| Full name: SHANK associated RH domain interactor | Alias Symbol: DKFZP434N1923|SIPL1 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 81858 | HGNC ID: HGNC:25321 | Ensembl Gene: ENSG00000179526 | OMIM ID: 611885 |
| Drug and gene relationship at DGIdb | |||
Expression of SHARPIN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHARPIN | 81858 | 220973_s_at | 0.4477 | 0.3529 | |
| GSE20347 | SHARPIN | 81858 | 220973_s_at | 0.1617 | 0.0655 | |
| GSE23400 | SHARPIN | 81858 | 220973_s_at | 0.2038 | 0.0029 | |
| GSE26886 | SHARPIN | 81858 | 220973_s_at | 0.9164 | 0.0000 | |
| GSE29001 | SHARPIN | 81858 | 220973_s_at | 0.0122 | 0.9669 | |
| GSE38129 | SHARPIN | 81858 | 220973_s_at | 0.0453 | 0.6080 | |
| GSE45670 | SHARPIN | 81858 | 220973_s_at | 0.2480 | 0.0044 | |
| GSE53622 | SHARPIN | 81858 | 25522 | 0.1581 | 0.0066 | |
| GSE53624 | SHARPIN | 81858 | 25522 | 0.3417 | 0.0000 | |
| GSE63941 | SHARPIN | 81858 | 220973_s_at | 0.2942 | 0.4205 | |
| GSE77861 | SHARPIN | 81858 | 220973_s_at | 0.0985 | 0.6550 | |
| GSE97050 | SHARPIN | 81858 | A_33_P3213551 | 0.1221 | 0.6011 | |
| SRP007169 | SHARPIN | 81858 | RNAseq | -1.4483 | 0.0001 | |
| SRP008496 | SHARPIN | 81858 | RNAseq | -0.8870 | 0.0024 | |
| SRP064894 | SHARPIN | 81858 | RNAseq | 0.9750 | 0.0041 | |
| SRP133303 | SHARPIN | 81858 | RNAseq | 0.2574 | 0.1324 | |
| SRP159526 | SHARPIN | 81858 | RNAseq | 0.0216 | 0.9151 | |
| SRP193095 | SHARPIN | 81858 | RNAseq | 0.3051 | 0.0172 | |
| SRP219564 | SHARPIN | 81858 | RNAseq | 0.4885 | 0.3210 | |
| TCGA | SHARPIN | 81858 | RNAseq | 0.0657 | 0.2254 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SHARPIN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHARPIN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHARPIN | 81858 | 17 | 1 | 12 | |
| GSE20123 | SHARPIN | 81858 | 17 | 1 | 12 | |
| GSE43470 | SHARPIN | 81858 | 16 | 2 | 25 | |
| GSE46452 | SHARPIN | 81858 | 27 | 0 | 32 | |
| GSE47630 | SHARPIN | 81858 | 23 | 1 | 16 | |
| GSE54993 | SHARPIN | 81858 | 0 | 25 | 45 | |
| GSE54994 | SHARPIN | 81858 | 39 | 1 | 13 | |
| GSE60625 | SHARPIN | 81858 | 3 | 4 | 4 | |
| GSE74703 | SHARPIN | 81858 | 14 | 1 | 21 | |
| GSE74704 | SHARPIN | 81858 | 10 | 0 | 10 | |
| TCGA | SHARPIN | 81858 | 63 | 2 | 31 |
Total number of gains: 229; Total number of losses: 38; Total Number of normals: 221.
Somatic mutations of SHARPIN:
Generating mutation plots.
Highly correlated genes for SHARPIN:
Showing top 20/488 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHARPIN | FBRSL1 | 0.910967 | 3 | 0 | 3 |
| SHARPIN | TFE3 | 0.8448 | 3 | 0 | 3 |
| SHARPIN | CPAMD8 | 0.820157 | 4 | 0 | 4 |
| SHARPIN | PGP | 0.76741 | 3 | 0 | 3 |
| SHARPIN | HSD17B14 | 0.765431 | 4 | 0 | 4 |
| SHARPIN | FASTK | 0.762617 | 3 | 0 | 3 |
| SHARPIN | STK32C | 0.749367 | 5 | 0 | 4 |
| SHARPIN | C4orf47 | 0.748168 | 3 | 0 | 3 |
| SHARPIN | PPP1R12C | 0.747309 | 3 | 0 | 3 |
| SHARPIN | ARHGAP21 | 0.746898 | 3 | 0 | 3 |
| SHARPIN | C20orf141 | 0.742795 | 3 | 0 | 3 |
| SHARPIN | CHGB | 0.740108 | 3 | 0 | 3 |
| SHARPIN | GYPE | 0.732361 | 4 | 0 | 4 |
| SHARPIN | CDH2 | 0.729191 | 4 | 0 | 4 |
| SHARPIN | C19orf44 | 0.723302 | 3 | 0 | 3 |
| SHARPIN | UPB1 | 0.713623 | 3 | 0 | 3 |
| SHARPIN | PLEKHG4 | 0.713427 | 3 | 0 | 3 |
| SHARPIN | HSD3B1 | 0.712593 | 3 | 0 | 3 |
| SHARPIN | FAM83E | 0.7075 | 3 | 0 | 3 |
| SHARPIN | IGFALS | 0.707083 | 4 | 0 | 4 |
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