REXO4

 

Full name: REX4 homolog, 3'-5' exonuclease Alias Symbol: hPMC2
Type: protein-coding gene Cytoband: 9q34.2
Entrez ID: 57109 HGNC ID: HGNC:12820 Ensembl Gene: ENSG00000148300 OMIM ID: 602930
Drug and gene relationship at DGIdb

 

Expression of REXO4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 REXO4 57109 218767_at 0.7101 0.0308
GSE20347 REXO4 57109 218767_at 0.5438 0.0000
GSE23400 REXO4 57109 218767_at 0.1995 0.0007
GSE26886 REXO4 57109 218767_at 0.2027 0.2928
GSE29001 REXO4 57109 218767_at 0.5172 0.0023
GSE38129 REXO4 57109 218767_at 0.4795 0.0000
GSE45670 REXO4 57109 218767_at 0.4076 0.0002
GSE53622 REXO4 57109 98814 0.4796 0.0000
GSE53624 REXO4 57109 98814 0.8845 0.0000
GSE63941 REXO4 57109 218767_at 0.4867 0.0977
GSE77861 REXO4 57109 218767_at 0.1037 0.3824
GSE97050 REXO4 57109 A_33_P3272160 0.3177 0.2533
SRP007169 REXO4 57109 RNAseq 0.9099 0.0291
SRP008496 REXO4 57109 RNAseq 1.0670 0.0007
SRP064894 REXO4 57109 RNAseq 1.0680 0.0003
SRP133303 REXO4 57109 RNAseq 0.4687 0.0088
SRP159526 REXO4 57109 RNAseq 0.4599 0.0117
SRP193095 REXO4 57109 RNAseq 0.2327 0.0291
SRP219564 REXO4 57109 RNAseq 0.1655 0.6464
TCGA REXO4 57109 RNAseq 0.2160 0.0005

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by REXO4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of REXO4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 REXO4 57109 5 7 18
GSE20123 REXO4 57109 5 7 18
GSE43470 REXO4 57109 4 7 32
GSE46452 REXO4 57109 6 13 40
GSE47630 REXO4 57109 4 15 21
GSE54993 REXO4 57109 3 3 64
GSE54994 REXO4 57109 12 9 32
GSE60625 REXO4 57109 0 0 11
GSE74703 REXO4 57109 4 5 27
GSE74704 REXO4 57109 3 5 12
TCGA REXO4 57109 28 26 42

Total number of gains: 74; Total number of losses: 97; Total Number of normals: 317.  

 

Somatic mutations of REXO4:

 

Generating mutation plots.

 

Highly correlated genes for REXO4:

 

Showing top 20/1311 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
REXO4SLC19A10.72543303
REXO4YDJC0.711316505
REXO4BCAR10.698255404
REXO4CDCA20.689741303
REXO4CCNA20.688439606
REXO4UBTD10.687124303
REXO4B3GALT60.687111504
REXO4GPRIN10.687101404
REXO4EME10.679912303
REXO4ASB130.679856303
REXO4C21orf580.674702303
REXO4NTMT10.670202505
REXO4DNMT10.66955908
REXO4MRGBP0.667818808
REXO4ZNF6700.664384303
REXO4MYBL20.664211009
REXO4CNTROB0.664083403
REXO4TRIP130.663784907
REXO4CDC25B0.661541908
REXO4UBE2C0.6598491009

For details and further investigation, click here