| Full name: LDL receptor related protein 4 | Alias Symbol: MEGF7|CLSS|LRP-4|SOST2 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 4038 | HGNC ID: HGNC:6696 | Ensembl Gene: ENSG00000134569 | OMIM ID: 604270 |
| Drug and gene relationship at DGIdb | |||
Expression of LRP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRP4 | 4038 | 212850_s_at | 0.2083 | 0.6526 | |
| GSE20347 | LRP4 | 4038 | 212850_s_at | 0.9349 | 0.0052 | |
| GSE23400 | LRP4 | 4038 | 212850_s_at | 0.1990 | 0.0020 | |
| GSE26886 | LRP4 | 4038 | 212850_s_at | 1.7023 | 0.0001 | |
| GSE29001 | LRP4 | 4038 | 212850_s_at | -0.0135 | 0.9795 | |
| GSE38129 | LRP4 | 4038 | 212850_s_at | 0.8851 | 0.0006 | |
| GSE45670 | LRP4 | 4038 | 212850_s_at | -0.0338 | 0.9281 | |
| GSE53622 | LRP4 | 4038 | 16192 | 0.3643 | 0.0248 | |
| GSE53624 | LRP4 | 4038 | 16192 | 0.3898 | 0.0017 | |
| GSE63941 | LRP4 | 4038 | 212850_s_at | 0.0382 | 0.9673 | |
| GSE77861 | LRP4 | 4038 | 212850_s_at | 0.2147 | 0.3096 | |
| GSE97050 | LRP4 | 4038 | A_24_P403561 | -0.0749 | 0.7696 | |
| SRP007169 | LRP4 | 4038 | RNAseq | 0.8657 | 0.2144 | |
| SRP008496 | LRP4 | 4038 | RNAseq | 1.3122 | 0.0056 | |
| SRP064894 | LRP4 | 4038 | RNAseq | -0.3213 | 0.3272 | |
| SRP133303 | LRP4 | 4038 | RNAseq | 0.0571 | 0.8732 | |
| SRP159526 | LRP4 | 4038 | RNAseq | 0.8380 | 0.2248 | |
| SRP193095 | LRP4 | 4038 | RNAseq | 0.0062 | 0.9741 | |
| SRP219564 | LRP4 | 4038 | RNAseq | 0.1984 | 0.7992 | |
| TCGA | LRP4 | 4038 | RNAseq | -0.0777 | 0.5250 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LRP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRP4 | 4038 | 3 | 7 | 20 | |
| GSE20123 | LRP4 | 4038 | 3 | 6 | 21 | |
| GSE43470 | LRP4 | 4038 | 2 | 4 | 37 | |
| GSE46452 | LRP4 | 4038 | 8 | 5 | 46 | |
| GSE47630 | LRP4 | 4038 | 3 | 9 | 28 | |
| GSE54993 | LRP4 | 4038 | 3 | 1 | 66 | |
| GSE54994 | LRP4 | 4038 | 1 | 10 | 42 | |
| GSE60625 | LRP4 | 4038 | 0 | 0 | 11 | |
| GSE74703 | LRP4 | 4038 | 2 | 2 | 32 | |
| GSE74704 | LRP4 | 4038 | 2 | 4 | 14 | |
| TCGA | LRP4 | 4038 | 11 | 19 | 66 |
Total number of gains: 38; Total number of losses: 67; Total Number of normals: 383.
Somatic mutations of LRP4:
Generating mutation plots.
Highly correlated genes for LRP4:
Showing top 20/483 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRP4 | THEM4 | 0.7993 | 3 | 0 | 3 |
| LRP4 | SH3RF3 | 0.78809 | 3 | 0 | 3 |
| LRP4 | C1orf131 | 0.761142 | 3 | 0 | 3 |
| LRP4 | PTPN2 | 0.758724 | 3 | 0 | 3 |
| LRP4 | ZNF827 | 0.757485 | 3 | 0 | 3 |
| LRP4 | CDC42SE2 | 0.75121 | 3 | 0 | 3 |
| LRP4 | PTPN4 | 0.748584 | 3 | 0 | 3 |
| LRP4 | DLG5 | 0.747765 | 3 | 0 | 3 |
| LRP4 | ATM | 0.744877 | 3 | 0 | 3 |
| LRP4 | FAM49A | 0.736691 | 3 | 0 | 3 |
| LRP4 | ACBD6 | 0.73309 | 3 | 0 | 3 |
| LRP4 | METTL23 | 0.731428 | 3 | 0 | 3 |
| LRP4 | ATP11C | 0.729523 | 3 | 0 | 3 |
| LRP4 | WDR81 | 0.725624 | 3 | 0 | 3 |
| LRP4 | WDR75 | 0.721562 | 3 | 0 | 3 |
| LRP4 | FTSJ3 | 0.719368 | 4 | 0 | 4 |
| LRP4 | TBC1D2B | 0.719069 | 3 | 0 | 3 |
| LRP4 | IFT20 | 0.715553 | 4 | 0 | 3 |
| LRP4 | RPL7L1 | 0.714999 | 3 | 0 | 3 |
| LRP4 | MEGF6 | 0.714349 | 3 | 0 | 3 |
For details and further investigation, click here
