| Full name: ubiquitin conjugating enzyme E2 C | Alias Symbol: UBCH10 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 11065 | HGNC ID: HGNC:15937 | Ensembl Gene: ENSG00000175063 | OMIM ID: 605574 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBE2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE2C | 11065 | 202954_at | 2.0320 | 0.0054 | |
| GSE20347 | UBE2C | 11065 | 202954_at | 1.7213 | 0.0000 | |
| GSE23400 | UBE2C | 11065 | 202954_at | 1.4622 | 0.0000 | |
| GSE26886 | UBE2C | 11065 | 202954_at | 0.9505 | 0.0037 | |
| GSE29001 | UBE2C | 11065 | 202954_at | 1.7569 | 0.0001 | |
| GSE38129 | UBE2C | 11065 | 202954_at | 2.2530 | 0.0000 | |
| GSE45670 | UBE2C | 11065 | 202954_at | 1.7832 | 0.0000 | |
| GSE53622 | UBE2C | 11065 | 16011 | 2.0622 | 0.0000 | |
| GSE53624 | UBE2C | 11065 | 16011 | 2.3047 | 0.0000 | |
| GSE63941 | UBE2C | 11065 | 202954_at | 3.9447 | 0.0000 | |
| GSE77861 | UBE2C | 11065 | 202954_at | 1.1442 | 0.0055 | |
| GSE97050 | UBE2C | 11065 | A_24_P297539 | 1.7451 | 0.0981 | |
| SRP007169 | UBE2C | 11065 | RNAseq | 2.0688 | 0.0000 | |
| SRP008496 | UBE2C | 11065 | RNAseq | 1.8633 | 0.0000 | |
| SRP064894 | UBE2C | 11065 | RNAseq | 2.7071 | 0.0000 | |
| SRP133303 | UBE2C | 11065 | RNAseq | 2.1746 | 0.0000 | |
| SRP159526 | UBE2C | 11065 | RNAseq | 2.1205 | 0.0000 | |
| SRP193095 | UBE2C | 11065 | RNAseq | 1.4106 | 0.0000 | |
| SRP219564 | UBE2C | 11065 | RNAseq | 2.1114 | 0.0081 | |
| TCGA | UBE2C | 11065 | RNAseq | 1.3390 | 0.0000 |
Upregulated datasets: 18; Downregulated datasets: 0.
Survival by UBE2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBE2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE2C | 11065 | 14 | 1 | 15 | |
| GSE20123 | UBE2C | 11065 | 14 | 1 | 15 | |
| GSE43470 | UBE2C | 11065 | 12 | 1 | 30 | |
| GSE46452 | UBE2C | 11065 | 29 | 0 | 30 | |
| GSE47630 | UBE2C | 11065 | 24 | 1 | 15 | |
| GSE54993 | UBE2C | 11065 | 0 | 18 | 52 | |
| GSE54994 | UBE2C | 11065 | 25 | 0 | 28 | |
| GSE60625 | UBE2C | 11065 | 0 | 0 | 11 | |
| GSE74703 | UBE2C | 11065 | 10 | 1 | 25 | |
| GSE74704 | UBE2C | 11065 | 10 | 0 | 10 | |
| TCGA | UBE2C | 11065 | 46 | 3 | 47 |
Total number of gains: 184; Total number of losses: 26; Total Number of normals: 278.
Somatic mutations of UBE2C:
Generating mutation plots.
Highly correlated genes for UBE2C:
Showing top 20/2267 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE2C | TPX2 | 0.896949 | 13 | 0 | 13 |
| UBE2C | AURKA | 0.892002 | 13 | 0 | 13 |
| UBE2C | MYBL2 | 0.878238 | 12 | 0 | 12 |
| UBE2C | CCNB2 | 0.877561 | 12 | 0 | 12 |
| UBE2C | TOP2A | 0.876429 | 13 | 0 | 13 |
| UBE2C | AURKB | 0.875198 | 13 | 0 | 13 |
| UBE2C | CDKN3 | 0.863959 | 13 | 0 | 13 |
| UBE2C | NEK2 | 0.859309 | 13 | 0 | 13 |
| UBE2C | CDC20 | 0.858888 | 12 | 0 | 12 |
| UBE2C | GINS1 | 0.85155 | 12 | 0 | 12 |
| UBE2C | NCAPH | 0.847465 | 9 | 0 | 9 |
| UBE2C | KIF20A | 0.845784 | 13 | 0 | 13 |
| UBE2C | MCM2 | 0.845594 | 12 | 0 | 12 |
| UBE2C | BUB1 | 0.844611 | 11 | 0 | 11 |
| UBE2C | CDCA3 | 0.843566 | 13 | 0 | 13 |
| UBE2C | CEP55 | 0.842311 | 13 | 0 | 13 |
| UBE2C | BIRC5 | 0.839277 | 12 | 0 | 12 |
| UBE2C | NUF2 | 0.837515 | 9 | 0 | 8 |
| UBE2C | TRIP13 | 0.836675 | 13 | 0 | 12 |
| UBE2C | CENPF | 0.835828 | 13 | 0 | 12 |
For details and further investigation, click here
