ARHGEF5

 

Full name: Rho guanine nucleotide exchange factor 5 Alias Symbol: TIM|TIM1|GEF5|P60
Type: protein-coding gene Cytoband: 7q35
Entrez ID: 7984 HGNC ID: HGNC:13209 Ensembl Gene: ENSG00000050327 OMIM ID: 600888
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ARHGEF5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ARHGEF5 7984 204765_at 0.1376 0.8649
GSE20347 ARHGEF5 7984 204765_at -0.1825 0.0992
GSE23400 ARHGEF5 7984 204765_at -0.0246 0.8334
GSE26886 ARHGEF5 7984 204765_at -0.3739 0.0698
GSE29001 ARHGEF5 7984 204765_at -0.2313 0.3426
GSE38129 ARHGEF5 7984 204765_at 0.2258 0.2923
GSE45670 ARHGEF5 7984 204765_at 0.0492 0.8001
GSE53622 ARHGEF5 7984 14807 -0.2149 0.2296
GSE53624 ARHGEF5 7984 14807 -0.4539 0.0011
GSE63941 ARHGEF5 7984 204765_at 1.3429 0.0010
GSE77861 ARHGEF5 7984 204765_at 0.0950 0.6321
GSE97050 ARHGEF5 7984 A_23_P93988 0.2410 0.5161
SRP007169 ARHGEF5 7984 RNAseq -0.6578 0.0747
SRP008496 ARHGEF5 7984 RNAseq -0.5953 0.0131
SRP064894 ARHGEF5 7984 RNAseq -0.5026 0.0962
SRP133303 ARHGEF5 7984 RNAseq -0.2659 0.3549
SRP159526 ARHGEF5 7984 RNAseq -0.0008 0.9990
SRP193095 ARHGEF5 7984 RNAseq -0.0414 0.8419
SRP219564 ARHGEF5 7984 RNAseq -0.6792 0.3145
TCGA ARHGEF5 7984 RNAseq 0.2354 0.0107

Upregulated datasets: 1; Downregulated datasets: 0.  


 

Survival by ARHGEF5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of ARHGEF5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ARHGEF5 7984 3 2 25
GSE20123 ARHGEF5 7984 3 2 25
GSE43470 ARHGEF5 7984 3 5 35
GSE46452 ARHGEF5 7984 7 2 50
GSE47630 ARHGEF5 7984 6 8 26
GSE54993 ARHGEF5 7984 3 4 63
GSE54994 ARHGEF5 7984 5 8 40
GSE60625 ARHGEF5 7984 0 0 11
GSE74703 ARHGEF5 7984 2 5 29
GSE74704 ARHGEF5 7984 1 2 17
TCGA ARHGEF5 7984 27 26 43

Total number of gains: 60; Total number of losses: 64; Total Number of normals: 364.  


 

Somatic mutations of ARHGEF5:

 

Generating mutation plots.

 

Highly correlated genes for ARHGEF5:

 

Showing top 20/606 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ARHGEF5FBXO110.797011303
ARHGEF5AAGAB0.735612404
ARHGEF5FOPNL0.732969404
ARHGEF5RTN4IP10.729822303
ARHGEF5PKP20.718005403
ARHGEF5UNC13D0.715497303
ARHGEF5YWHAE0.706255403
ARHGEF5TMEM170A0.705353303
ARHGEF5MRPL300.69831303
ARHGEF5COPE0.698216403
ARHGEF5MTCH20.697584303
ARHGEF5KIAA15220.688672504
ARHGEF5HUS10.687976403
ARHGEF5MREG0.687834805
ARHGEF5FAM110A0.687823505
ARHGEF5ERI20.685583403
ARHGEF5DIP2B0.6855605
ARHGEF5TRMT2B0.685018404
ARHGEF5DERA0.683288403
ARHGEF5PPP4C0.682563706

For details and further investigation, click here