| Full name: integrin subunit alpha 6 | Alias Symbol: CD49f | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 3655 | HGNC ID: HGNC:6142 | Ensembl Gene: ENSG00000091409 | OMIM ID: 147556 |
| Drug and gene relationship at DGIdb | |||
ITGA6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of ITGA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGA6 | 3655 | 201656_at | 1.7082 | 0.0247 | |
| GSE20347 | ITGA6 | 3655 | 201656_at | 1.5366 | 0.0000 | |
| GSE23400 | ITGA6 | 3655 | 201656_at | 1.5872 | 0.0000 | |
| GSE26886 | ITGA6 | 3655 | 201656_at | 1.3707 | 0.0002 | |
| GSE29001 | ITGA6 | 3655 | 201656_at | 1.3324 | 0.0001 | |
| GSE38129 | ITGA6 | 3655 | 201656_at | 1.5600 | 0.0000 | |
| GSE45670 | ITGA6 | 3655 | 201656_at | 1.4983 | 0.0001 | |
| GSE53622 | ITGA6 | 3655 | 32011 | 2.3551 | 0.0000 | |
| GSE53624 | ITGA6 | 3655 | 32011 | 1.9663 | 0.0000 | |
| GSE63941 | ITGA6 | 3655 | 201656_at | 3.3597 | 0.0000 | |
| GSE77861 | ITGA6 | 3655 | 201656_at | 1.2824 | 0.0184 | |
| GSE97050 | ITGA6 | 3655 | A_33_P3231447 | 1.5548 | 0.1287 | |
| SRP007169 | ITGA6 | 3655 | RNAseq | 2.4432 | 0.0000 | |
| SRP008496 | ITGA6 | 3655 | RNAseq | 2.4953 | 0.0000 | |
| SRP064894 | ITGA6 | 3655 | RNAseq | 1.8437 | 0.0000 | |
| SRP133303 | ITGA6 | 3655 | RNAseq | 2.1793 | 0.0000 | |
| SRP159526 | ITGA6 | 3655 | RNAseq | 1.6951 | 0.0000 | |
| SRP193095 | ITGA6 | 3655 | RNAseq | 1.6425 | 0.0000 | |
| SRP219564 | ITGA6 | 3655 | RNAseq | 1.2725 | 0.0198 | |
| TCGA | ITGA6 | 3655 | RNAseq | 0.2331 | 0.0067 |
Upregulated datasets: 18; Downregulated datasets: 0.
Survival by ITGA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITGA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGA6 | 3655 | 9 | 0 | 21 | |
| GSE20123 | ITGA6 | 3655 | 9 | 0 | 21 | |
| GSE43470 | ITGA6 | 3655 | 6 | 1 | 36 | |
| GSE46452 | ITGA6 | 3655 | 1 | 4 | 54 | |
| GSE47630 | ITGA6 | 3655 | 5 | 3 | 32 | |
| GSE54993 | ITGA6 | 3655 | 0 | 5 | 65 | |
| GSE54994 | ITGA6 | 3655 | 11 | 3 | 39 | |
| GSE60625 | ITGA6 | 3655 | 0 | 3 | 8 | |
| GSE74703 | ITGA6 | 3655 | 5 | 1 | 30 | |
| GSE74704 | ITGA6 | 3655 | 5 | 0 | 15 | |
| TCGA | ITGA6 | 3655 | 28 | 6 | 62 |
Total number of gains: 79; Total number of losses: 26; Total Number of normals: 383.
Somatic mutations of ITGA6:
Generating mutation plots.
Highly correlated genes for ITGA6:
Showing top 20/1660 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGA6 | KIF14 | 0.801408 | 12 | 0 | 12 |
| ITGA6 | SNAI2 | 0.787264 | 9 | 0 | 9 |
| ITGA6 | CKS1B | 0.786715 | 12 | 0 | 12 |
| ITGA6 | LAMC2 | 0.785841 | 13 | 0 | 12 |
| ITGA6 | PLAU | 0.776693 | 12 | 0 | 11 |
| ITGA6 | LAMB3 | 0.775121 | 13 | 0 | 12 |
| ITGA6 | ECT2 | 0.767684 | 12 | 0 | 12 |
| ITGA6 | MMP1 | 0.758001 | 12 | 0 | 11 |
| ITGA6 | PSME4 | 0.757036 | 11 | 0 | 11 |
| ITGA6 | RUNX1 | 0.751139 | 3 | 0 | 3 |
| ITGA6 | ITGB4 | 0.74936 | 12 | 0 | 12 |
| ITGA6 | MYO1B | 0.748601 | 12 | 0 | 12 |
| ITGA6 | CBX3 | 0.74384 | 11 | 0 | 10 |
| ITGA6 | ATP1B3 | 0.742525 | 11 | 0 | 11 |
| ITGA6 | KIF4A | 0.741878 | 11 | 0 | 10 |
| ITGA6 | IGF2BP2 | 0.740316 | 11 | 0 | 10 |
| ITGA6 | TGFBI | 0.739887 | 12 | 0 | 12 |
| ITGA6 | CDH3 | 0.738374 | 11 | 0 | 10 |
| ITGA6 | RFC4 | 0.738206 | 12 | 0 | 12 |
| ITGA6 | ITPR3 | 0.736324 | 12 | 0 | 12 |
For details and further investigation, click here
