| Full name: autophagy related 4D cysteine peptidase | Alias Symbol: APG4-D | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 84971 | HGNC ID: HGNC:20789 | Ensembl Gene: ENSG00000130734 | OMIM ID: 611340 |
| Drug and gene relationship at DGIdb | |||
Expression of ATG4D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATG4D | 84971 | 226871_s_at | 0.4382 | 0.2190 | |
| GSE26886 | ATG4D | 84971 | 226871_s_at | 0.3670 | 0.0393 | |
| GSE45670 | ATG4D | 84971 | 226871_s_at | 0.2408 | 0.1036 | |
| GSE53622 | ATG4D | 84971 | 73287 | -0.1693 | 0.0635 | |
| GSE53624 | ATG4D | 84971 | 73287 | -0.1102 | 0.0947 | |
| GSE63941 | ATG4D | 84971 | 226871_s_at | 0.5673 | 0.0661 | |
| GSE77861 | ATG4D | 84971 | 226871_s_at | 0.1989 | 0.2893 | |
| GSE97050 | ATG4D | 84971 | A_23_P101342 | -0.0381 | 0.8956 | |
| SRP007169 | ATG4D | 84971 | RNAseq | -0.4936 | 0.2553 | |
| SRP008496 | ATG4D | 84971 | RNAseq | -0.4294 | 0.1912 | |
| SRP064894 | ATG4D | 84971 | RNAseq | -0.0313 | 0.9085 | |
| SRP133303 | ATG4D | 84971 | RNAseq | -0.1030 | 0.6144 | |
| SRP159526 | ATG4D | 84971 | RNAseq | 0.0317 | 0.9086 | |
| SRP193095 | ATG4D | 84971 | RNAseq | -0.2686 | 0.0381 | |
| SRP219564 | ATG4D | 84971 | RNAseq | -0.0396 | 0.9305 | |
| TCGA | ATG4D | 84971 | RNAseq | 0.1645 | 0.0148 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATG4D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATG4D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATG4D | 84971 | 4 | 3 | 23 | |
| GSE20123 | ATG4D | 84971 | 3 | 1 | 26 | |
| GSE43470 | ATG4D | 84971 | 3 | 6 | 34 | |
| GSE46452 | ATG4D | 84971 | 47 | 1 | 11 | |
| GSE47630 | ATG4D | 84971 | 4 | 7 | 29 | |
| GSE54993 | ATG4D | 84971 | 16 | 3 | 51 | |
| GSE54994 | ATG4D | 84971 | 7 | 13 | 33 | |
| GSE60625 | ATG4D | 84971 | 9 | 0 | 2 | |
| GSE74703 | ATG4D | 84971 | 3 | 4 | 29 | |
| GSE74704 | ATG4D | 84971 | 0 | 1 | 19 | |
| TCGA | ATG4D | 84971 | 15 | 14 | 67 |
Total number of gains: 111; Total number of losses: 53; Total Number of normals: 324.
Somatic mutations of ATG4D:
Generating mutation plots.
Highly correlated genes for ATG4D:
Showing top 20/187 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATG4D | ZDHHC23 | 0.765943 | 3 | 0 | 3 |
| ATG4D | C19orf53 | 0.727099 | 3 | 0 | 3 |
| ATG4D | ATP13A2 | 0.721492 | 3 | 0 | 3 |
| ATG4D | SURF2 | 0.718336 | 5 | 0 | 5 |
| ATG4D | BAX | 0.716125 | 3 | 0 | 3 |
| ATG4D | NRF1 | 0.712916 | 4 | 0 | 4 |
| ATG4D | STK11 | 0.704149 | 4 | 0 | 3 |
| ATG4D | WDR83 | 0.691091 | 4 | 0 | 4 |
| ATG4D | POLQ | 0.682585 | 4 | 0 | 3 |
| ATG4D | ITGA2B | 0.677868 | 3 | 0 | 3 |
| ATG4D | TTC32 | 0.674969 | 3 | 0 | 3 |
| ATG4D | OXLD1 | 0.66164 | 3 | 0 | 3 |
| ATG4D | TNIP2 | 0.66041 | 3 | 0 | 3 |
| ATG4D | ATXN7L2 | 0.660146 | 3 | 0 | 3 |
| ATG4D | REXO4 | 0.659794 | 3 | 0 | 3 |
| ATG4D | HOOK2 | 0.654753 | 5 | 0 | 4 |
| ATG4D | LRFN4 | 0.652572 | 4 | 0 | 3 |
| ATG4D | C12orf54 | 0.648748 | 4 | 0 | 3 |
| ATG4D | TMEM102 | 0.647183 | 4 | 0 | 3 |
| ATG4D | TUT1 | 0.646376 | 4 | 0 | 4 |
For details and further investigation, click here
