| Full name: mediator complex subunit 10 | Alias Symbol: TRG20|L6|MGC5309|NUT2 | ||
| Type: protein-coding gene | Cytoband: 5p15.31 | ||
| Entrez ID: 84246 | HGNC ID: HGNC:28760 | Ensembl Gene: ENSG00000133398 | OMIM ID: 612382 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MED10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MED10 | 84246 | 223247_at | 0.5483 | 0.1043 | |
| GSE26886 | MED10 | 84246 | 223247_at | 0.1483 | 0.3766 | |
| GSE45670 | MED10 | 84246 | 223247_at | 0.4226 | 0.0217 | |
| GSE53622 | MED10 | 84246 | 74773 | 0.5257 | 0.0000 | |
| GSE53624 | MED10 | 84246 | 74773 | 0.6444 | 0.0000 | |
| GSE63941 | MED10 | 84246 | 223247_at | 0.5555 | 0.1454 | |
| GSE77861 | MED10 | 84246 | 223247_at | 0.9947 | 0.0042 | |
| GSE97050 | MED10 | 84246 | A_23_P124024 | 0.4922 | 0.1403 | |
| SRP007169 | MED10 | 84246 | RNAseq | 0.4263 | 0.2807 | |
| SRP008496 | MED10 | 84246 | RNAseq | 0.4130 | 0.1094 | |
| SRP064894 | MED10 | 84246 | RNAseq | 0.4775 | 0.0070 | |
| SRP133303 | MED10 | 84246 | RNAseq | 0.8778 | 0.0007 | |
| SRP159526 | MED10 | 84246 | RNAseq | 0.3218 | 0.2508 | |
| SRP193095 | MED10 | 84246 | RNAseq | 0.4849 | 0.0031 | |
| SRP219564 | MED10 | 84246 | RNAseq | 0.0958 | 0.7556 | |
| TCGA | MED10 | 84246 | RNAseq | 0.2624 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MED10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MED10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MED10 | 84246 | 13 | 0 | 17 | |
| GSE20123 | MED10 | 84246 | 13 | 0 | 17 | |
| GSE43470 | MED10 | 84246 | 16 | 0 | 27 | |
| GSE46452 | MED10 | 84246 | 6 | 22 | 31 | |
| GSE47630 | MED10 | 84246 | 6 | 11 | 23 | |
| GSE54993 | MED10 | 84246 | 5 | 5 | 60 | |
| GSE54994 | MED10 | 84246 | 29 | 1 | 23 | |
| GSE60625 | MED10 | 84246 | 0 | 0 | 11 | |
| GSE74703 | MED10 | 84246 | 12 | 0 | 24 | |
| GSE74704 | MED10 | 84246 | 11 | 0 | 9 | |
| TCGA | MED10 | 84246 | 57 | 4 | 35 |
Total number of gains: 168; Total number of losses: 43; Total Number of normals: 277.
Somatic mutations of MED10:
Generating mutation plots.
Highly correlated genes for MED10:
Showing top 20/1260 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MED10 | SEMA4C | 0.799909 | 3 | 0 | 3 |
| MED10 | ASXL1 | 0.784749 | 3 | 0 | 3 |
| MED10 | DUS3L | 0.760938 | 3 | 0 | 3 |
| MED10 | RNF13 | 0.755862 | 3 | 0 | 3 |
| MED10 | TMED8 | 0.750392 | 4 | 0 | 4 |
| MED10 | GCLC | 0.744543 | 3 | 0 | 3 |
| MED10 | ATP6V1C1 | 0.743609 | 6 | 0 | 6 |
| MED10 | IGSF6 | 0.740916 | 3 | 0 | 3 |
| MED10 | BMS1 | 0.739734 | 3 | 0 | 3 |
| MED10 | GTPBP6 | 0.738301 | 3 | 0 | 3 |
| MED10 | XPO7 | 0.734679 | 3 | 0 | 3 |
| MED10 | HEXA | 0.731146 | 4 | 0 | 3 |
| MED10 | CD14 | 0.730513 | 4 | 0 | 3 |
| MED10 | PSMC1 | 0.728667 | 4 | 0 | 4 |
| MED10 | ICE1 | 0.727694 | 6 | 0 | 5 |
| MED10 | SS18L1 | 0.727356 | 3 | 0 | 3 |
| MED10 | GNS | 0.727245 | 3 | 0 | 3 |
| MED10 | U2SURP | 0.726076 | 4 | 0 | 4 |
| MED10 | EXTL3 | 0.725697 | 4 | 0 | 3 |
| MED10 | LRRC8E | 0.725451 | 3 | 0 | 3 |
For details and further investigation, click here
