POLQ

 

Full name: DNA polymerase theta Alias Symbol: POLH
Type: protein-coding gene Cytoband: 3q13.33
Entrez ID: 10721 HGNC ID: HGNC:9186 Ensembl Gene: ENSG00000051341 OMIM ID: 604419
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 18/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of POLQ:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLQ 10721 219510_at 0.9580 0.0993
GSE20347 POLQ 10721 219510_at 0.8633 0.0000
GSE23400 POLQ 10721 219510_at 0.1682 0.0039
GSE26886 POLQ 10721 219510_at -0.3988 0.0707
GSE29001 POLQ 10721 219510_at 0.6513 0.0004
GSE38129 POLQ 10721 219510_at 0.9135 0.0000
GSE45670 POLQ 10721 219510_at 0.8091 0.0002
GSE53622 POLQ 10721 89770 0.7166 0.0000
GSE53624 POLQ 10721 89770 0.9399 0.0000
GSE63941 POLQ 10721 219510_at 1.6583 0.0011
GSE77861 POLQ 10721 219510_at 0.1512 0.4527
GSE97050 POLQ 10721 A_23_P218827 0.3816 0.2092
SRP007169 POLQ 10721 RNAseq 1.8620 0.0002
SRP008496 POLQ 10721 RNAseq 1.7864 0.0001
SRP064894 POLQ 10721 RNAseq 0.5415 0.1457
SRP133303 POLQ 10721 RNAseq 1.5646 0.0000
SRP159526 POLQ 10721 RNAseq 1.1499 0.0001
SRP193095 POLQ 10721 RNAseq 1.0548 0.0000
SRP219564 POLQ 10721 RNAseq 0.6862 0.4195
TCGA POLQ 10721 RNAseq 1.2339 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by POLQ expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLQ:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLQ 10721 18 0 12
GSE20123 POLQ 10721 18 0 12
GSE43470 POLQ 10721 20 1 22
GSE46452 POLQ 10721 14 5 40
GSE47630 POLQ 10721 16 5 19
GSE54993 POLQ 10721 2 6 62
GSE54994 POLQ 10721 30 4 19
GSE60625 POLQ 10721 0 6 5
GSE74703 POLQ 10721 16 1 19
GSE74704 POLQ 10721 13 0 7
TCGA POLQ 10721 53 7 36

Total number of gains: 200; Total number of losses: 35; Total Number of normals: 253.  

 

Somatic mutations of POLQ:

 

Generating mutation plots.

 

Highly correlated genes for POLQ:

 

Showing top 20/328 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLQTNFAIP8L10.749287404
POLQUBE2T0.744848505
POLQKIF18B0.735889908
POLQHAUS80.72275606
POLQAURKB0.722342808
POLQBUB1B0.72003807
POLQCDCA50.716892706
POLQCDCA80.71605610010
POLQZDHHC230.710345505
POLQLRWD10.710195303
POLQSAPCD20.709187505
POLQKIF140.706752908
POLQORC60.7063871009
POLQRBM280.70254605
POLQFANCD20.701096505
POLQE2F70.700599606
POLQEXO10.70039111010
POLQSTIL0.6997841109
POLQKNSTRN0.699535505
POLQMCM40.698269908

For details and further investigation, click here