| Full name: ADP ribosylation factor guanine nucleotide exchange factor 2 | Alias Symbol: BIG2 | ||
| Type: protein-coding gene | Cytoband: 20q13.13 | ||
| Entrez ID: 10564 | HGNC ID: HGNC:15853 | Ensembl Gene: ENSG00000124198 | OMIM ID: 605371 |
| Drug and gene relationship at DGIdb | |||
Expression of ARFGEF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARFGEF2 | 10564 | 218098_at | 0.4113 | 0.4165 | |
| GSE20347 | ARFGEF2 | 10564 | 218098_at | -0.4227 | 0.0034 | |
| GSE23400 | ARFGEF2 | 10564 | 218098_at | -0.0557 | 0.5366 | |
| GSE26886 | ARFGEF2 | 10564 | 218098_at | -0.7969 | 0.0135 | |
| GSE29001 | ARFGEF2 | 10564 | 218098_at | -0.0057 | 0.9898 | |
| GSE38129 | ARFGEF2 | 10564 | 218098_at | -0.2421 | 0.0805 | |
| GSE45670 | ARFGEF2 | 10564 | 218098_at | -0.0869 | 0.6050 | |
| GSE53622 | ARFGEF2 | 10564 | 105382 | -0.0752 | 0.2977 | |
| GSE53624 | ARFGEF2 | 10564 | 105382 | -0.3941 | 0.0000 | |
| GSE63941 | ARFGEF2 | 10564 | 218098_at | -0.5329 | 0.2466 | |
| GSE77861 | ARFGEF2 | 10564 | 218098_at | -0.4651 | 0.0607 | |
| GSE97050 | ARFGEF2 | 10564 | A_33_P3271925 | -0.0626 | 0.8164 | |
| SRP007169 | ARFGEF2 | 10564 | RNAseq | -0.6462 | 0.0640 | |
| SRP008496 | ARFGEF2 | 10564 | RNAseq | -0.5919 | 0.0037 | |
| SRP064894 | ARFGEF2 | 10564 | RNAseq | -0.2273 | 0.4540 | |
| SRP133303 | ARFGEF2 | 10564 | RNAseq | -0.0235 | 0.7743 | |
| SRP159526 | ARFGEF2 | 10564 | RNAseq | -0.1845 | 0.5717 | |
| SRP193095 | ARFGEF2 | 10564 | RNAseq | -0.2951 | 0.0005 | |
| SRP219564 | ARFGEF2 | 10564 | RNAseq | -0.1160 | 0.7677 | |
| TCGA | ARFGEF2 | 10564 | RNAseq | -0.1950 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ARFGEF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARFGEF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARFGEF2 | 10564 | 16 | 2 | 12 | |
| GSE20123 | ARFGEF2 | 10564 | 16 | 2 | 12 | |
| GSE43470 | ARFGEF2 | 10564 | 12 | 0 | 31 | |
| GSE46452 | ARFGEF2 | 10564 | 29 | 0 | 30 | |
| GSE47630 | ARFGEF2 | 10564 | 24 | 1 | 15 | |
| GSE54993 | ARFGEF2 | 10564 | 0 | 18 | 52 | |
| GSE54994 | ARFGEF2 | 10564 | 26 | 0 | 27 | |
| GSE60625 | ARFGEF2 | 10564 | 0 | 0 | 11 | |
| GSE74703 | ARFGEF2 | 10564 | 10 | 0 | 26 | |
| GSE74704 | ARFGEF2 | 10564 | 12 | 0 | 8 | |
| TCGA | ARFGEF2 | 10564 | 46 | 3 | 47 |
Total number of gains: 191; Total number of losses: 26; Total Number of normals: 271.
Somatic mutations of ARFGEF2:
Generating mutation plots.
Highly correlated genes for ARFGEF2:
Showing top 20/891 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARFGEF2 | SNX30 | 0.825998 | 3 | 0 | 3 |
| ARFGEF2 | NAA30 | 0.807149 | 3 | 0 | 3 |
| ARFGEF2 | SAMM50 | 0.776249 | 3 | 0 | 3 |
| ARFGEF2 | UBA6 | 0.773341 | 3 | 0 | 3 |
| ARFGEF2 | MRTO4 | 0.773338 | 3 | 0 | 3 |
| ARFGEF2 | SEC22A | 0.772128 | 3 | 0 | 3 |
| ARFGEF2 | RNF14 | 0.768153 | 3 | 0 | 3 |
| ARFGEF2 | JAK1 | 0.765381 | 3 | 0 | 3 |
| ARFGEF2 | NCKAP1 | 0.764894 | 4 | 0 | 4 |
| ARFGEF2 | MRPS15 | 0.758986 | 3 | 0 | 3 |
| ARFGEF2 | NAA25 | 0.75789 | 3 | 0 | 3 |
| ARFGEF2 | CDC73 | 0.752351 | 3 | 0 | 3 |
| ARFGEF2 | SLC25A30 | 0.750797 | 3 | 0 | 3 |
| ARFGEF2 | C1D | 0.7492 | 3 | 0 | 3 |
| ARFGEF2 | DHX8 | 0.747674 | 3 | 0 | 3 |
| ARFGEF2 | ZBTB34 | 0.747467 | 3 | 0 | 3 |
| ARFGEF2 | PITRM1 | 0.746246 | 3 | 0 | 3 |
| ARFGEF2 | FBXL3 | 0.745253 | 3 | 0 | 3 |
| ARFGEF2 | HSPA9 | 0.740937 | 3 | 0 | 3 |
| ARFGEF2 | NUP54 | 0.737991 | 4 | 0 | 3 |
For details and further investigation, click here
