SMAD3

 

Full name: SMAD family member 3 Alias Symbol: JV15-2|HsT17436
Type: protein-coding gene Cytoband: 15q22.33
Entrez ID: 4088 HGNC ID: HGNC:6769 Ensembl Gene: ENSG00000166949 OMIM ID: 603109
Drug and gene relationship at DGIdb

 

SMAD3 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
hsa04520Adherens junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05142Chagas disease (American trypanosomiasis)
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
hsa05321Inflammatory bowel disease (IBD)

 

Expression of SMAD3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SMAD3 4088 218284_at 0.0098 0.9948
GSE20347 SMAD3 4088 218284_at 0.1369 0.6311
GSE23400 SMAD3 4088 218284_at 0.2938 0.0100
GSE26886 SMAD3 4088 218284_at 0.2572 0.1754
GSE29001 SMAD3 4088 218284_at 0.2503 0.3903
GSE38129 SMAD3 4088 218284_at 0.2548 0.2600
GSE45670 SMAD3 4088 218284_at 0.0146 0.9563
GSE53622 SMAD3 4088 90933 0.2289 0.0146
GSE53624 SMAD3 4088 90933 0.1205 0.0851
GSE63941 SMAD3 4088 218284_at -2.0512 0.0122
GSE77861 SMAD3 4088 218284_at 0.4159 0.1776
GSE97050 SMAD3 4088 A_23_P48936 -0.1694 0.5217
SRP007169 SMAD3 4088 RNAseq 0.2025 0.6398
SRP008496 SMAD3 4088 RNAseq 0.1841 0.6061
SRP064894 SMAD3 4088 RNAseq -0.2484 0.3163
SRP133303 SMAD3 4088 RNAseq -0.0113 0.9577
SRP159526 SMAD3 4088 RNAseq -0.0650 0.8927
SRP193095 SMAD3 4088 RNAseq 0.4628 0.0030
SRP219564 SMAD3 4088 RNAseq -0.3648 0.3824
TCGA SMAD3 4088 RNAseq 0.1601 0.0168

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by SMAD3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SMAD3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SMAD3 4088 8 3 19
GSE20123 SMAD3 4088 8 3 19
GSE43470 SMAD3 4088 4 6 33
GSE46452 SMAD3 4088 3 7 49
GSE47630 SMAD3 4088 8 10 22
GSE54993 SMAD3 4088 5 6 59
GSE54994 SMAD3 4088 6 7 40
GSE60625 SMAD3 4088 4 0 7
GSE74703 SMAD3 4088 4 3 29
GSE74704 SMAD3 4088 3 3 14
TCGA SMAD3 4088 10 15 71

Total number of gains: 63; Total number of losses: 63; Total Number of normals: 362.  

 

Somatic mutations of SMAD3:

 

Generating mutation plots.

 

Highly correlated genes for SMAD3:

 

Showing top 20/175 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SMAD3TMEM600.805889303
SMAD3CAPN20.794805303
SMAD3ANKS60.782844303
SMAD3CLDN120.774695303
SMAD3WDR770.763515303
SMAD3RNF260.762556303
SMAD3WDFY10.755767303
SMAD3DLG30.753192303
SMAD3ARHGAP170.741717303
SMAD3LARP40.72686303
SMAD3ANKRD500.720543303
SMAD3C2CD20.718631303
SMAD3SRGAP30.718013303
SMAD3TTC270.716514303
SMAD3MVP0.716027303
SMAD3HIVEP10.713539303
SMAD3FAM114A10.71346303
SMAD3TRAF70.711598303
SMAD3ASH2L0.711308303
SMAD3PHKG20.710763303

For details and further investigation, click here