| Full name: HUS1 checkpoint clamp component | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7p12.3 | ||
| Entrez ID: 3364 | HGNC ID: HGNC:5309 | Ensembl Gene: ENSG00000136273 | OMIM ID: 603760 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HUS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HUS1 | 3364 | 204883_s_at | -0.1815 | 0.7789 | |
| GSE20347 | HUS1 | 3364 | 204883_s_at | 0.1980 | 0.3206 | |
| GSE23400 | HUS1 | 3364 | 204883_s_at | 0.1000 | 0.0342 | |
| GSE26886 | HUS1 | 3364 | 204883_s_at | 0.0316 | 0.8871 | |
| GSE29001 | HUS1 | 3364 | 204883_s_at | 0.2656 | 0.3815 | |
| GSE38129 | HUS1 | 3364 | 204883_s_at | 0.4474 | 0.0096 | |
| GSE45670 | HUS1 | 3364 | 204883_s_at | 0.2519 | 0.1172 | |
| GSE53622 | HUS1 | 3364 | 27567 | 0.3352 | 0.0000 | |
| GSE53624 | HUS1 | 3364 | 27567 | 0.3692 | 0.0000 | |
| GSE63941 | HUS1 | 3364 | 204883_s_at | 0.1678 | 0.7244 | |
| GSE77861 | HUS1 | 3364 | 204883_s_at | -0.0511 | 0.8651 | |
| GSE97050 | HUS1 | 3364 | A_33_P3330841 | -0.2522 | 0.5657 | |
| SRP007169 | HUS1 | 3364 | RNAseq | -0.0522 | 0.8975 | |
| SRP008496 | HUS1 | 3364 | RNAseq | -0.2761 | 0.3780 | |
| SRP064894 | HUS1 | 3364 | RNAseq | 0.1502 | 0.2724 | |
| SRP133303 | HUS1 | 3364 | RNAseq | 0.3185 | 0.0200 | |
| SRP159526 | HUS1 | 3364 | RNAseq | 0.4855 | 0.1357 | |
| SRP193095 | HUS1 | 3364 | RNAseq | -0.0501 | 0.5839 | |
| SRP219564 | HUS1 | 3364 | RNAseq | -0.3256 | 0.3922 | |
| TCGA | HUS1 | 3364 | RNAseq | 0.1149 | 0.0549 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HUS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HUS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HUS1 | 3364 | 13 | 0 | 17 | |
| GSE20123 | HUS1 | 3364 | 12 | 0 | 18 | |
| GSE43470 | HUS1 | 3364 | 4 | 0 | 39 | |
| GSE46452 | HUS1 | 3364 | 11 | 1 | 47 | |
| GSE47630 | HUS1 | 3364 | 8 | 1 | 31 | |
| GSE54993 | HUS1 | 3364 | 0 | 8 | 62 | |
| GSE54994 | HUS1 | 3364 | 15 | 3 | 35 | |
| GSE60625 | HUS1 | 3364 | 0 | 0 | 11 | |
| GSE74703 | HUS1 | 3364 | 4 | 0 | 32 | |
| GSE74704 | HUS1 | 3364 | 6 | 0 | 14 | |
| TCGA | HUS1 | 3364 | 51 | 8 | 37 |
Total number of gains: 124; Total number of losses: 21; Total Number of normals: 343.
Somatic mutations of HUS1:
Generating mutation plots.
Highly correlated genes for HUS1:
Showing top 20/297 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HUS1 | SUSD1 | 0.783499 | 3 | 0 | 3 |
| HUS1 | KCNK6 | 0.780743 | 3 | 0 | 3 |
| HUS1 | FAHD1 | 0.776293 | 3 | 0 | 3 |
| HUS1 | MTA3 | 0.771222 | 3 | 0 | 3 |
| HUS1 | SCAPER | 0.766842 | 3 | 0 | 3 |
| HUS1 | TOM1L1 | 0.755392 | 3 | 0 | 3 |
| HUS1 | RNF111 | 0.753563 | 3 | 0 | 3 |
| HUS1 | TTC39B | 0.752174 | 3 | 0 | 3 |
| HUS1 | ADCY7 | 0.750712 | 3 | 0 | 3 |
| HUS1 | WDR20 | 0.746775 | 3 | 0 | 3 |
| HUS1 | SLC9A6 | 0.745223 | 3 | 0 | 3 |
| HUS1 | TAF12 | 0.741609 | 3 | 0 | 3 |
| HUS1 | LYSMD3 | 0.73452 | 3 | 0 | 3 |
| HUS1 | MREG | 0.732174 | 3 | 0 | 3 |
| HUS1 | GANC | 0.73213 | 3 | 0 | 3 |
| HUS1 | AHCY | 0.721369 | 3 | 0 | 3 |
| HUS1 | XIAP | 0.721101 | 3 | 0 | 3 |
| HUS1 | MEGF9 | 0.717405 | 3 | 0 | 3 |
| HUS1 | ARL15 | 0.714545 | 4 | 0 | 4 |
| HUS1 | PIBF1 | 0.714523 | 3 | 0 | 3 |
For details and further investigation, click here
