| Full name: F-box protein 11 | Alias Symbol: FBX11|UBR6 | ||
| Type: protein-coding gene | Cytoband: 2p16.3 | ||
| Entrez ID: 80204 | HGNC ID: HGNC:13590 | Ensembl Gene: ENSG00000138081 | OMIM ID: 607871 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of FBXO11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXO11 | 80204 | 222119_s_at | 0.1071 | 0.8018 | |
| GSE20347 | FBXO11 | 80204 | 203255_at | 0.4279 | 0.0082 | |
| GSE23400 | FBXO11 | 80204 | 203255_at | 0.2686 | 0.0023 | |
| GSE26886 | FBXO11 | 80204 | 222119_s_at | -0.0584 | 0.7855 | |
| GSE29001 | FBXO11 | 80204 | 222119_s_at | -0.0845 | 0.8271 | |
| GSE38129 | FBXO11 | 80204 | 203255_at | 0.1000 | 0.6872 | |
| GSE45670 | FBXO11 | 80204 | 222119_s_at | -0.0410 | 0.7445 | |
| GSE53622 | FBXO11 | 80204 | 83213 | 0.1445 | 0.0051 | |
| GSE53624 | FBXO11 | 80204 | 83213 | 0.2282 | 0.0001 | |
| GSE63941 | FBXO11 | 80204 | 203255_at | 1.4705 | 0.0002 | |
| GSE77861 | FBXO11 | 80204 | 222119_s_at | 0.1920 | 0.3889 | |
| GSE97050 | FBXO11 | 80204 | A_23_P356101 | 0.1763 | 0.4101 | |
| SRP007169 | FBXO11 | 80204 | RNAseq | 0.5643 | 0.1586 | |
| SRP008496 | FBXO11 | 80204 | RNAseq | 0.4074 | 0.0597 | |
| SRP064894 | FBXO11 | 80204 | RNAseq | -0.0921 | 0.6504 | |
| SRP133303 | FBXO11 | 80204 | RNAseq | 0.2135 | 0.0503 | |
| SRP159526 | FBXO11 | 80204 | RNAseq | 0.3771 | 0.0706 | |
| SRP193095 | FBXO11 | 80204 | RNAseq | 0.0065 | 0.9293 | |
| SRP219564 | FBXO11 | 80204 | RNAseq | -0.0185 | 0.9383 | |
| TCGA | FBXO11 | 80204 | RNAseq | 0.0281 | 0.5327 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FBXO11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXO11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXO11 | 80204 | 8 | 1 | 21 | |
| GSE20123 | FBXO11 | 80204 | 7 | 1 | 22 | |
| GSE43470 | FBXO11 | 80204 | 5 | 0 | 38 | |
| GSE46452 | FBXO11 | 80204 | 1 | 4 | 54 | |
| GSE47630 | FBXO11 | 80204 | 8 | 0 | 32 | |
| GSE54993 | FBXO11 | 80204 | 0 | 5 | 65 | |
| GSE54994 | FBXO11 | 80204 | 12 | 0 | 41 | |
| GSE60625 | FBXO11 | 80204 | 0 | 3 | 8 | |
| GSE74703 | FBXO11 | 80204 | 5 | 0 | 31 | |
| GSE74704 | FBXO11 | 80204 | 8 | 1 | 11 | |
| TCGA | FBXO11 | 80204 | 36 | 2 | 58 |
Total number of gains: 90; Total number of losses: 17; Total Number of normals: 381.
Somatic mutations of FBXO11:
Generating mutation plots.
Highly correlated genes for FBXO11:
Showing top 20/483 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXO11 | ARHGEF5 | 0.797011 | 3 | 0 | 3 |
| FBXO11 | NIPSNAP1 | 0.795976 | 3 | 0 | 3 |
| FBXO11 | FCF1 | 0.774359 | 3 | 0 | 3 |
| FBXO11 | RSBN1 | 0.773818 | 3 | 0 | 3 |
| FBXO11 | TMEM54 | 0.758378 | 3 | 0 | 3 |
| FBXO11 | MRPS11 | 0.755688 | 3 | 0 | 3 |
| FBXO11 | LMBRD2 | 0.748903 | 3 | 0 | 3 |
| FBXO11 | ORAI1 | 0.747368 | 3 | 0 | 3 |
| FBXO11 | RFX7 | 0.73301 | 3 | 0 | 3 |
| FBXO11 | LCMT2 | 0.727917 | 4 | 0 | 3 |
| FBXO11 | FOPNL | 0.725977 | 3 | 0 | 3 |
| FBXO11 | CTBP2 | 0.723946 | 4 | 0 | 3 |
| FBXO11 | DUSP18 | 0.717802 | 3 | 0 | 3 |
| FBXO11 | AIMP2 | 0.717704 | 3 | 0 | 3 |
| FBXO11 | BIRC6 | 0.716105 | 5 | 0 | 5 |
| FBXO11 | STRBP | 0.710328 | 3 | 0 | 3 |
| FBXO11 | NAPG | 0.709826 | 4 | 0 | 3 |
| FBXO11 | RAD23A | 0.707606 | 3 | 0 | 3 |
| FBXO11 | TMEM135 | 0.705745 | 3 | 0 | 3 |
| FBXO11 | AQR | 0.703698 | 5 | 0 | 4 |
For details and further investigation, click here
