| Full name: laminin subunit alpha 3 | Alias Symbol: nicein-150kDa|kalinin-165kDa|BM600-150kDa|epiligrin | ||
| Type: protein-coding gene | Cytoband: 18q11.2 | ||
| Entrez ID: 3909 | HGNC ID: HGNC:6483 | Ensembl Gene: ENSG00000053747 | OMIM ID: 600805 |
| Drug and gene relationship at DGIdb | |||
LAMA3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of LAMA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAMA3 | 3909 | 203726_s_at | 1.1667 | 0.2415 | |
| GSE20347 | LAMA3 | 3909 | 203726_s_at | 1.2932 | 0.0001 | |
| GSE23400 | LAMA3 | 3909 | 203726_s_at | 1.6933 | 0.0000 | |
| GSE26886 | LAMA3 | 3909 | 203726_s_at | 2.4221 | 0.0000 | |
| GSE29001 | LAMA3 | 3909 | 203726_s_at | 1.5143 | 0.0034 | |
| GSE38129 | LAMA3 | 3909 | 203726_s_at | 1.5611 | 0.0000 | |
| GSE45670 | LAMA3 | 3909 | 203726_s_at | 1.5466 | 0.0053 | |
| GSE53622 | LAMA3 | 3909 | 40950 | 1.7677 | 0.0000 | |
| GSE53624 | LAMA3 | 3909 | 40950 | 1.7292 | 0.0000 | |
| GSE63941 | LAMA3 | 3909 | 203726_s_at | 1.4990 | 0.0941 | |
| GSE77861 | LAMA3 | 3909 | 203726_s_at | 1.6090 | 0.0361 | |
| GSE97050 | LAMA3 | 3909 | A_33_P3262560 | -0.0632 | 0.7903 | |
| SRP007169 | LAMA3 | 3909 | RNAseq | 3.7132 | 0.0000 | |
| SRP008496 | LAMA3 | 3909 | RNAseq | 3.4694 | 0.0000 | |
| SRP064894 | LAMA3 | 3909 | RNAseq | 2.4284 | 0.0000 | |
| SRP133303 | LAMA3 | 3909 | RNAseq | 2.1607 | 0.0000 | |
| SRP159526 | LAMA3 | 3909 | RNAseq | 1.1840 | 0.0437 | |
| SRP193095 | LAMA3 | 3909 | RNAseq | 1.4828 | 0.0000 | |
| SRP219564 | LAMA3 | 3909 | RNAseq | 2.7824 | 0.0012 | |
| TCGA | LAMA3 | 3909 | RNAseq | 0.3393 | 0.0088 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by LAMA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAMA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAMA3 | 3909 | 2 | 5 | 23 | |
| GSE20123 | LAMA3 | 3909 | 1 | 5 | 24 | |
| GSE43470 | LAMA3 | 3909 | 2 | 1 | 40 | |
| GSE46452 | LAMA3 | 3909 | 4 | 23 | 32 | |
| GSE47630 | LAMA3 | 3909 | 7 | 18 | 15 | |
| GSE54993 | LAMA3 | 3909 | 7 | 1 | 62 | |
| GSE54994 | LAMA3 | 3909 | 4 | 12 | 37 | |
| GSE60625 | LAMA3 | 3909 | 0 | 4 | 7 | |
| GSE74703 | LAMA3 | 3909 | 2 | 1 | 33 | |
| GSE74704 | LAMA3 | 3909 | 1 | 4 | 15 | |
| TCGA | LAMA3 | 3909 | 16 | 26 | 54 |
Total number of gains: 46; Total number of losses: 100; Total Number of normals: 342.
Somatic mutations of LAMA3:
Generating mutation plots.
Highly correlated genes for LAMA3:
Showing top 20/490 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAMA3 | LAMC2 | 0.832638 | 12 | 0 | 12 |
| LAMA3 | SNAI2 | 0.805666 | 10 | 0 | 10 |
| LAMA3 | LAMB3 | 0.780042 | 12 | 0 | 11 |
| LAMA3 | DPM3 | 0.774681 | 3 | 0 | 3 |
| LAMA3 | TANK | 0.747673 | 3 | 0 | 3 |
| LAMA3 | PTHLH | 0.735274 | 11 | 0 | 10 |
| LAMA3 | CDH3 | 0.733432 | 10 | 0 | 10 |
| LAMA3 | CTHRC1 | 0.726828 | 6 | 0 | 6 |
| LAMA3 | MYO10 | 0.722 | 9 | 0 | 9 |
| LAMA3 | C1QTNF6 | 0.717669 | 7 | 0 | 6 |
| LAMA3 | CPAMD8 | 0.715881 | 3 | 0 | 3 |
| LAMA3 | CHST10 | 0.713883 | 3 | 0 | 3 |
| LAMA3 | NPW | 0.713008 | 4 | 0 | 4 |
| LAMA3 | MMP1 | 0.70855 | 11 | 0 | 10 |
| LAMA3 | FSCN1 | 0.707172 | 12 | 0 | 10 |
| LAMA3 | COL7A1 | 0.701923 | 11 | 0 | 10 |
| LAMA3 | GRAP | 0.701751 | 3 | 0 | 3 |
| LAMA3 | VAV2 | 0.696791 | 10 | 0 | 8 |
| LAMA3 | SPATA2L | 0.696576 | 3 | 0 | 3 |
| LAMA3 | ZMYND15 | 0.694005 | 4 | 0 | 4 |
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