| Full name: cornulin | Alias Symbol: SEP53 | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 49860 | HGNC ID: HGNC:1230 | Ensembl Gene: ENSG00000143536 | OMIM ID: 611312 |
| Drug and gene relationship at DGIdb | |||
Expression of CRNN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRNN | 49860 | 220090_at | -5.1522 | 0.0229 | |
| GSE20347 | CRNN | 49860 | 220090_at | -6.2800 | 0.0000 | |
| GSE23400 | CRNN | 49860 | 220090_at | -4.6177 | 0.0000 | |
| GSE26886 | CRNN | 49860 | 220090_at | -9.1461 | 0.0000 | |
| GSE29001 | CRNN | 49860 | 220090_at | -7.1727 | 0.0000 | |
| GSE38129 | CRNN | 49860 | 220090_at | -4.8987 | 0.0000 | |
| GSE45670 | CRNN | 49860 | 220090_at | -2.0058 | 0.0493 | |
| GSE53622 | CRNN | 49860 | 118403 | -3.5551 | 0.0000 | |
| GSE53624 | CRNN | 49860 | 118403 | -3.7229 | 0.0000 | |
| GSE63941 | CRNN | 49860 | 220090_at | 0.0437 | 0.7628 | |
| GSE77861 | CRNN | 49860 | 220090_at | -4.0612 | 0.0443 | |
| GSE97050 | CRNN | 49860 | A_23_P115202 | -3.9052 | 0.0502 | |
| SRP007169 | CRNN | 49860 | RNAseq | -12.9935 | 0.0000 | |
| SRP008496 | CRNN | 49860 | RNAseq | -8.8330 | 0.0000 | |
| SRP064894 | CRNN | 49860 | RNAseq | -5.2566 | 0.0000 | |
| SRP133303 | CRNN | 49860 | RNAseq | -8.0108 | 0.0000 | |
| SRP159526 | CRNN | 49860 | RNAseq | -7.9678 | 0.0000 | |
| SRP219564 | CRNN | 49860 | RNAseq | -5.9219 | 0.0001 | |
| TCGA | CRNN | 49860 | RNAseq | -0.4900 | 0.5282 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by CRNN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRNN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRNN | 49860 | 14 | 0 | 16 | |
| GSE20123 | CRNN | 49860 | 14 | 0 | 16 | |
| GSE43470 | CRNN | 49860 | 6 | 2 | 35 | |
| GSE46452 | CRNN | 49860 | 2 | 1 | 56 | |
| GSE47630 | CRNN | 49860 | 15 | 0 | 25 | |
| GSE54993 | CRNN | 49860 | 0 | 4 | 66 | |
| GSE54994 | CRNN | 49860 | 15 | 1 | 37 | |
| GSE60625 | CRNN | 49860 | 0 | 0 | 11 | |
| GSE74703 | CRNN | 49860 | 6 | 1 | 29 | |
| GSE74704 | CRNN | 49860 | 7 | 0 | 13 | |
| TCGA | CRNN | 49860 | 39 | 2 | 55 |
Total number of gains: 118; Total number of losses: 11; Total Number of normals: 359.
Somatic mutations of CRNN:
Generating mutation plots.
Highly correlated genes for CRNN:
Showing top 20/1615 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRNN | TMPRSS11B | 0.955733 | 8 | 0 | 8 |
| CRNN | MAL | 0.951024 | 12 | 0 | 12 |
| CRNN | SPINK5 | 0.936286 | 12 | 0 | 12 |
| CRNN | CYSRT1 | 0.923436 | 6 | 0 | 6 |
| CRNN | SLURP1 | 0.919967 | 12 | 0 | 12 |
| CRNN | TGM3 | 0.916962 | 12 | 0 | 12 |
| CRNN | SCEL | 0.913179 | 12 | 0 | 12 |
| CRNN | KRT4 | 0.910204 | 12 | 0 | 12 |
| CRNN | SPINK7 | 0.907325 | 8 | 0 | 8 |
| CRNN | CAPN14 | 0.904927 | 7 | 0 | 7 |
| CRNN | PRSS27 | 0.904236 | 8 | 0 | 8 |
| CRNN | MUC21 | 0.897517 | 3 | 0 | 3 |
| CRNN | CLCA4 | 0.890564 | 13 | 0 | 12 |
| CRNN | TMPRSS11E | 0.88921 | 11 | 0 | 11 |
| CRNN | VSIG10L | 0.885653 | 7 | 0 | 7 |
| CRNN | PPL | 0.879596 | 12 | 0 | 12 |
| CRNN | CLIC3 | 0.877782 | 10 | 0 | 10 |
| CRNN | KRT13 | 0.876593 | 12 | 0 | 12 |
| CRNN | KLK13 | 0.876249 | 12 | 0 | 12 |
| CRNN | KRT78 | 0.876062 | 8 | 0 | 8 |
For details and further investigation, click here
