| Full name: plakophilin 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p11.21 | ||
| Entrez ID: 5318 | HGNC ID: HGNC:9024 | Ensembl Gene: ENSG00000057294 | OMIM ID: 602861 |
| Drug and gene relationship at DGIdb | |||
Expression of PKP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKP2 | 5318 | 207717_s_at | -0.0018 | 0.9991 | |
| GSE20347 | PKP2 | 5318 | 207717_s_at | 0.4300 | 0.1726 | |
| GSE23400 | PKP2 | 5318 | 214154_s_at | 0.0171 | 0.6277 | |
| GSE26886 | PKP2 | 5318 | 207717_s_at | 1.0268 | 0.1106 | |
| GSE29001 | PKP2 | 5318 | 207717_s_at | 0.4501 | 0.5347 | |
| GSE38129 | PKP2 | 5318 | 207717_s_at | 0.7381 | 0.0048 | |
| GSE45670 | PKP2 | 5318 | 207717_s_at | 0.8965 | 0.0610 | |
| GSE53622 | PKP2 | 5318 | 80727 | -0.1390 | 0.5631 | |
| GSE53624 | PKP2 | 5318 | 80727 | -0.0650 | 0.7422 | |
| GSE63941 | PKP2 | 5318 | 207717_s_at | 3.5717 | 0.0037 | |
| GSE77861 | PKP2 | 5318 | 214154_s_at | -0.0804 | 0.6430 | |
| GSE97050 | PKP2 | 5318 | A_33_P3405728 | 0.4688 | 0.2660 | |
| SRP007169 | PKP2 | 5318 | RNAseq | 2.4188 | 0.0035 | |
| SRP064894 | PKP2 | 5318 | RNAseq | -0.8677 | 0.0350 | |
| SRP133303 | PKP2 | 5318 | RNAseq | -0.1479 | 0.7804 | |
| SRP193095 | PKP2 | 5318 | RNAseq | -0.0063 | 0.9878 | |
| SRP219564 | PKP2 | 5318 | RNAseq | -0.3390 | 0.6379 | |
| TCGA | PKP2 | 5318 | RNAseq | -0.2347 | 0.0740 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PKP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKP2 | 5318 | 10 | 3 | 17 | |
| GSE20123 | PKP2 | 5318 | 10 | 3 | 17 | |
| GSE43470 | PKP2 | 5318 | 7 | 4 | 32 | |
| GSE46452 | PKP2 | 5318 | 10 | 1 | 48 | |
| GSE47630 | PKP2 | 5318 | 12 | 1 | 27 | |
| GSE54993 | PKP2 | 5318 | 0 | 9 | 61 | |
| GSE54994 | PKP2 | 5318 | 8 | 2 | 43 | |
| GSE60625 | PKP2 | 5318 | 0 | 1 | 10 | |
| GSE74703 | PKP2 | 5318 | 7 | 3 | 26 | |
| GSE74704 | PKP2 | 5318 | 6 | 1 | 13 | |
| TCGA | PKP2 | 5318 | 39 | 5 | 52 |
Total number of gains: 109; Total number of losses: 33; Total Number of normals: 346.
Somatic mutations of PKP2:
Generating mutation plots.
Highly correlated genes for PKP2:
Showing top 20/208 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKP2 | MGAT4B | 0.731218 | 3 | 0 | 3 |
| PKP2 | PRELID1 | 0.720583 | 3 | 0 | 3 |
| PKP2 | VDAC3 | 0.719645 | 3 | 0 | 3 |
| PKP2 | ARHGEF5 | 0.718005 | 4 | 0 | 3 |
| PKP2 | MREG | 0.71291 | 4 | 0 | 4 |
| PKP2 | SFT2D3 | 0.709835 | 3 | 0 | 3 |
| PKP2 | PLS1 | 0.702412 | 5 | 0 | 4 |
| PKP2 | TCTN1 | 0.701973 | 3 | 0 | 3 |
| PKP2 | PGAP2 | 0.697271 | 3 | 0 | 3 |
| PKP2 | GTPBP3 | 0.692479 | 3 | 0 | 3 |
| PKP2 | KRTCAP3 | 0.691543 | 3 | 0 | 3 |
| PKP2 | ALDOC | 0.685987 | 3 | 0 | 3 |
| PKP2 | MRPL49 | 0.682646 | 3 | 0 | 3 |
| PKP2 | E2F8 | 0.679682 | 4 | 0 | 4 |
| PKP2 | SPAST | 0.676719 | 4 | 0 | 3 |
| PKP2 | PPP1CC | 0.669075 | 3 | 0 | 3 |
| PKP2 | AGBL5 | 0.666598 | 3 | 0 | 3 |
| PKP2 | TMPO | 0.662973 | 4 | 0 | 3 |
| PKP2 | FBXO11 | 0.659936 | 4 | 0 | 3 |
| PKP2 | PPP2R2D | 0.659391 | 3 | 0 | 3 |
For details and further investigation, click here
