EP300

 

Full name: E1A binding protein p300 Alias Symbol: p300|KAT3B
Type: protein-coding gene Cytoband: 22q13.2
Entrez ID: 2033 HGNC ID: HGNC:3373 Ensembl Gene: ENSG00000100393 OMIM ID: 602700
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 22/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

EP300 involved pathways:

KEGG pathway Description View
hsa04024cAMP signaling pathway
hsa04066HIF-1 signaling pathway
hsa04110Cell cycle
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa04350TGF-beta signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04720Long-term potentiation
hsa04916Melanogenesis
hsa04922Glucagon signaling pathway
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05215Prostate cancer

 

Expression of EP300:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EP300 2033 213579_s_at -0.4099 0.3286
GSE20347 EP300 2033 202221_s_at -0.2354 0.1408
GSE23400 EP300 2033 202221_s_at 0.0315 0.5880
GSE26886 EP300 2033 202221_s_at 0.8132 0.0044
GSE29001 EP300 2033 213579_s_at 0.2011 0.2762
GSE38129 EP300 2033 202221_s_at -0.1752 0.1504
GSE45670 EP300 2033 213579_s_at -0.0028 0.9867
GSE53622 EP300 2033 21808 -0.0586 0.3815
GSE53624 EP300 2033 21808 -0.0152 0.8218
GSE63941 EP300 2033 202221_s_at -0.5748 0.4125
GSE77861 EP300 2033 202221_s_at 0.2709 0.2279
GSE97050 EP300 2033 A_23_P40693 0.2739 0.2372
SRP007169 EP300 2033 RNAseq 1.2954 0.0053
SRP008496 EP300 2033 RNAseq 0.8298 0.0060
SRP064894 EP300 2033 RNAseq 0.0007 0.9984
SRP133303 EP300 2033 RNAseq -0.0069 0.9518
SRP159526 EP300 2033 RNAseq -0.1230 0.4876
SRP193095 EP300 2033 RNAseq 0.0158 0.8622
SRP219564 EP300 2033 RNAseq -0.2549 0.5205
TCGA EP300 2033 RNAseq -0.0015 0.9705

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by EP300 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EP300:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EP300 2033 6 5 19
GSE20123 EP300 2033 6 4 20
GSE43470 EP300 2033 4 6 33
GSE46452 EP300 2033 31 2 26
GSE47630 EP300 2033 9 4 27
GSE54993 EP300 2033 3 6 61
GSE54994 EP300 2033 11 8 34
GSE60625 EP300 2033 5 0 6
GSE74703 EP300 2033 4 4 28
GSE74704 EP300 2033 3 2 15
TCGA EP300 2033 26 14 56

Total number of gains: 108; Total number of losses: 55; Total Number of normals: 325.  

 

Somatic mutations of EP300:

 

Generating mutation plots.

 

Highly correlated genes for EP300:

 

Showing top 20/105 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EP300NACC10.816021303
EP300FAF20.774513303
EP300CHERP0.757572303
EP300CIR10.735276303
EP300SCAF110.727726303
EP300RAD23A0.726166303
EP300NTPCR0.725227303
EP300C12orf450.723897303
EP300LDB10.705261303
EP300KIAA09300.705187303
EP300ARL20.701676303
EP300ZC3H30.698558303
EP300PPP1R16A0.696416303
EP300AHCTF10.695664403
EP300ZNF354A0.688918303
EP300ZNF1400.688504303
EP300TOP1MT0.679454303
EP300CHD10.673977303
EP300MLH30.673455303
EP300HMG20B0.672617303

For details and further investigation, click here