| Full name: ataxin 2 | Alias Symbol: ATX2 | ||
| Type: protein-coding gene | Cytoband: 12q24.12 | ||
| Entrez ID: 6311 | HGNC ID: HGNC:10555 | Ensembl Gene: ENSG00000204842 | OMIM ID: 601517 |
| Drug and gene relationship at DGIdb | |||
Expression of ATXN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATXN2 | 6311 | 202622_s_at | 0.1520 | 0.6528 | |
| GSE20347 | ATXN2 | 6311 | 202622_s_at | 0.0026 | 0.9800 | |
| GSE23400 | ATXN2 | 6311 | 202622_s_at | -0.1285 | 0.0226 | |
| GSE26886 | ATXN2 | 6311 | 202622_s_at | 0.2401 | 0.2094 | |
| GSE29001 | ATXN2 | 6311 | 202622_s_at | -0.1095 | 0.5252 | |
| GSE38129 | ATXN2 | 6311 | 202622_s_at | -0.1572 | 0.1847 | |
| GSE45670 | ATXN2 | 6311 | 202622_s_at | -0.2189 | 0.0028 | |
| GSE53622 | ATXN2 | 6311 | 15499 | -0.0477 | 0.4208 | |
| GSE53624 | ATXN2 | 6311 | 15499 | 0.0259 | 0.6544 | |
| GSE63941 | ATXN2 | 6311 | 202622_s_at | 0.0426 | 0.8883 | |
| GSE77861 | ATXN2 | 6311 | 202622_s_at | 0.3116 | 0.1164 | |
| GSE97050 | ATXN2 | 6311 | A_23_P389907 | -0.2084 | 0.4796 | |
| SRP007169 | ATXN2 | 6311 | RNAseq | 0.4893 | 0.1770 | |
| SRP008496 | ATXN2 | 6311 | RNAseq | 0.2840 | 0.2536 | |
| SRP064894 | ATXN2 | 6311 | RNAseq | 0.0482 | 0.7686 | |
| SRP133303 | ATXN2 | 6311 | RNAseq | 0.1395 | 0.2899 | |
| SRP159526 | ATXN2 | 6311 | RNAseq | 0.0357 | 0.8585 | |
| SRP193095 | ATXN2 | 6311 | RNAseq | 0.1234 | 0.2505 | |
| SRP219564 | ATXN2 | 6311 | RNAseq | -0.0911 | 0.7289 | |
| TCGA | ATXN2 | 6311 | RNAseq | -0.0871 | 0.0639 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATXN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATXN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATXN2 | 6311 | 5 | 3 | 22 | |
| GSE20123 | ATXN2 | 6311 | 5 | 3 | 22 | |
| GSE43470 | ATXN2 | 6311 | 2 | 1 | 40 | |
| GSE46452 | ATXN2 | 6311 | 9 | 1 | 49 | |
| GSE47630 | ATXN2 | 6311 | 9 | 3 | 28 | |
| GSE54993 | ATXN2 | 6311 | 0 | 5 | 65 | |
| GSE54994 | ATXN2 | 6311 | 4 | 2 | 47 | |
| GSE60625 | ATXN2 | 6311 | 0 | 0 | 11 | |
| GSE74703 | ATXN2 | 6311 | 2 | 0 | 34 | |
| GSE74704 | ATXN2 | 6311 | 2 | 2 | 16 | |
| TCGA | ATXN2 | 6311 | 22 | 12 | 62 |
Total number of gains: 60; Total number of losses: 32; Total Number of normals: 396.
Somatic mutations of ATXN2:
Generating mutation plots.
Highly correlated genes for ATXN2:
Showing top 20/428 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATXN2 | EEF1D | 0.776515 | 3 | 0 | 3 |
| ATXN2 | MAPRE2 | 0.75431 | 3 | 0 | 3 |
| ATXN2 | CALML4 | 0.749312 | 3 | 0 | 3 |
| ATXN2 | GNG7 | 0.745492 | 3 | 0 | 3 |
| ATXN2 | NAF1 | 0.738792 | 3 | 0 | 3 |
| ATXN2 | FAM210B | 0.738612 | 3 | 0 | 3 |
| ATXN2 | SLC16A4 | 0.727586 | 3 | 0 | 3 |
| ATXN2 | PDCD5 | 0.72545 | 3 | 0 | 3 |
| ATXN2 | GPRASP1 | 0.713032 | 4 | 0 | 3 |
| ATXN2 | MEPCE | 0.709906 | 3 | 0 | 3 |
| ATXN2 | ABCA6 | 0.695878 | 4 | 0 | 4 |
| ATXN2 | TTC14 | 0.692291 | 3 | 0 | 3 |
| ATXN2 | RHOBTB1 | 0.692269 | 3 | 0 | 3 |
| ATXN2 | ZNF830 | 0.691043 | 3 | 0 | 3 |
| ATXN2 | FLNC | 0.69083 | 4 | 0 | 3 |
| ATXN2 | CLCN7 | 0.688892 | 3 | 0 | 3 |
| ATXN2 | C7 | 0.68784 | 4 | 0 | 3 |
| ATXN2 | CILP | 0.686774 | 4 | 0 | 3 |
| ATXN2 | U2AF2 | 0.685057 | 3 | 0 | 3 |
| ATXN2 | CHRDL1 | 0.684409 | 4 | 0 | 4 |
For details and further investigation, click here
