| Full name: WD repeat domain 5 | Alias Symbol: SWD3|CFAP89 | ||
| Type: protein-coding gene | Cytoband: 9q34.2 | ||
| Entrez ID: 11091 | HGNC ID: HGNC:12757 | Ensembl Gene: ENSG00000196363 | OMIM ID: 609012 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WDR5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR5 | 11091 | 225170_at | 1.1057 | 0.0122 | |
| GSE26886 | WDR5 | 11091 | 223308_s_at | 0.4253 | 0.0090 | |
| GSE45670 | WDR5 | 11091 | 225170_at | 0.4208 | 0.0124 | |
| GSE53622 | WDR5 | 11091 | 24432 | 0.3802 | 0.0000 | |
| GSE53624 | WDR5 | 11091 | 24432 | 0.8004 | 0.0000 | |
| GSE63941 | WDR5 | 11091 | 223308_s_at | 1.5979 | 0.0003 | |
| GSE77861 | WDR5 | 11091 | 225170_at | 0.5488 | 0.0066 | |
| GSE97050 | WDR5 | 11091 | A_33_P3292417 | -0.0153 | 0.9469 | |
| SRP007169 | WDR5 | 11091 | RNAseq | 1.1801 | 0.0107 | |
| SRP008496 | WDR5 | 11091 | RNAseq | 1.0121 | 0.0005 | |
| SRP064894 | WDR5 | 11091 | RNAseq | 0.7957 | 0.0008 | |
| SRP133303 | WDR5 | 11091 | RNAseq | 0.4872 | 0.0032 | |
| SRP159526 | WDR5 | 11091 | RNAseq | 0.8353 | 0.0000 | |
| SRP193095 | WDR5 | 11091 | RNAseq | 0.4879 | 0.0000 | |
| SRP219564 | WDR5 | 11091 | RNAseq | 0.4415 | 0.3092 | |
| TCGA | WDR5 | 11091 | RNAseq | 0.1739 | 0.0016 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by WDR5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR5 | 11091 | 4 | 7 | 19 | |
| GSE20123 | WDR5 | 11091 | 4 | 7 | 19 | |
| GSE43470 | WDR5 | 11091 | 4 | 7 | 32 | |
| GSE46452 | WDR5 | 11091 | 6 | 13 | 40 | |
| GSE47630 | WDR5 | 11091 | 6 | 15 | 19 | |
| GSE54993 | WDR5 | 11091 | 3 | 3 | 64 | |
| GSE54994 | WDR5 | 11091 | 12 | 9 | 32 | |
| GSE60625 | WDR5 | 11091 | 0 | 0 | 11 | |
| GSE74703 | WDR5 | 11091 | 4 | 5 | 27 | |
| GSE74704 | WDR5 | 11091 | 2 | 5 | 13 | |
| TCGA | WDR5 | 11091 | 29 | 25 | 42 |
Total number of gains: 74; Total number of losses: 96; Total Number of normals: 318.
Somatic mutations of WDR5:
Generating mutation plots.
Highly correlated genes for WDR5:
Showing top 20/1536 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR5 | RNF4 | 0.820733 | 3 | 0 | 3 |
| WDR5 | HNRNPAB | 0.814322 | 3 | 0 | 3 |
| WDR5 | POLR2K | 0.813562 | 3 | 0 | 3 |
| WDR5 | FZD6 | 0.803801 | 4 | 0 | 3 |
| WDR5 | CCDC127 | 0.802324 | 3 | 0 | 3 |
| WDR5 | ASNSD1 | 0.799726 | 3 | 0 | 3 |
| WDR5 | RBM17 | 0.789247 | 3 | 0 | 3 |
| WDR5 | RNMT | 0.786895 | 3 | 0 | 3 |
| WDR5 | CCS | 0.785857 | 3 | 0 | 3 |
| WDR5 | GNPNAT1 | 0.778418 | 3 | 0 | 3 |
| WDR5 | SMAD1 | 0.778092 | 3 | 0 | 3 |
| WDR5 | RAD1 | 0.774619 | 4 | 0 | 4 |
| WDR5 | INSR | 0.772819 | 3 | 0 | 3 |
| WDR5 | DSCC1 | 0.771796 | 5 | 0 | 5 |
| WDR5 | NCOA6 | 0.766296 | 3 | 0 | 3 |
| WDR5 | NAPEPLD | 0.764152 | 4 | 0 | 3 |
| WDR5 | ZBED1 | 0.764081 | 3 | 0 | 3 |
| WDR5 | UBAP2L | 0.764078 | 4 | 0 | 3 |
| WDR5 | KLHDC3 | 0.761966 | 3 | 0 | 3 |
| WDR5 | TERF2 | 0.745552 | 3 | 0 | 3 |
For details and further investigation, click here
