BAX

 

Full name: BCL2 associated X, apoptosis regulator Alias Symbol: BCL2L4
Type: protein-coding gene Cytoband: 19q13.33
Entrez ID: 581 HGNC ID: HGNC:959 Ensembl Gene: ENSG00000087088 OMIM ID: 600040
Drug and gene relationship at DGIdb

 

BAX involved pathways:

KEGG pathway Description View
hsa04071Sphingolipid signaling pathway
hsa04115p53 signaling pathway
hsa04210Apoptosis
hsa04211Longevity regulating pathway - mammal
hsa04722Neurotrophin signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05020Prion diseases
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05210Colorectal cancer

 

Expression of BAX:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BAX 581 211833_s_at 0.5236 0.0545
GSE20347 BAX 581 211833_s_at 0.0546 0.7789
GSE23400 BAX 581 211833_s_at 0.5652 0.0000
GSE26886 BAX 581 211833_s_at -0.1210 0.4783
GSE29001 BAX 581 211833_s_at 0.5309 0.2551
GSE38129 BAX 581 211833_s_at 0.4852 0.1120
GSE45670 BAX 581 211833_s_at 0.5212 0.0005
GSE53622 BAX 581 4054 -0.0341 0.6711
GSE53624 BAX 581 4054 0.2039 0.0048
GSE63941 BAX 581 211833_s_at -0.7296 0.0930
GSE77861 BAX 581 208478_s_at 0.4843 0.0587
GSE97050 BAX 581 A_23_P208706 0.2826 0.2776
SRP007169 BAX 581 RNAseq 0.3636 0.2678
SRP008496 BAX 581 RNAseq 0.2175 0.2946
SRP064894 BAX 581 RNAseq 1.2937 0.0000
SRP133303 BAX 581 RNAseq 0.4221 0.0156
SRP159526 BAX 581 RNAseq 0.6560 0.0006
SRP193095 BAX 581 RNAseq 0.2473 0.0440
SRP219564 BAX 581 RNAseq 0.4082 0.3992
TCGA BAX 581 RNAseq 0.3648 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by BAX expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BAX:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BAX 581 4 4 22
GSE20123 BAX 581 4 3 23
GSE43470 BAX 581 4 10 29
GSE46452 BAX 581 45 1 13
GSE47630 BAX 581 9 6 25
GSE54993 BAX 581 17 4 49
GSE54994 BAX 581 4 14 35
GSE60625 BAX 581 9 0 2
GSE74703 BAX 581 4 7 25
GSE74704 BAX 581 4 1 15
TCGA BAX 581 14 18 64

Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.  

 

Somatic mutations of BAX:

 

Generating mutation plots.

 

Highly correlated genes for BAX:

 

Showing top 20/273 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BAXPOC1A0.803111303
BAXCECR20.789332303
BAXC4orf460.759275303
BAXFUT10.73435404
BAXTKTL10.73192303
BAXTXNDC120.728073303
BAXATG4D0.716125303
BAXCMSS10.715475303
BAXMEX3D0.713661605
BAXTRAIP0.712517404
BAXUBE2S0.710062808
BAXCHP20.709254303
BAXMTERF30.708019303
BAXRASGRF20.707226303
BAXTRIM110.705042403
BAXRAD54B0.702937504
BAXYEATS20.697884404
BAXZNF6870.695845303
BAXWDR460.695034706
BAXTMCC20.694607403

For details and further investigation, click here