PHF6

 

Full name: PHD finger protein 6 Alias Symbol: KIAA1823|MGC14797|CENP-31
Type: protein-coding gene Cytoband: Xq26.2
Entrez ID: 84295 HGNC ID: HGNC:18145 Ensembl Gene: ENSG00000156531 OMIM ID: 300414
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PHF6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PHF6 84295 225501_at 0.3044 0.3460
GSE26886 PHF6 84295 225501_at 0.0735 0.7356
GSE45670 PHF6 84295 225501_at 0.2602 0.1619
GSE63941 PHF6 84295 225501_at 0.1804 0.6585
GSE77861 PHF6 84295 225501_at -0.0072 0.9744
GSE97050 PHF6 84295 A_23_P171385 0.7287 0.1450
SRP007169 PHF6 84295 RNAseq 0.1041 0.8315
SRP008496 PHF6 84295 RNAseq 0.4997 0.1033
SRP064894 PHF6 84295 RNAseq 0.2948 0.2542
SRP133303 PHF6 84295 RNAseq 0.6175 0.0017
SRP159526 PHF6 84295 RNAseq 0.1192 0.6537
SRP193095 PHF6 84295 RNAseq 0.1603 0.1447
SRP219564 PHF6 84295 RNAseq 0.2726 0.5012
TCGA PHF6 84295 RNAseq 0.2344 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PHF6 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of PHF6:

 

No record found for this gene.

 

Somatic mutations of PHF6:

 

Generating mutation plots.

 

Highly correlated genes for PHF6:

 

Showing top 20/218 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PHF6CHAMP10.800303303
PHF6SLC33A10.777337303
PHF6IFT800.772819303
PHF6TMTC40.760628303
PHF6SRPK10.754628303
PHF6TPM30.75395303
PHF6BRCA20.741418303
PHF6TIMELESS0.739652303
PHF6XPNPEP10.739437303
PHF6KIF150.735176303
PHF6TTF20.73487303
PHF6NCAPD30.72446303
PHF6SMAD10.723878303
PHF6HMGB30.723865303
PHF6ZNF6440.721719303
PHF6GMCL10.717602303
PHF6SFT2D20.717443303
PHF6EML40.713314404
PHF6RBL10.712763303
PHF6TOMM50.712746303

For details and further investigation, click here