AKT3

 

Full name: AKT serine/threonine kinase 3 Alias Symbol: PKBG|RAC-gamma|PRKBG
Type: protein-coding gene Cytoband: 1q43-q44
Entrez ID: 10000 HGNC ID: HGNC:393 Ensembl Gene: ENSG00000117020 OMIM ID: 611223
Drug and gene relationship at DGIdb

 

AKT3 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04530Tight junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa04973Carbohydrate digestion and absorption
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of AKT3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 AKT3 10000 212607_at -0.4191 0.7378
GSE20347 AKT3 10000 212607_at 0.3784 0.1339
GSE23400 AKT3 10000 212607_at 0.0936 0.4963
GSE26886 AKT3 10000 212607_at 1.7430 0.0006
GSE29001 AKT3 10000 212607_at 0.7256 0.1469
GSE38129 AKT3 10000 212607_at 0.0749 0.8607
GSE45670 AKT3 10000 212607_at -0.8651 0.0653
GSE53622 AKT3 10000 15097 -0.0591 0.6910
GSE53624 AKT3 10000 15097 0.2795 0.0132
GSE63941 AKT3 10000 212607_at -1.4187 0.2384
GSE77861 AKT3 10000 242876_at -0.0269 0.8067
GSE97050 AKT3 10000 A_23_P160354 -0.4347 0.2764
SRP007169 AKT3 10000 RNAseq 1.4516 0.0181
SRP008496 AKT3 10000 RNAseq 1.4743 0.0021
SRP064894 AKT3 10000 RNAseq 0.2217 0.4080
SRP133303 AKT3 10000 RNAseq -0.1058 0.7001
SRP159526 AKT3 10000 RNAseq 0.5454 0.0766
SRP193095 AKT3 10000 RNAseq 0.8807 0.0003
SRP219564 AKT3 10000 RNAseq -0.3666 0.5772
TCGA AKT3 10000 RNAseq -0.1225 0.3688

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by AKT3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of AKT3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 AKT3 10000 7 1 22
GSE20123 AKT3 10000 7 1 22
GSE43470 AKT3 10000 6 2 35
GSE46452 AKT3 10000 4 2 53
GSE47630 AKT3 10000 15 0 25
GSE54993 AKT3 10000 1 6 63
GSE54994 AKT3 10000 18 0 35
GSE60625 AKT3 10000 0 0 11
GSE74703 AKT3 10000 6 1 29
GSE74704 AKT3 10000 2 0 18
TCGA AKT3 10000 46 4 46

Total number of gains: 112; Total number of losses: 17; Total Number of normals: 359.  

 

Somatic mutations of AKT3:

 

Generating mutation plots.

 

Highly correlated genes for AKT3:

 

Showing top 20/877 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
AKT3KCND30.772607303
AKT3MPDZ0.77152810010
AKT3MYADM0.765818403
AKT3ZEB10.762786303
AKT3MAP1B0.75957710010
AKT3ARL20.752274303
AKT3CREB30.748345403
AKT3PLEKHO10.74364811010
AKT3APLP20.737209404
AKT3TCEA20.736896807
AKT3WSCD20.735712303
AKT3LAMA40.73318410010
AKT3MCAM0.727306808
AKT3EPB41L20.72657611011
AKT3FXYD60.7265611009
AKT3MSRB20.722039303
AKT3DPYSL30.71914610010
AKT3TSPAN180.713738705
AKT3LNP10.710714303
AKT3FERMT20.70743811010

For details and further investigation, click here