ATM

 

Full name: ATM serine/threonine kinase Alias Symbol: TEL1|TELO1
Type: protein-coding gene Cytoband: 11q22.3
Entrez ID: 472 HGNC ID: HGNC:795 Ensembl Gene: ENSG00000149311 OMIM ID: 607585
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 4/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ATM involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04210Apoptosis
hsa05166HTLV-I infection

 

Expression of ATM:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ATM 472 212672_at -0.0210 0.9755
GSE20347 ATM 472 210858_x_at 0.2172 0.2343
GSE23400 ATM 472 210858_x_at 0.3304 0.0004
GSE26886 ATM 472 210858_x_at 0.5904 0.1225
GSE29001 ATM 472 210858_x_at 0.3607 0.1447
GSE38129 ATM 472 210858_x_at 0.0890 0.7953
GSE45670 ATM 472 210858_x_at -0.0966 0.6564
GSE53622 ATM 472 134064 -0.0167 0.8601
GSE53624 ATM 472 134064 0.0757 0.3290
GSE63941 ATM 472 210858_x_at -0.0219 0.9628
GSE77861 ATM 472 212672_at 0.4707 0.0569
GSE97050 ATM 472 A_33_P3589722 0.1386 0.7776
SRP007169 ATM 472 RNAseq 1.2982 0.0043
SRP008496 ATM 472 RNAseq 1.5588 0.0000
SRP064894 ATM 472 RNAseq 0.1811 0.4326
SRP133303 ATM 472 RNAseq -0.2039 0.1972
SRP159526 ATM 472 RNAseq -0.4430 0.0584
SRP193095 ATM 472 RNAseq 0.0036 0.9837
SRP219564 ATM 472 RNAseq 0.1635 0.5951
TCGA ATM 472 RNAseq -0.1769 0.0069

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by ATM expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ATM:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ATM 472 0 13 17
GSE20123 ATM 472 0 13 17
GSE43470 ATM 472 2 6 35
GSE46452 ATM 472 3 26 30
GSE47630 ATM 472 2 19 19
GSE54993 ATM 472 9 1 60
GSE54994 ATM 472 5 19 29
GSE60625 ATM 472 0 3 8
GSE74703 ATM 472 1 4 31
GSE74704 ATM 472 0 9 11
TCGA ATM 472 6 48 42

Total number of gains: 28; Total number of losses: 161; Total Number of normals: 299.  

 

Somatic mutations of ATM:

 

Generating mutation plots.

 

Highly correlated genes for ATM:

 

Showing top 20/359 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ATMQSOX20.782099303
ATMWDR750.760643303
ATMEMG10.759077303
ATMMETAP1D0.746284303
ATMLRP40.744877303
ATMNUP2050.740076303
ATMMIS120.738114303
ATMTMEM600.734985303
ATMCDCA30.733292303
ATMAMMECR1L0.729798303
ATMZNF3840.726428303
ATMFAM76B0.718192403
ATMCERS50.714093303
ATMCCNB20.712254404
ATMSLC30A60.712239303
ATMBORA0.71055303
ATMUBE2C0.703787303
ATMSMAD30.70002303
ATMVMA210.699258303
ATMWDR50.69666303

For details and further investigation, click here