ATR

 

Full name: ATR serine/threonine kinase Alias Symbol: FRP1|SCKL|SCKL1|MEC1
Type: protein-coding gene Cytoband: 3q23
Entrez ID: 545 HGNC ID: HGNC:882 Ensembl Gene: ENSG00000175054 OMIM ID: 601215
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 250/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ATR involved pathways:

KEGG pathway Description View
hsa03460Fanconi anemia pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05166HTLV-I infection

 

Expression of ATR:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ATR 545 209903_s_at 0.8863 0.1223
GSE20347 ATR 545 209903_s_at 0.9685 0.0000
GSE23400 ATR 545 209903_s_at 1.1667 0.0000
GSE26886 ATR 545 209903_s_at 1.1243 0.0000
GSE29001 ATR 545 209903_s_at 0.9598 0.0010
GSE38129 ATR 545 209903_s_at 0.9609 0.0000
GSE45670 ATR 545 209903_s_at 0.7809 0.0000
GSE53622 ATR 545 53886 0.5880 0.0000
GSE53624 ATR 545 53886 0.6346 0.0000
GSE63941 ATR 545 209903_s_at 0.0085 0.9862
GSE77861 ATR 545 209903_s_at 0.8140 0.0042
GSE97050 ATR 545 A_23_P136058 0.6493 0.1237
SRP007169 ATR 545 RNAseq 1.4849 0.0002
SRP008496 ATR 545 RNAseq 1.5330 0.0000
SRP064894 ATR 545 RNAseq 0.5434 0.0260
SRP133303 ATR 545 RNAseq 0.7505 0.0000
SRP159526 ATR 545 RNAseq 0.6909 0.0452
SRP193095 ATR 545 RNAseq 0.6609 0.0000
SRP219564 ATR 545 RNAseq 0.6042 0.0429
TCGA ATR 545 RNAseq 0.2297 0.0001

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by ATR expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ATR:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ATR 545 21 0 9
GSE20123 ATR 545 21 0 9
GSE43470 ATR 545 22 0 21
GSE46452 ATR 545 15 4 40
GSE47630 ATR 545 19 3 18
GSE54993 ATR 545 1 8 61
GSE54994 ATR 545 34 1 18
GSE60625 ATR 545 0 6 5
GSE74703 ATR 545 19 0 17
GSE74704 ATR 545 14 0 6
TCGA ATR 545 63 4 29

Total number of gains: 229; Total number of losses: 26; Total Number of normals: 233.  

 

Somatic mutations of ATR:

 

Generating mutation plots.

 

Highly correlated genes for ATR:

 

Showing top 20/2181 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ATRACTL6A0.8283311011
ATRU2SURP0.82372110010
ATRTOPBP10.816412011
ATRCDC42SE20.791899303
ATRLRRC580.788984606
ATRECT20.7844710010
ATRHNRNPUL10.779641303
ATRATP2C10.77801812012
ATRKLHL50.775228303
ATRZNF1210.774996505
ATRDNAJB110.771889606
ATRHPS30.771657505
ATRFZD60.761999909
ATRAURKAIP10.760091303
ATRRASA20.758353403
ATRGATC0.758151404
ATRPLXNA10.75630511011
ATRCPSF60.75602311011
ATRMBD40.75541911010
ATRHLTF0.75449511010

For details and further investigation, click here