| Full name: acid sensing ion channel subunit family member 5 | Alias Symbol: INAC|HINAC | ||
| Type: protein-coding gene | Cytoband: 4q32.1 | ||
| Entrez ID: 51802 | HGNC ID: HGNC:17537 | Ensembl Gene: ENSG00000256394 | OMIM ID: 616693 |
| Drug and gene relationship at DGIdb | |||
ASIC5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of ASIC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASIC5 | 51802 | 1564504_at | -0.0248 | 0.9204 | |
| GSE26886 | ASIC5 | 51802 | 1564504_at | -0.0731 | 0.4190 | |
| GSE45670 | ASIC5 | 51802 | 1564504_at | 0.0093 | 0.8996 | |
| GSE53622 | ASIC5 | 51802 | 23175 | -2.0059 | 0.0000 | |
| GSE53624 | ASIC5 | 51802 | 23175 | -3.2122 | 0.0000 | |
| GSE63941 | ASIC5 | 51802 | 1564504_at | 0.1358 | 0.1913 | |
| GSE77861 | ASIC5 | 51802 | 1564504_at | 0.0179 | 0.8245 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ASIC5 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ASIC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASIC5 | 51802 | 0 | 14 | 16 | |
| GSE20123 | ASIC5 | 51802 | 0 | 14 | 16 | |
| GSE43470 | ASIC5 | 51802 | 0 | 14 | 29 | |
| GSE46452 | ASIC5 | 51802 | 1 | 36 | 22 | |
| GSE47630 | ASIC5 | 51802 | 0 | 23 | 17 | |
| GSE54993 | ASIC5 | 51802 | 10 | 0 | 60 | |
| GSE54994 | ASIC5 | 51802 | 1 | 12 | 40 | |
| GSE60625 | ASIC5 | 51802 | 0 | 1 | 10 | |
| GSE74703 | ASIC5 | 51802 | 0 | 12 | 24 | |
| GSE74704 | ASIC5 | 51802 | 0 | 7 | 13 | |
| TCGA | ASIC5 | 51802 | 10 | 36 | 50 |
Total number of gains: 22; Total number of losses: 169; Total Number of normals: 297.
Somatic mutations of ASIC5:
Generating mutation plots.
Highly correlated genes for ASIC5:
Showing top 20/90 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASIC5 | RMND5B | 0.752992 | 3 | 0 | 3 |
| ASIC5 | LAMB4 | 0.748885 | 3 | 0 | 3 |
| ASIC5 | PLEKHN1 | 0.747086 | 3 | 0 | 3 |
| ASIC5 | CRNN | 0.728272 | 3 | 0 | 3 |
| ASIC5 | FAM218A | 0.728219 | 3 | 0 | 3 |
| ASIC5 | CLPS | 0.720093 | 3 | 0 | 3 |
| ASIC5 | SFTPB | 0.715077 | 3 | 0 | 3 |
| ASIC5 | LPIN1 | 0.712774 | 3 | 0 | 3 |
| ASIC5 | CXCR2 | 0.705949 | 3 | 0 | 3 |
| ASIC5 | SYNPO2L | 0.697105 | 3 | 0 | 3 |
| ASIC5 | C19orf57 | 0.692586 | 3 | 0 | 3 |
| ASIC5 | ARHGAP27 | 0.69059 | 3 | 0 | 3 |
| ASIC5 | MRVI1-AS1 | 0.686719 | 3 | 0 | 3 |
| ASIC5 | ANKRD31 | 0.686402 | 3 | 0 | 3 |
| ASIC5 | CRB1 | 0.684375 | 3 | 0 | 3 |
| ASIC5 | CDX1 | 0.681892 | 4 | 0 | 4 |
| ASIC5 | FBXW7 | 0.678774 | 3 | 0 | 3 |
| ASIC5 | OTOF | 0.672936 | 4 | 0 | 3 |
| ASIC5 | IQCF1 | 0.662952 | 4 | 0 | 3 |
| ASIC5 | TF | 0.661199 | 4 | 0 | 3 |
For details and further investigation, click here
