| Full name: ataxin 10 | Alias Symbol: E46L|FLJ37990 | ||
| Type: protein-coding gene | Cytoband: 22q13.31 | ||
| Entrez ID: 25814 | HGNC ID: HGNC:10549 | Ensembl Gene: ENSG00000130638 | OMIM ID: 611150 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ATXN10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATXN10 | 25814 | 208833_s_at | -0.2098 | 0.5209 | |
| GSE20347 | ATXN10 | 25814 | 208833_s_at | -0.0723 | 0.7342 | |
| GSE23400 | ATXN10 | 25814 | 208833_s_at | 0.2687 | 0.0000 | |
| GSE26886 | ATXN10 | 25814 | 208833_s_at | 0.1700 | 0.3638 | |
| GSE29001 | ATXN10 | 25814 | 208833_s_at | 0.1190 | 0.6292 | |
| GSE38129 | ATXN10 | 25814 | 208833_s_at | 0.1516 | 0.2339 | |
| GSE45670 | ATXN10 | 25814 | 208833_s_at | 0.0933 | 0.5792 | |
| GSE53622 | ATXN10 | 25814 | 25327 | 0.2441 | 0.0000 | |
| GSE53624 | ATXN10 | 25814 | 25327 | 0.0144 | 0.8935 | |
| GSE63941 | ATXN10 | 25814 | 208833_s_at | -0.3914 | 0.4115 | |
| GSE77861 | ATXN10 | 25814 | 208833_s_at | 0.1947 | 0.5118 | |
| GSE97050 | ATXN10 | 25814 | A_24_P391368 | 0.0477 | 0.8520 | |
| SRP007169 | ATXN10 | 25814 | RNAseq | -0.4007 | 0.1823 | |
| SRP008496 | ATXN10 | 25814 | RNAseq | -0.2136 | 0.2024 | |
| SRP064894 | ATXN10 | 25814 | RNAseq | 0.1400 | 0.3466 | |
| SRP133303 | ATXN10 | 25814 | RNAseq | 0.0767 | 0.5493 | |
| SRP159526 | ATXN10 | 25814 | RNAseq | 0.3859 | 0.0179 | |
| SRP193095 | ATXN10 | 25814 | RNAseq | -0.1782 | 0.1733 | |
| SRP219564 | ATXN10 | 25814 | RNAseq | 0.2100 | 0.5636 | |
| TCGA | ATXN10 | 25814 | RNAseq | 0.1329 | 0.0047 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATXN10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATXN10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATXN10 | 25814 | 5 | 6 | 19 | |
| GSE20123 | ATXN10 | 25814 | 4 | 5 | 21 | |
| GSE43470 | ATXN10 | 25814 | 2 | 6 | 35 | |
| GSE46452 | ATXN10 | 25814 | 31 | 2 | 26 | |
| GSE47630 | ATXN10 | 25814 | 9 | 4 | 27 | |
| GSE54993 | ATXN10 | 25814 | 3 | 6 | 61 | |
| GSE54994 | ATXN10 | 25814 | 11 | 7 | 35 | |
| GSE60625 | ATXN10 | 25814 | 5 | 0 | 6 | |
| GSE74703 | ATXN10 | 25814 | 2 | 4 | 30 | |
| GSE74704 | ATXN10 | 25814 | 2 | 3 | 15 | |
| TCGA | ATXN10 | 25814 | 27 | 15 | 54 |
Total number of gains: 101; Total number of losses: 58; Total Number of normals: 329.
Somatic mutations of ATXN10:
Generating mutation plots.
Highly correlated genes for ATXN10:
Showing top 20/284 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATXN10 | RTN4IP1 | 0.740925 | 3 | 0 | 3 |
| ATXN10 | HIPK1 | 0.733922 | 3 | 0 | 3 |
| ATXN10 | SREBF2 | 0.716208 | 3 | 0 | 3 |
| ATXN10 | RAP1B | 0.707798 | 3 | 0 | 3 |
| ATXN10 | MAML2 | 0.703753 | 3 | 0 | 3 |
| ATXN10 | RPS23 | 0.702728 | 3 | 0 | 3 |
| ATXN10 | ZNF10 | 0.70054 | 3 | 0 | 3 |
| ATXN10 | ZNF655 | 0.696231 | 3 | 0 | 3 |
| ATXN10 | FEZ2 | 0.687389 | 3 | 0 | 3 |
| ATXN10 | LRIG3 | 0.686249 | 3 | 0 | 3 |
| ATXN10 | XPNPEP1 | 0.685109 | 3 | 0 | 3 |
| ATXN10 | PHF6 | 0.672491 | 3 | 0 | 3 |
| ATXN10 | SWAP70 | 0.66905 | 4 | 0 | 3 |
| ATXN10 | PTPMT1 | 0.66848 | 4 | 0 | 3 |
| ATXN10 | WDR61 | 0.661203 | 7 | 0 | 5 |
| ATXN10 | PSMD7 | 0.659084 | 7 | 0 | 6 |
| ATXN10 | CDC40 | 0.658506 | 7 | 0 | 7 |
| ATXN10 | ZNF595 | 0.658146 | 3 | 0 | 3 |
| ATXN10 | ARF4 | 0.657969 | 3 | 0 | 3 |
| ATXN10 | PSMD8 | 0.655898 | 5 | 0 | 4 |
For details and further investigation, click here
