| Full name: ADP ribosylation factor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p14.3 | ||
| Entrez ID: 378 | HGNC ID: HGNC:655 | Ensembl Gene: ENSG00000168374 | OMIM ID: 601177 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ARF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARF4 | 378 | 201097_s_at | -0.0801 | 0.7353 | |
| GSE20347 | ARF4 | 378 | 201097_s_at | -0.3034 | 0.0747 | |
| GSE23400 | ARF4 | 378 | 201097_s_at | -0.0268 | 0.6627 | |
| GSE26886 | ARF4 | 378 | 201097_s_at | -0.9680 | 0.0000 | |
| GSE29001 | ARF4 | 378 | 201097_s_at | -0.1370 | 0.4191 | |
| GSE38129 | ARF4 | 378 | 201097_s_at | -0.1429 | 0.2717 | |
| GSE45670 | ARF4 | 378 | 201097_s_at | -0.0448 | 0.7008 | |
| GSE53622 | ARF4 | 378 | 55386 | -0.0484 | 0.4390 | |
| GSE53624 | ARF4 | 378 | 22721 | -0.0312 | 0.5872 | |
| GSE63941 | ARF4 | 378 | 201097_s_at | -1.5402 | 0.0021 | |
| GSE77861 | ARF4 | 378 | 201097_s_at | -0.4568 | 0.0038 | |
| GSE97050 | ARF4 | 378 | A_23_P431789 | 0.2917 | 0.4438 | |
| SRP007169 | ARF4 | 378 | RNAseq | -1.1355 | 0.0006 | |
| SRP008496 | ARF4 | 378 | RNAseq | -0.6249 | 0.0039 | |
| SRP064894 | ARF4 | 378 | RNAseq | -0.2225 | 0.1520 | |
| SRP133303 | ARF4 | 378 | RNAseq | 0.1847 | 0.3696 | |
| SRP159526 | ARF4 | 378 | RNAseq | -0.4263 | 0.0548 | |
| SRP193095 | ARF4 | 378 | RNAseq | -0.5703 | 0.0002 | |
| SRP219564 | ARF4 | 378 | RNAseq | -0.0112 | 0.9761 | |
| TCGA | ARF4 | 378 | RNAseq | -0.1354 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ARF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARF4 | 378 | 0 | 17 | 13 | |
| GSE20123 | ARF4 | 378 | 0 | 18 | 12 | |
| GSE43470 | ARF4 | 378 | 0 | 17 | 26 | |
| GSE46452 | ARF4 | 378 | 2 | 17 | 40 | |
| GSE47630 | ARF4 | 378 | 1 | 24 | 15 | |
| GSE54993 | ARF4 | 378 | 6 | 2 | 62 | |
| GSE54994 | ARF4 | 378 | 0 | 32 | 21 | |
| GSE60625 | ARF4 | 378 | 5 | 0 | 6 | |
| GSE74703 | ARF4 | 378 | 0 | 14 | 22 | |
| GSE74704 | ARF4 | 378 | 0 | 11 | 9 | |
| TCGA | ARF4 | 378 | 0 | 79 | 17 |
Total number of gains: 14; Total number of losses: 231; Total Number of normals: 243.
Somatic mutations of ARF4:
Generating mutation plots.
Highly correlated genes for ARF4:
Showing top 20/783 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARF4 | ZNF521 | 0.80857 | 3 | 0 | 3 |
| ARF4 | PRSS3 | 0.797537 | 3 | 0 | 3 |
| ARF4 | HOPX | 0.769288 | 3 | 0 | 3 |
| ARF4 | RAB10 | 0.76432 | 3 | 0 | 3 |
| ARF4 | TMEM234 | 0.760635 | 4 | 0 | 4 |
| ARF4 | HMGN1 | 0.759985 | 3 | 0 | 3 |
| ARF4 | LYNX1 | 0.755931 | 3 | 0 | 3 |
| ARF4 | CYSRT1 | 0.750804 | 3 | 0 | 3 |
| ARF4 | SPAG17 | 0.749932 | 3 | 0 | 3 |
| ARF4 | ANXA9 | 0.748888 | 3 | 0 | 3 |
| ARF4 | A2ML1 | 0.748012 | 3 | 0 | 3 |
| ARF4 | TGM1 | 0.746157 | 3 | 0 | 3 |
| ARF4 | FIBIN | 0.745067 | 3 | 0 | 3 |
| ARF4 | PANK2 | 0.743494 | 3 | 0 | 3 |
| ARF4 | KRT78 | 0.735759 | 3 | 0 | 3 |
| ARF4 | STAU2 | 0.733323 | 4 | 0 | 4 |
| ARF4 | SAMD5 | 0.731462 | 3 | 0 | 3 |
| ARF4 | MBNL3 | 0.731106 | 3 | 0 | 3 |
| ARF4 | RRAGD | 0.723577 | 3 | 0 | 3 |
| ARF4 | ATP13A4 | 0.720279 | 3 | 0 | 3 |
For details and further investigation, click here
