.1681 | 0.0233 | |
| TCGA | NR4A1 | 3164 | RNAseq | -0.3965 | 0.0033 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NR4A1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NR4A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NR4A1 | 3164 | 8 | 2 | 20 | |
| GSE20123 | NR4A1 | 3164 | 8 | 1 | 21 | |
| GSE43470 | NR4A1 | 3164 | 4 | 0 | 39 | |
| GSE46452 | NR4A1 | 3164 | 7 | 1 | 51 | |
| GSE47630 | NR4A1 | 3164 | 10 | 2 | 28 | |
| GSE54993 | NR4A1 | 3164 | 0 | 5 | 65 | |
| GSE54994 | NR4A1 | 3164 | 3 | 2 | 48 | |
| GSE60625 | NR4A1 | 3164 | 0 | 0 | 11 | |
| GSE74703 | NR4A1 | 3164 | 3 | 0 | 33 | |
| GSE74704 | NR4A1 | 3164 | 5 | 1 | 14 | |
| TCGA | NR4A1 | 3164 | 12 | 11 | 73 |
Total number of gains: 60; Total number of losses: 25; Total Number of normals: 403.
Somatic mutations of NR4A1:
Generating mutation plots.
Highly correlated genes for NR4A1:
Showing top 20/541 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NR4A1 | C9orf47 | 0.767292 | 3 | 0 | 3 |
| NR4A1 | CNTD1 | 0.74458 | 3 | 0 | 3 |
| NR4A1 | KRT81 | 0.74397 | 4 | 0 | 3 |
| NR4A1 | DGKG | 0.740731 | 3 | 0 | 3 |
| NR4A1 | SLC11A1 | 0.733995 | 3 | 0 | 3 |
| NR4A1 | ATF3 | 0.730906 | 8 | 0 | 8 |
| NR4A1 | HES4 | 0.72059 | 3 | 0 | 3 |
| NR4A1 | PI16 | 0.714477 | 5 | 0 | 4 |
| NR4A1 | ENTPD2 | 0.712371 | 4 | 0 | 3 |
| NR4A1 | LINC00598 | 0.712166 | 3 | 0 | 3 |
| NR4A1 | EGR3 | 0.711766 | 8 | 0 | 8 |
| NR4A1 | ARMC9 | 0.710774 | 3 | 0 | 3 |
| NR4A1 | DDIT3 | 0.710703 | 4 | 0 | 3 |
| NR4A1 | RHOB | 0.7107 | 9 | 0 | 8 |
| NR4A1 | GPR3 | 0.708676 | 4 | 0 | 3 |
| NR4A1 | FGF16 | 0.706824 | 3 | 0 | 3 |
| NR4A1 | FOXC1 | 0.706401 | 3 | 0 | 3 |
| NR4A1 | C2CD4B | 0.705545 | 3 | 0 | 3 |
| NR4A1 | ABRA | 0.704754 | 3 | 0 | 3 |
| NR4A1 | C2orf88 | 0.703058 | 4 | 0 | 4 |
For details and further investigation, click here
