| Full name: autophagy related 5 | Alias Symbol: ASP|APG5|hAPG5 | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 9474 | HGNC ID: HGNC:589 | Ensembl Gene: ENSG00000057663 | OMIM ID: 604261 |
| Drug and gene relationship at DGIdb | |||
ATG5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04211 | Longevity regulating pathway - mammal | |
| hsa04213 | Longevity regulating pathway - multiple species | |
| hsa04622 | RIG-I-like receptor signaling pathway |
Expression of ATG5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATG5 | 9474 | 202511_s_at | -0.0503 | 0.8833 | |
| GSE20347 | ATG5 | 9474 | 202511_s_at | 0.2017 | 0.2371 | |
| GSE23400 | ATG5 | 9474 | 202511_s_at | 0.3750 | 0.0000 | |
| GSE26886 | ATG5 | 9474 | 202511_s_at | 0.3934 | 0.0268 | |
| GSE29001 | ATG5 | 9474 | 202512_s_at | 0.1480 | 0.6515 | |
| GSE38129 | ATG5 | 9474 | 202511_s_at | 0.4226 | 0.0008 | |
| GSE45670 | ATG5 | 9474 | 202511_s_at | 0.4362 | 0.0000 | |
| GSE53622 | ATG5 | 9474 | 116881 | 0.1169 | 0.1304 | |
| GSE53624 | ATG5 | 9474 | 116881 | 0.3153 | 0.0000 | |
| GSE63941 | ATG5 | 9474 | 202511_s_at | 0.8742 | 0.0037 | |
| GSE77861 | ATG5 | 9474 | 202511_s_at | 0.2052 | 0.5028 | |
| GSE97050 | ATG5 | 9474 | A_24_P175059 | -0.2262 | 0.4146 | |
| SRP007169 | ATG5 | 9474 | RNAseq | -0.0688 | 0.8222 | |
| SRP008496 | ATG5 | 9474 | RNAseq | -0.0159 | 0.9448 | |
| SRP064894 | ATG5 | 9474 | RNAseq | 0.1184 | 0.3764 | |
| SRP133303 | ATG5 | 9474 | RNAseq | 0.4660 | 0.0007 | |
| SRP159526 | ATG5 | 9474 | RNAseq | 0.0818 | 0.7109 | |
| SRP193095 | ATG5 | 9474 | RNAseq | -0.1809 | 0.1164 | |
| SRP219564 | ATG5 | 9474 | RNAseq | -0.0407 | 0.8858 | |
| TCGA | ATG5 | 9474 | RNAseq | 0.0063 | 0.8992 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATG5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATG5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATG5 | 9474 | 3 | 3 | 24 | |
| GSE20123 | ATG5 | 9474 | 3 | 2 | 25 | |
| GSE43470 | ATG5 | 9474 | 3 | 1 | 39 | |
| GSE46452 | ATG5 | 9474 | 2 | 11 | 46 | |
| GSE47630 | ATG5 | 9474 | 9 | 4 | 27 | |
| GSE54993 | ATG5 | 9474 | 3 | 2 | 65 | |
| GSE54994 | ATG5 | 9474 | 8 | 8 | 37 | |
| GSE60625 | ATG5 | 9474 | 0 | 2 | 9 | |
| GSE74703 | ATG5 | 9474 | 2 | 1 | 33 | |
| GSE74704 | ATG5 | 9474 | 1 | 0 | 19 | |
| TCGA | ATG5 | 9474 | 5 | 24 | 67 |
Total number of gains: 39; Total number of losses: 58; Total Number of normals: 391.
Somatic mutations of ATG5:
Generating mutation plots.
Highly correlated genes for ATG5:
Showing top 20/498 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATG5 | SORL1 | 0.676319 | 4 | 0 | 4 |
| ATG5 | RTN4IP1 | 0.654548 | 7 | 0 | 6 |
| ATG5 | WDR41 | 0.645788 | 4 | 0 | 3 |
| ATG5 | NCAPH | 0.643457 | 4 | 0 | 4 |
| ATG5 | RPL7L1 | 0.640624 | 4 | 0 | 4 |
| ATG5 | MRPL42 | 0.636803 | 9 | 0 | 8 |
| ATG5 | PARG | 0.634336 | 4 | 0 | 4 |
| ATG5 | NOL10 | 0.632821 | 4 | 0 | 4 |
| ATG5 | PRKRA | 0.632639 | 5 | 0 | 3 |
| ATG5 | B4GALNT3 | 0.63199 | 3 | 0 | 3 |
| ATG5 | SPPL2A | 0.629746 | 5 | 0 | 5 |
| ATG5 | KCNE3 | 0.628834 | 3 | 0 | 3 |
| ATG5 | PSMC2 | 0.628415 | 6 | 0 | 5 |
| ATG5 | ZNF638 | 0.627283 | 3 | 0 | 3 |
| ATG5 | TMEM167A | 0.626244 | 4 | 0 | 3 |
| ATG5 | CSNK2A2 | 0.624784 | 4 | 0 | 3 |
| ATG5 | FAM83B | 0.623323 | 4 | 0 | 3 |
| ATG5 | CETN3 | 0.620432 | 3 | 0 | 3 |
| ATG5 | IAH1 | 0.61709 | 4 | 0 | 4 |
| ATG5 | ZNF689 | 0.615511 | 3 | 0 | 3 |
For details and further investigation, click here
