| Full name: RAP1B, member of RAS oncogene family | Alias Symbol: K-REV|RAL1B|DKFZp586H0723 | ||
| Type: protein-coding gene | Cytoband: 12q15 | ||
| Entrez ID: 5908 | HGNC ID: HGNC:9857 | Ensembl Gene: ENSG00000127314 | OMIM ID: 179530 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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RAP1B involved pathways:
Expression of RAP1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAP1B | 5908 | 200833_s_at | 0.2869 | 0.4907 | |
| GSE20347 | RAP1B | 5908 | 200833_s_at | 0.4570 | 0.0013 | |
| GSE23400 | RAP1B | 5908 | 200833_s_at | 0.6258 | 0.0000 | |
| GSE26886 | RAP1B | 5908 | 200833_s_at | -0.0290 | 0.8958 | |
| GSE29001 | RAP1B | 5908 | 200833_s_at | 0.4441 | 0.0702 | |
| GSE38129 | RAP1B | 5908 | 200833_s_at | 0.5173 | 0.0003 | |
| GSE45670 | RAP1B | 5908 | 200833_s_at | 0.1883 | 0.1650 | |
| GSE53622 | RAP1B | 5908 | 50120 | 0.2862 | 0.0000 | |
| GSE53624 | RAP1B | 5908 | 50120 | 0.6822 | 0.0000 | |
| GSE63941 | RAP1B | 5908 | 200833_s_at | -0.3137 | 0.5596 | |
| GSE77861 | RAP1B | 5908 | 200833_s_at | 0.7625 | 0.0026 | |
| GSE97050 | RAP1B | 5908 | A_23_P2661 | 0.0913 | 0.7345 | |
| SRP007169 | RAP1B | 5908 | RNAseq | 0.8126 | 0.0098 | |
| SRP008496 | RAP1B | 5908 | RNAseq | 1.0564 | 0.0000 | |
| SRP064894 | RAP1B | 5908 | RNAseq | 0.5871 | 0.0004 | |
| SRP133303 | RAP1B | 5908 | RNAseq | 0.7517 | 0.0000 | |
| SRP159526 | RAP1B | 5908 | RNAseq | 0.7975 | 0.0466 | |
| SRP193095 | RAP1B | 5908 | RNAseq | 0.2665 | 0.0245 | |
| SRP219564 | RAP1B | 5908 | RNAseq | 1.2135 | 0.0634 | |
| TCGA | RAP1B | 5908 | RNAseq | 0.1175 | 0.0381 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RAP1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAP1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAP1B | 5908 | 6 | 1 | 23 | |
| GSE20123 | RAP1B | 5908 | 6 | 0 | 24 | |
| GSE43470 | RAP1B | 5908 | 5 | 0 | 38 | |
| GSE46452 | RAP1B | 5908 | 13 | 0 | 46 | |
| GSE47630 | RAP1B | 5908 | 10 | 1 | 29 | |
| GSE54993 | RAP1B | 5908 | 0 | 8 | 62 | |
| GSE54994 | RAP1B | 5908 | 7 | 1 | 45 | |
| GSE60625 | RAP1B | 5908 | 0 | 0 | 11 | |
| GSE74703 | RAP1B | 5908 | 5 | 0 | 31 | |
| GSE74704 | RAP1B | 5908 | 5 | 0 | 15 | |
| TCGA | RAP1B | 5908 | 23 | 9 | 64 |
Total number of gains: 80; Total number of losses: 20; Total Number of normals: 388.
Somatic mutations of RAP1B:
Generating mutation plots.
Highly correlated genes for RAP1B:
Showing top 20/1222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAP1B | SDHAF2 | 0.802198 | 3 | 0 | 3 |
| RAP1B | ATXN1L | 0.722938 | 3 | 0 | 3 |
| RAP1B | SESTD1 | 0.722858 | 3 | 0 | 3 |
| RAP1B | UBXN7 | 0.719408 | 3 | 0 | 3 |
| RAP1B | MRPL10 | 0.719229 | 4 | 0 | 3 |
| RAP1B | DUS3L | 0.715568 | 3 | 0 | 3 |
| RAP1B | CCT2 | 0.71525 | 11 | 0 | 10 |
| RAP1B | TMEM181 | 0.711514 | 3 | 0 | 3 |
| RAP1B | FADS1 | 0.711358 | 3 | 0 | 3 |
| RAP1B | ATXN10 | 0.707798 | 3 | 0 | 3 |
| RAP1B | SPOPL | 0.707575 | 3 | 0 | 3 |
| RAP1B | LCLAT1 | 0.707252 | 5 | 0 | 4 |
| RAP1B | TLK2 | 0.702107 | 4 | 0 | 3 |
| RAP1B | MSTO1 | 0.700297 | 3 | 0 | 3 |
| RAP1B | DDB1 | 0.698186 | 4 | 0 | 3 |
| RAP1B | DEXI | 0.697268 | 4 | 0 | 3 |
| RAP1B | DHX8 | 0.695762 | 3 | 0 | 3 |
| RAP1B | MRPS5 | 0.694135 | 3 | 0 | 3 |
| RAP1B | GORAB | 0.692124 | 5 | 0 | 5 |
| RAP1B | YWHAG | 0.691381 | 4 | 0 | 3 |
For details and further investigation, click here
