| Full name: Rho guanine nucleotide exchange factor 5 | Alias Symbol: TIM|TIM1|GEF5|P60 | ||
| Type: protein-coding gene | Cytoband: 7q35 | ||
| Entrez ID: 7984 | HGNC ID: HGNC:13209 | Ensembl Gene: ENSG00000050327 | OMIM ID: 600888 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ARHGEF5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF5 | 7984 | 204765_at | 0.1376 | 0.8649 | |
| GSE20347 | ARHGEF5 | 7984 | 204765_at | -0.1825 | 0.0992 | |
| GSE23400 | ARHGEF5 | 7984 | 204765_at | -0.0246 | 0.8334 | |
| GSE26886 | ARHGEF5 | 7984 | 204765_at | -0.3739 | 0.0698 | |
| GSE29001 | ARHGEF5 | 7984 | 204765_at | -0.2313 | 0.3426 | |
| GSE38129 | ARHGEF5 | 7984 | 204765_at | 0.2258 | 0.2923 | |
| GSE45670 | ARHGEF5 | 7984 | 204765_at | 0.0492 | 0.8001 | |
| GSE53622 | ARHGEF5 | 7984 | 14807 | -0.2149 | 0.2296 | |
| GSE53624 | ARHGEF5 | 7984 | 14807 | -0.4539 | 0.0011 | |
| GSE63941 | ARHGEF5 | 7984 | 204765_at | 1.3429 | 0.0010 | |
| GSE77861 | ARHGEF5 | 7984 | 204765_at | 0.0950 | 0.6321 | |
| GSE97050 | ARHGEF5 | 7984 | A_23_P93988 | 0.2410 | 0.5161 | |
| SRP007169 | ARHGEF5 | 7984 | RNAseq | -0.6578 | 0.0747 | |
| SRP008496 | ARHGEF5 | 7984 | RNAseq | -0.5953 | 0.0131 | |
| SRP064894 | ARHGEF5 | 7984 | RNAseq | -0.5026 | 0.0962 | |
| SRP133303 | ARHGEF5 | 7984 | RNAseq | -0.2659 | 0.3549 | |
| SRP159526 | ARHGEF5 | 7984 | RNAseq | -0.0008 | 0.9990 | |
| SRP193095 | ARHGEF5 | 7984 | RNAseq | -0.0414 | 0.8419 | |
| SRP219564 | ARHGEF5 | 7984 | RNAseq | -0.6792 | 0.3145 | |
| TCGA | ARHGEF5 | 7984 | RNAseq | 0.2354 | 0.0107 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ARHGEF5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF5 | 7984 | 3 | 2 | 25 | |
| GSE20123 | ARHGEF5 | 7984 | 3 | 2 | 25 | |
| GSE43470 | ARHGEF5 | 7984 | 3 | 5 | 35 | |
| GSE46452 | ARHGEF5 | 7984 | 7 | 2 | 50 | |
| GSE47630 | ARHGEF5 | 7984 | 6 | 8 | 26 | |
| GSE54993 | ARHGEF5 | 7984 | 3 | 4 | 63 | |
| GSE54994 | ARHGEF5 | 7984 | 5 | 8 | 40 | |
| GSE60625 | ARHGEF5 | 7984 | 0 | 0 | 11 | |
| GSE74703 | ARHGEF5 | 7984 | 2 | 5 | 29 | |
| GSE74704 | ARHGEF5 | 7984 | 1 | 2 | 17 | |
| TCGA | ARHGEF5 | 7984 | 27 | 26 | 43 |
Total number of gains: 60; Total number of losses: 64; Total Number of normals: 364.
Somatic mutations of ARHGEF5:
Generating mutation plots.
Highly correlated genes for ARHGEF5:
Showing top 20/606 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF5 | FBXO11 | 0.797011 | 3 | 0 | 3 |
| ARHGEF5 | AAGAB | 0.735612 | 4 | 0 | 4 |
| ARHGEF5 | FOPNL | 0.732969 | 4 | 0 | 4 |
| ARHGEF5 | RTN4IP1 | 0.729822 | 3 | 0 | 3 |
| ARHGEF5 | PKP2 | 0.718005 | 4 | 0 | 3 |
| ARHGEF5 | UNC13D | 0.715497 | 3 | 0 | 3 |
| ARHGEF5 | YWHAE | 0.706255 | 4 | 0 | 3 |
| ARHGEF5 | TMEM170A | 0.705353 | 3 | 0 | 3 |
| ARHGEF5 | MRPL30 | 0.69831 | 3 | 0 | 3 |
| ARHGEF5 | COPE | 0.698216 | 4 | 0 | 3 |
| ARHGEF5 | MTCH2 | 0.697584 | 3 | 0 | 3 |
| ARHGEF5 | KIAA1522 | 0.688672 | 5 | 0 | 4 |
| ARHGEF5 | HUS1 | 0.687976 | 4 | 0 | 3 |
| ARHGEF5 | MREG | 0.687834 | 8 | 0 | 5 |
| ARHGEF5 | FAM110A | 0.687823 | 5 | 0 | 5 |
| ARHGEF5 | ERI2 | 0.685583 | 4 | 0 | 3 |
| ARHGEF5 | DIP2B | 0.6855 | 6 | 0 | 5 |
| ARHGEF5 | TRMT2B | 0.685018 | 4 | 0 | 4 |
| ARHGEF5 | DERA | 0.683288 | 4 | 0 | 3 |
| ARHGEF5 | PPP4C | 0.682563 | 7 | 0 | 6 |
For details and further investigation, click here
