Full name: adenosine deaminase	Alias Symbol:
Type: protein-coding gene	Cytoband: 20q13.12
Entrez ID: 100	HGNC ID: HGNC:186	Ensembl Gene: ENSG00000196839	OMIM ID: 608958
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of ADA:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ADA	100	204639_at	1.4248	0.0445	Show
GSE20347	ADA	100	204639_at	1.0707	0.0006	Show
GSE23400	ADA	100	204639_at	0.5955	0.0000	Show
GSE26886	ADA	100	204639_at	2.3896	0.0000	Show
GSE29001	ADA	100	204639_at	1.2531	0.0013	Show
GSE38129	ADA	100	204639_at	0.9992	0.0003	Show
GSE45670	ADA	100	204639_at	1.4641	0.0000	Show
GSE53622	ADA	100	79684	1.0145	0.0000	Show
GSE53624	ADA	100	58828	1.4657	0.0000	Show
GSE63941	ADA	100	204639_at	0.4604	0.6699	Show
GSE77861	ADA	100	204639_at	0.5489	0.0657	Show
GSE97050	ADA	100	A_23_P210482	0.7856	0.1351	Show
SRP007169	ADA	100	RNAseq	1.8972	0.0041	Show
SRP008496	ADA	100	RNAseq	1.5944	0.0016	Show
SRP064894	ADA	100	RNAseq	1.2626	0.0000	Show
SRP133303	ADA	100	RNAseq	1.1242	0.0000	Show
SRP159526	ADA	100	RNAseq	1.3339	0.0189	Show
SRP193095	ADA	100	RNAseq	0.3747	0.2121	Show
SRP219564	ADA	100	RNAseq	1.3881	0.0087	Show
TCGA	ADA	100	RNAseq	-0.0483	0.7054	Show

Upregulated datasets: 13; Downregulated datasets: 0.  Download Data

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Survival by ADA expression:

 

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Copy number change of ADA:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	ADA	100	13	1	16	Show
GSE20123	ADA	100	13	1	16	Show
GSE43470	ADA	100	12	2	29	Show
GSE46452	ADA	100	29	0	30	Show
GSE47630	ADA	100	24	1	15	Show
GSE54993	ADA	100	0	17	53	Show
GSE54994	ADA	100	25	0	28	Show
GSE60625	ADA	100	0	0	11	Show
GSE74703	ADA	100	10	2	24	Show
GSE74704	ADA	100	9	0	11	Show
TCGA	ADA	100	46	3	47	Show

Total number of gains: 181; Total number of losses: 27; Total Number of normals: 280.  Download Data

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Somatic mutations of ADA:

 

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Highly correlated genes for ADA:

 

Showing top 20/1925 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ADA	PDIA5	0.760429	3	0	3
ADA	HELB	0.737243	3	0	3
ADA	C12orf75	0.735697	7	0	7
ADA	ZNF469	0.721341	6	0	5
ADA	DCBLD1	0.719904	7	0	7
ADA	XPR1	0.718302	7	0	7
ADA	DPYSL2	0.716955	3	0	3
ADA	WDR66	0.715334	7	0	7
ADA	TTYH3	0.71131	7	0	7
ADA	ALPK2	0.710233	3	0	3
ADA	FAM89A	0.709172	3	0	3
ADA	FMNL2	0.708822	8	0	7
ADA	ARPC1B	0.70854	11	0	10
ADA	GRAMD1A	0.708207	6	0	6
ADA	KCTD13	0.703975	3	0	3
ADA	MMP1	0.703649	11	0	11
ADA	PLAU	0.701182	11	0	11
ADA	WDR54	0.700925	7	0	6
ADA	SPRR2G	0.700731	3	0	3
ADA	IFNGR1	0.700529	9	0	9

For details and further investigation, click here