JAK1

 

Full name: Janus kinase 1 Alias Symbol: JAK1A|JTK3
Type: protein-coding gene Cytoband: 1p31.3
Entrez ID: 3716 HGNC ID: HGNC:6190 Ensembl Gene: ENSG00000162434 OMIM ID: 147795
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 4/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

JAK1 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04380Osteoclast differentiation
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04630Jak-STAT signaling pathway
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05212Pancreatic cancer

 

Expression of JAK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 JAK1 3716 201648_at 0.0306 0.9479
GSE20347 JAK1 3716 201648_at -0.1887 0.2610
GSE23400 JAK1 3716 201648_at 0.0922 0.2158
GSE26886 JAK1 3716 201648_at -0.5358 0.0397
GSE29001 JAK1 3716 201648_at -0.0939 0.7840
GSE38129 JAK1 3716 201648_at -0.2593 0.1077
GSE45670 JAK1 3716 201648_at -0.0414 0.8127
GSE53622 JAK1 3716 11124 0.1433 0.0192
GSE53624 JAK1 3716 11124 -0.0649 0.4147
GSE63941 JAK1 3716 201648_at -1.6461 0.0194
GSE77861 JAK1 3716 201648_at -0.1964 0.6553
GSE97050 JAK1 3716 A_33_P3784283 0.3965 0.1834
SRP007169 JAK1 3716 RNAseq -0.1075 0.7820
SRP008496 JAK1 3716 RNAseq -0.0100 0.9606
SRP064894 JAK1 3716 RNAseq 0.1800 0.2927
SRP133303 JAK1 3716 RNAseq 0.2237 0.1649
SRP159526 JAK1 3716 RNAseq -0.5621 0.0136
SRP193095 JAK1 3716 RNAseq -0.0274 0.8118
SRP219564 JAK1 3716 RNAseq 0.1837 0.4163
TCGA JAK1 3716 RNAseq -0.1112 0.0068

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by JAK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of JAK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 JAK1 3716 3 6 21
GSE20123 JAK1 3716 3 5 22
GSE43470 JAK1 3716 4 4 35
GSE46452 JAK1 3716 0 1 58
GSE47630 JAK1 3716 8 5 27
GSE54993 JAK1 3716 0 0 70
GSE54994 JAK1 3716 6 4 43
GSE60625 JAK1 3716 0 0 11
GSE74703 JAK1 3716 3 3 30
GSE74704 JAK1 3716 2 2 16
TCGA JAK1 3716 10 20 66

Total number of gains: 39; Total number of losses: 50; Total Number of normals: 399.  

 

Somatic mutations of JAK1:

 

Generating mutation plots.

 

Highly correlated genes for JAK1:

 

Showing top 20/591 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
JAK1TRAPPC6B0.779097303
JAK1ARFGEF20.765381303
JAK1CASC40.759792303
JAK1RPS230.753569303
JAK1SCRN10.749716303
JAK1MGAT20.746703303
JAK1KLHL90.725416303
JAK1SGMS20.724739303
JAK1NAA300.72151303
JAK1PSMD80.713764303
JAK1ARL6IP60.711636303
JAK1RBM120.706808303
JAK1NIPAL30.701396303
JAK1CHMP2A0.700607303
JAK1FAM151B0.699101303
JAK1PPM1A0.696052605
JAK1NUDCD30.695313303
JAK1ATG2B0.694766404
JAK1STT3B0.690718404
JAK1AP3M10.687714303

For details and further investigation, click here