| Full name: hook microtubule tethering protein 2 | Alias Symbol: HK2 | ||
| Type: protein-coding gene | Cytoband: 19p13.13 | ||
| Entrez ID: 29911 | HGNC ID: HGNC:19885 | Ensembl Gene: ENSG00000095066 | OMIM ID: 607824 |
| Drug and gene relationship at DGIdb | |||
Expression of HOOK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HOOK2 | 29911 | 218780_at | -0.1782 | 0.7114 | |
| GSE20347 | HOOK2 | 29911 | 218780_at | -0.1453 | 0.2739 | |
| GSE23400 | HOOK2 | 29911 | 218780_at | 0.0513 | 0.6086 | |
| GSE26886 | HOOK2 | 29911 | 218780_at | -0.5889 | 0.0026 | |
| GSE29001 | HOOK2 | 29911 | 218780_at | -0.0290 | 0.9263 | |
| GSE38129 | HOOK2 | 29911 | 218780_at | 0.1351 | 0.3640 | |
| GSE45670 | HOOK2 | 29911 | 218780_at | 0.1429 | 0.4494 | |
| GSE53622 | HOOK2 | 29911 | 39544 | -0.3872 | 0.0028 | |
| GSE53624 | HOOK2 | 29911 | 39544 | -0.5432 | 0.0000 | |
| GSE63941 | HOOK2 | 29911 | 218780_at | 1.5756 | 0.0000 | |
| GSE77861 | HOOK2 | 29911 | 218780_at | 0.0999 | 0.7132 | |
| GSE97050 | HOOK2 | 29911 | A_23_P153441 | 0.0258 | 0.9304 | |
| SRP007169 | HOOK2 | 29911 | RNAseq | -0.3833 | 0.5383 | |
| SRP064894 | HOOK2 | 29911 | RNAseq | 0.2396 | 0.4264 | |
| SRP133303 | HOOK2 | 29911 | RNAseq | -0.6872 | 0.0009 | |
| SRP159526 | HOOK2 | 29911 | RNAseq | -0.1713 | 0.6283 | |
| SRP193095 | HOOK2 | 29911 | RNAseq | -0.3522 | 0.0347 | |
| SRP219564 | HOOK2 | 29911 | RNAseq | 0.1938 | 0.7259 | |
| TCGA | HOOK2 | 29911 | RNAseq | 0.0199 | 0.7601 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HOOK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HOOK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HOOK2 | 29911 | 4 | 2 | 24 | |
| GSE20123 | HOOK2 | 29911 | 3 | 1 | 26 | |
| GSE43470 | HOOK2 | 29911 | 2 | 6 | 35 | |
| GSE46452 | HOOK2 | 29911 | 47 | 1 | 11 | |
| GSE47630 | HOOK2 | 29911 | 4 | 7 | 29 | |
| GSE54993 | HOOK2 | 29911 | 16 | 3 | 51 | |
| GSE54994 | HOOK2 | 29911 | 6 | 13 | 34 | |
| GSE60625 | HOOK2 | 29911 | 9 | 0 | 2 | |
| GSE74703 | HOOK2 | 29911 | 2 | 4 | 30 | |
| GSE74704 | HOOK2 | 29911 | 0 | 1 | 19 | |
| TCGA | HOOK2 | 29911 | 16 | 13 | 67 |
Total number of gains: 109; Total number of losses: 51; Total Number of normals: 328.
Somatic mutations of HOOK2:
Generating mutation plots.
Highly correlated genes for HOOK2:
Showing top 20/420 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HOOK2 | MARVELD2 | 0.790358 | 4 | 0 | 4 |
| HOOK2 | MAL2 | 0.741039 | 6 | 0 | 6 |
| HOOK2 | VAV3 | 0.728787 | 3 | 0 | 3 |
| HOOK2 | ZNF57 | 0.72576 | 4 | 0 | 4 |
| HOOK2 | PET100 | 0.699386 | 3 | 0 | 3 |
| HOOK2 | SYTL1 | 0.699277 | 7 | 0 | 6 |
| HOOK2 | TSTD1 | 0.697881 | 5 | 0 | 5 |
| HOOK2 | GJB3 | 0.662543 | 4 | 0 | 4 |
| HOOK2 | FBXL16 | 0.660184 | 4 | 0 | 3 |
| HOOK2 | TPD52L1 | 0.65814 | 6 | 0 | 5 |
| HOOK2 | ATG4D | 0.654753 | 5 | 0 | 4 |
| HOOK2 | PADI1 | 0.64754 | 3 | 0 | 3 |
| HOOK2 | FRMD4B | 0.646738 | 5 | 0 | 5 |
| HOOK2 | ELOVL1 | 0.644492 | 3 | 0 | 3 |
| HOOK2 | MAP7 | 0.643472 | 8 | 0 | 5 |
| HOOK2 | HDHD3 | 0.641887 | 6 | 0 | 6 |
| HOOK2 | ARPC3 | 0.641755 | 5 | 0 | 4 |
| HOOK2 | KCNK1 | 0.638364 | 4 | 0 | 3 |
| HOOK2 | TMEM79 | 0.638104 | 6 | 0 | 4 |
| HOOK2 | PROM2 | 0.637568 | 6 | 0 | 4 |
For details and further investigation, click here
