| Full name: peripherin | Alias Symbol: PRPH1 | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 5630 | HGNC ID: HGNC:9461 | Ensembl Gene: ENSG00000135406 | OMIM ID: 170710 |
| Drug and gene relationship at DGIdb | |||
PRPH involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
Expression of PRPH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRPH | 5630 | 213847_at | -0.1496 | 0.7467 | |
| GSE20347 | PRPH | 5630 | 213847_at | 0.0451 | 0.6616 | |
| GSE23400 | PRPH | 5630 | 213847_at | -0.0957 | 0.0098 | |
| GSE26886 | PRPH | 5630 | 213847_at | 0.6226 | 0.0637 | |
| GSE29001 | PRPH | 5630 | 213847_at | -0.0236 | 0.9237 | |
| GSE38129 | PRPH | 5630 | 213847_at | -0.1565 | 0.2044 | |
| GSE45670 | PRPH | 5630 | 213847_at | 0.0106 | 0.9334 | |
| GSE53622 | PRPH | 5630 | 26689 | 0.2317 | 0.3719 | |
| GSE53624 | PRPH | 5630 | 26689 | 1.0063 | 0.0000 | |
| GSE63941 | PRPH | 5630 | 213847_at | 0.8706 | 0.0218 | |
| GSE77861 | PRPH | 5630 | 213847_at | -0.1457 | 0.2009 | |
| GSE97050 | PRPH | 5630 | A_23_P13713 | -0.0589 | 0.8779 | |
| SRP159526 | PRPH | 5630 | RNAseq | 1.2103 | 0.0393 | |
| SRP219564 | PRPH | 5630 | RNAseq | -0.9320 | 0.2464 | |
| TCGA | PRPH | 5630 | RNAseq | -1.2216 | 0.0119 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by PRPH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRPH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRPH | 5630 | 6 | 1 | 23 | |
| GSE20123 | PRPH | 5630 | 7 | 1 | 22 | |
| GSE43470 | PRPH | 5630 | 3 | 1 | 39 | |
| GSE46452 | PRPH | 5630 | 8 | 1 | 50 | |
| GSE47630 | PRPH | 5630 | 11 | 2 | 27 | |
| GSE54993 | PRPH | 5630 | 0 | 5 | 65 | |
| GSE54994 | PRPH | 5630 | 4 | 1 | 48 | |
| GSE60625 | PRPH | 5630 | 0 | 0 | 11 | |
| GSE74703 | PRPH | 5630 | 3 | 1 | 32 | |
| GSE74704 | PRPH | 5630 | 5 | 1 | 14 | |
| TCGA | PRPH | 5630 | 16 | 11 | 69 |
Total number of gains: 63; Total number of losses: 25; Total Number of normals: 400.
Somatic mutations of PRPH:
Generating mutation plots.
Highly correlated genes for PRPH:
Showing top 20/689 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRPH | IQUB | 0.719693 | 3 | 0 | 3 |
| PRPH | ARC | 0.718753 | 3 | 0 | 3 |
| PRPH | ARHGEF17 | 0.703064 | 4 | 0 | 4 |
| PRPH | FZR1 | 0.702439 | 4 | 0 | 4 |
| PRPH | ANKRD34C | 0.701914 | 3 | 0 | 3 |
| PRPH | SSC5D | 0.701527 | 3 | 0 | 3 |
| PRPH | RNF185-AS1 | 0.700306 | 3 | 0 | 3 |
| PRPH | ENTPD2 | 0.699593 | 4 | 0 | 3 |
| PRPH | NCAM1 | 0.699507 | 4 | 0 | 4 |
| PRPH | PI16 | 0.698516 | 3 | 0 | 3 |
| PRPH | NPTX1 | 0.695023 | 5 | 0 | 5 |
| PRPH | C2orf83 | 0.682467 | 3 | 0 | 3 |
| PRPH | PPP5C | 0.675134 | 6 | 0 | 6 |
| PRPH | UBE2D4 | 0.669818 | 7 | 0 | 6 |
| PRPH | SORCS1 | 0.664349 | 3 | 0 | 3 |
| PRPH | CCDC136 | 0.663039 | 4 | 0 | 3 |
| PRPH | NEUROD4 | 0.658141 | 7 | 0 | 6 |
| PRPH | CCR10 | 0.65574 | 5 | 0 | 4 |
| PRPH | CNTN2 | 0.655618 | 5 | 0 | 4 |
| PRPH | FLRT1 | 0.652962 | 6 | 0 | 6 |
For details and further investigation, click here
