| Full name: leucine rich repeat kinase 1 | Alias Symbol: FLJ23119|KIAA1790|Roco1|RIPK6 | ||
| Type: protein-coding gene | Cytoband: 15q26.3 | ||
| Entrez ID: 79705 | HGNC ID: HGNC:18608 | Ensembl Gene: ENSG00000154237 | OMIM ID: 610986 |
Expression of LRRK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRK1 | 79705 | 219441_s_at | 0.0767 | 0.8690 | |
| GSE20347 | LRRK1 | 79705 | 219441_s_at | 0.1306 | 0.2592 | |
| GSE23400 | LRRK1 | 79705 | 219441_s_at | 0.0931 | 0.0051 | |
| GSE26886 | LRRK1 | 79705 | 219441_s_at | 1.0473 | 0.0000 | |
| GSE29001 | LRRK1 | 79705 | 219441_s_at | 0.0713 | 0.5785 | |
| GSE38129 | LRRK1 | 79705 | 219441_s_at | 0.0400 | 0.6913 | |
| GSE45670 | LRRK1 | 79705 | 219441_s_at | 0.0897 | 0.4961 | |
| GSE63941 | LRRK1 | 79705 | 219441_s_at | -0.9606 | 0.0780 | |
| GSE77861 | LRRK1 | 79705 | 219441_s_at | 0.0428 | 0.8342 | |
| GSE97050 | LRRK1 | 79705 | A_23_P99942 | 0.3508 | 0.2593 | |
| SRP007169 | LRRK1 | 79705 | RNAseq | 1.1950 | 0.0066 | |
| SRP008496 | LRRK1 | 79705 | RNAseq | 0.8345 | 0.0471 | |
| SRP064894 | LRRK1 | 79705 | RNAseq | 0.5461 | 0.1727 | |
| SRP133303 | LRRK1 | 79705 | RNAseq | 0.1969 | 0.2972 | |
| SRP159526 | LRRK1 | 79705 | RNAseq | 0.2090 | 0.6414 | |
| SRP193095 | LRRK1 | 79705 | RNAseq | 0.3843 | 0.0520 | |
| SRP219564 | LRRK1 | 79705 | RNAseq | 0.6129 | 0.4055 | |
| TCGA | LRRK1 | 79705 | RNAseq | 0.0769 | 0.2182 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LRRK1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LRRK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRK1 | 79705 | 7 | 2 | 21 | |
| GSE20123 | LRRK1 | 79705 | 7 | 2 | 21 | |
| GSE43470 | LRRK1 | 79705 | 6 | 5 | 32 | |
| GSE46452 | LRRK1 | 79705 | 3 | 7 | 49 | |
| GSE47630 | LRRK1 | 79705 | 9 | 10 | 21 | |
| GSE54993 | LRRK1 | 79705 | 4 | 7 | 59 | |
| GSE54994 | LRRK1 | 79705 | 8 | 7 | 38 | |
| GSE60625 | LRRK1 | 79705 | 4 | 0 | 7 | |
| GSE74703 | LRRK1 | 79705 | 5 | 4 | 27 | |
| GSE74704 | LRRK1 | 79705 | 3 | 3 | 14 | |
| TCGA | LRRK1 | 79705 | 18 | 12 | 66 |
Total number of gains: 74; Total number of losses: 59; Total Number of normals: 355.
Somatic mutations of LRRK1:
Generating mutation plots.
Highly correlated genes for LRRK1:
Showing top 20/290 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRK1 | UCP2 | 0.807782 | 3 | 0 | 3 |
| LRRK1 | PAIP1 | 0.78966 | 3 | 0 | 3 |
| LRRK1 | USP42 | 0.780558 | 3 | 0 | 3 |
| LRRK1 | MRPS26 | 0.775287 | 3 | 0 | 3 |
| LRRK1 | TTYH2 | 0.76908 | 3 | 0 | 3 |
| LRRK1 | SLC40A1 | 0.767394 | 3 | 0 | 3 |
| LRRK1 | C12orf75 | 0.764573 | 3 | 0 | 3 |
| LRRK1 | EFEMP2 | 0.748658 | 3 | 0 | 3 |
| LRRK1 | LRP12 | 0.745931 | 3 | 0 | 3 |
| LRRK1 | TSPAN9 | 0.740203 | 3 | 0 | 3 |
| LRRK1 | C1orf216 | 0.735936 | 3 | 0 | 3 |
| LRRK1 | MSTO1 | 0.734752 | 3 | 0 | 3 |
| LRRK1 | PIK3AP1 | 0.731533 | 3 | 0 | 3 |
| LRRK1 | ITGAM | 0.730814 | 3 | 0 | 3 |
| LRRK1 | SEL1L3 | 0.730722 | 3 | 0 | 3 |
| LRRK1 | ZBTB39 | 0.728913 | 3 | 0 | 3 |
| LRRK1 | MICAL1 | 0.728045 | 3 | 0 | 3 |
| LRRK1 | ZNF32 | 0.727338 | 3 | 0 | 3 |
| LRRK1 | RUNX3 | 0.727127 | 3 | 0 | 3 |
| LRRK1 | PIP4K2B | 0.726915 | 3 | 0 | 3 |
For details and further investigation, click here
