| Full name: proteasome 26S subunit, non-ATPase 8 | Alias Symbol: S14|Nin1p|p31|HIP6|HYPF|Rpn12 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 5714 | HGNC ID: HGNC:9566 | Ensembl Gene: ENSG00000099341 | OMIM ID: 617844 |
| Drug and gene relationship at DGIdb | |||
Expression of PSMD8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMD8 | 5714 | 200820_at | -0.1575 | 0.5458 | |
| GSE20347 | PSMD8 | 5714 | 200820_at | -0.1465 | 0.3684 | |
| GSE23400 | PSMD8 | 5714 | 200820_at | 0.0778 | 0.3332 | |
| GSE26886 | PSMD8 | 5714 | 200820_at | -0.5336 | 0.0028 | |
| GSE29001 | PSMD8 | 5714 | 200820_at | -0.3194 | 0.3547 | |
| GSE38129 | PSMD8 | 5714 | 200820_at | 0.1398 | 0.3166 | |
| GSE45670 | PSMD8 | 5714 | 200820_at | -0.0180 | 0.9287 | |
| GSE53622 | PSMD8 | 5714 | 63861 | 0.2069 | 0.0075 | |
| GSE53624 | PSMD8 | 5714 | 63861 | 0.2289 | 0.0001 | |
| GSE63941 | PSMD8 | 5714 | 200820_at | 0.2088 | 0.7055 | |
| GSE77861 | PSMD8 | 5714 | 200820_at | 0.2179 | 0.3039 | |
| GSE97050 | PSMD8 | 5714 | A_23_P67466 | 0.1673 | 0.4585 | |
| SRP007169 | PSMD8 | 5714 | RNAseq | -0.3176 | 0.5190 | |
| SRP008496 | PSMD8 | 5714 | RNAseq | -0.6109 | 0.0425 | |
| SRP064894 | PSMD8 | 5714 | RNAseq | 0.3422 | 0.1994 | |
| SRP133303 | PSMD8 | 5714 | RNAseq | 0.5513 | 0.0203 | |
| SRP159526 | PSMD8 | 5714 | RNAseq | 0.2212 | 0.2664 | |
| SRP193095 | PSMD8 | 5714 | RNAseq | -0.2251 | 0.0752 | |
| SRP219564 | PSMD8 | 5714 | RNAseq | -0.1825 | 0.5644 | |
| TCGA | PSMD8 | 5714 | RNAseq | 0.1099 | 0.0211 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PSMD8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMD8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMD8 | 5714 | 7 | 4 | 19 | |
| GSE20123 | PSMD8 | 5714 | 7 | 3 | 20 | |
| GSE43470 | PSMD8 | 5714 | 4 | 10 | 29 | |
| GSE46452 | PSMD8 | 5714 | 47 | 2 | 10 | |
| GSE47630 | PSMD8 | 5714 | 9 | 5 | 26 | |
| GSE54993 | PSMD8 | 5714 | 17 | 3 | 50 | |
| GSE54994 | PSMD8 | 5714 | 6 | 9 | 38 | |
| GSE60625 | PSMD8 | 5714 | 9 | 0 | 2 | |
| GSE74703 | PSMD8 | 5714 | 4 | 6 | 26 | |
| GSE74704 | PSMD8 | 5714 | 7 | 1 | 12 | |
| TCGA | PSMD8 | 5714 | 16 | 15 | 65 |
Total number of gains: 133; Total number of losses: 58; Total Number of normals: 297.
Somatic mutations of PSMD8:
Generating mutation plots.
Highly correlated genes for PSMD8:
Showing top 20/398 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMD8 | FBXL5 | 0.82309 | 3 | 0 | 3 |
| PSMD8 | NAGA | 0.798649 | 3 | 0 | 3 |
| PSMD8 | HERPUD1 | 0.786122 | 3 | 0 | 3 |
| PSMD8 | VPS25 | 0.776186 | 3 | 0 | 3 |
| PSMD8 | CCNI | 0.770487 | 3 | 0 | 3 |
| PSMD8 | ELF1 | 0.766753 | 3 | 0 | 3 |
| PSMD8 | SORL1 | 0.744455 | 3 | 0 | 3 |
| PSMD8 | VDAC3 | 0.743882 | 3 | 0 | 3 |
| PSMD8 | RPL19 | 0.741246 | 3 | 0 | 3 |
| PSMD8 | SUCLG2 | 0.740135 | 3 | 0 | 3 |
| PSMD8 | TRAM1 | 0.734021 | 3 | 0 | 3 |
| PSMD8 | UBE2J1 | 0.732775 | 4 | 0 | 4 |
| PSMD8 | TNKS2 | 0.732635 | 3 | 0 | 3 |
| PSMD8 | SCAMP2 | 0.731096 | 3 | 0 | 3 |
| PSMD8 | RBM3 | 0.728406 | 3 | 0 | 3 |
| PSMD8 | ARCN1 | 0.724669 | 4 | 0 | 4 |
| PSMD8 | PLEKHM1 | 0.724175 | 3 | 0 | 3 |
| PSMD8 | SEC24D | 0.723029 | 3 | 0 | 3 |
| PSMD8 | TMEM165 | 0.719234 | 3 | 0 | 3 |
| PSMD8 | FUCA1 | 0.717224 | 3 | 0 | 3 |
For details and further investigation, click here
