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Severity: Warning

Message: exec(): Unable to fork [Rscript361 /data/webapp/var/www/html/ESCCdb/application/scripts/R/getGeneSurvival_GSE.R ASNS /data/webapp/var/www/html/ESCCdb/application/scripts/R/GSE53624_EXP_survival.RData application/survivalPlots/GSE53624]

Filename: controllers/Result_pages.php

Line Number: 123

Backtrace:

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 123
Function: exec

File: /data/webapp/var/www/html/ESCCdb/application/controllers/Result_pages.php
Line: 387
Function: drawSurvPlot

File: /data/webapp/var/www/html/ESCCdb/index.php
Line: 315
Function: require_once

Multi-Omics Database of ESCC

 

ASNS

 

Full name: asparagine synthetase (glutamine-hydrolyzing) Alias Symbol: 
Type: protein-coding gene Cytoband: 7q21.3
Entrez ID: 440 HGNC ID: HGNC:753 Ensembl Gene: ENSG00000070669 OMIM ID: 108370
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ASNS:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ASNS 440 205047_s_at 0.5127 0.3717
GSE20347 ASNS 440 205047_s_at 1.2832 0.0001
GSE23400 ASNS 440 205047_s_at 0.5930 0.0000
GSE26886 ASNS 440 205047_s_at 1.2462 0.0001
GSE29001 ASNS 440 205047_s_at 0.4223 0.3908
GSE38129 ASNS 440 205047_s_at 1.1127 0.0000
GSE45670 ASNS 440 205047_s_at 0.6471 0.1178
GSE63941 ASNS 440 205047_s_at 1.1899 0.3621
GSE77861 ASNS 440 205047_s_at 1.4063 0.0037
GSE97050 ASNS 440 A_23_P145694 0.2748 0.4601
SRP007169 ASNS 440 RNAseq 2.0783 0.0003
SRP008496 ASNS 440 RNAseq 1.9339 0.0001
SRP064894 ASNS 440 RNAseq 0.7345 0.0031
SRP133303 ASNS 440 RNAseq 2.0849 0.0001
SRP159526 ASNS 440 RNAseq 1.3236 0.0003
SRP193095 ASNS 440 RNAseq 1.0335 0.0000
SRP219564 ASNS 440 RNAseq 0.9986 0.0150
TCGA ASNS 440 RNAseq -0.0384 0.7317

Upregulated datasets: 9; Downregulated datasets: 0.  

 

Survival by ASNS expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of ASNS:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ASNS 440 12 0 18
GSE20123 ASNS 440 12 0 18
GSE43470 ASNS 440 6 2 35
GSE46452 ASNS 440 12 0 47
GSE47630 ASNS 440 9 2 29
GSE54993 ASNS 440 1 8 61
GSE54994 ASNS 440 16 5 32
GSE60625 ASNS 440 0 5 6
GSE74703 ASNS 440 6 1 29
GSE74704 ASNS 440 9 0 11
TCGA ASNS 440 53 6 37

Total number of gains: 136; Total number of losses: 29; Total Number of normals: 323.  

 

Somatic mutations of ASNS:

 

Generating mutation plots.

 

Highly correlated genes for ASNS:

 

Showing top 20/782 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ASNSSLC39A140.689863504
ASNSCENPV0.685124303
ASNSB3GAT30.681321404
ASNSPPP1R350.678105403
ASNSITGA60.677203404
ASNSADA0.677179303
ASNSACOT90.675488505
ASNSNABP20.673003404
ASNSTNFRSF10B0.670666303
ASNSRAVER10.668483303
ASNSDERL20.66674303
ASNSCHST150.661821403
ASNSCDCA7L0.660988303
ASNSTMEM38B0.660374605
ASNSTRAM20.660255504
ASNSTAF60.659689605
ASNSCOL4A20.653607504
ASNSKXD10.653154605
ASNSRPS19BP10.651327303
ASNSENO20.649578404

For details and further investigation, click here