| Full name: activator of transcription and developmental regulator AUTS2 | Alias Symbol: KIAA0442|FBRSL2 | ||
| Type: protein-coding gene | Cytoband: 7q11.22 | ||
| Entrez ID: 26053 | HGNC ID: HGNC:14262 | Ensembl Gene: ENSG00000158321 | OMIM ID: 607270 |
| Drug and gene relationship at DGIdb | |||
Expression of AUTS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AUTS2 | 26053 | 212599_at | 0.4677 | 0.6026 | |
| GSE20347 | AUTS2 | 26053 | 212599_at | 0.3462 | 0.2862 | |
| GSE23400 | AUTS2 | 26053 | 212599_at | 0.6234 | 0.0000 | |
| GSE26886 | AUTS2 | 26053 | 212599_at | 0.5646 | 0.0842 | |
| GSE29001 | AUTS2 | 26053 | 212599_at | 0.5953 | 0.0677 | |
| GSE38129 | AUTS2 | 26053 | 212599_at | 0.1408 | 0.6391 | |
| GSE45670 | AUTS2 | 26053 | 212599_at | 0.0712 | 0.8421 | |
| GSE53622 | AUTS2 | 26053 | 39877 | -0.4782 | 0.0000 | |
| GSE53624 | AUTS2 | 26053 | 39877 | -0.3065 | 0.0004 | |
| GSE63941 | AUTS2 | 26053 | 212599_at | -0.7920 | 0.5464 | |
| GSE77861 | AUTS2 | 26053 | 212599_at | 0.2039 | 0.5237 | |
| GSE97050 | AUTS2 | 26053 | A_33_P3330211 | -0.3095 | 0.3275 | |
| SRP007169 | AUTS2 | 26053 | RNAseq | 1.9285 | 0.0004 | |
| SRP008496 | AUTS2 | 26053 | RNAseq | 2.1774 | 0.0000 | |
| SRP064894 | AUTS2 | 26053 | RNAseq | 0.1504 | 0.5048 | |
| SRP133303 | AUTS2 | 26053 | RNAseq | 0.3530 | 0.0126 | |
| SRP159526 | AUTS2 | 26053 | RNAseq | 0.6320 | 0.0382 | |
| SRP193095 | AUTS2 | 26053 | RNAseq | 0.5248 | 0.0092 | |
| SRP219564 | AUTS2 | 26053 | RNAseq | 0.2433 | 0.6039 | |
| TCGA | AUTS2 | 26053 | RNAseq | 0.0548 | 0.4527 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by AUTS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AUTS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AUTS2 | 26053 | 10 | 2 | 18 | |
| GSE20123 | AUTS2 | 26053 | 9 | 2 | 19 | |
| GSE43470 | AUTS2 | 26053 | 3 | 1 | 39 | |
| GSE46452 | AUTS2 | 26053 | 12 | 0 | 47 | |
| GSE47630 | AUTS2 | 26053 | 7 | 2 | 31 | |
| GSE54993 | AUTS2 | 26053 | 2 | 7 | 61 | |
| GSE54994 | AUTS2 | 26053 | 13 | 7 | 33 | |
| GSE60625 | AUTS2 | 26053 | 0 | 0 | 11 | |
| GSE74703 | AUTS2 | 26053 | 3 | 1 | 32 | |
| GSE74704 | AUTS2 | 26053 | 6 | 1 | 13 | |
| TCGA | AUTS2 | 26053 | 46 | 9 | 41 |
Total number of gains: 111; Total number of losses: 32; Total Number of normals: 345.
Somatic mutations of AUTS2:
Generating mutation plots.
Highly correlated genes for AUTS2:
Showing top 20/82 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AUTS2 | ZNF567 | 0.689577 | 3 | 0 | 3 |
| AUTS2 | FOXA1 | 0.684839 | 3 | 0 | 3 |
| AUTS2 | BTBD3 | 0.664239 | 7 | 0 | 6 |
| AUTS2 | PRKAR2B | 0.658865 | 3 | 0 | 3 |
| AUTS2 | GGPS1 | 0.64865 | 3 | 0 | 3 |
| AUTS2 | MAP7D2 | 0.632163 | 4 | 0 | 3 |
| AUTS2 | ACVR2B | 0.629729 | 4 | 0 | 4 |
| AUTS2 | TACC1 | 0.626176 | 4 | 0 | 4 |
| AUTS2 | USP51 | 0.62518 | 3 | 0 | 3 |
| AUTS2 | ZNF678 | 0.622362 | 4 | 0 | 3 |
| AUTS2 | SYNPO2 | 0.620924 | 3 | 0 | 3 |
| AUTS2 | AKAP1 | 0.619058 | 4 | 0 | 3 |
| AUTS2 | SCARA5 | 0.618754 | 3 | 0 | 3 |
| AUTS2 | FOXO6 | 0.618247 | 4 | 0 | 3 |
| AUTS2 | SPARCL1 | 0.613411 | 3 | 0 | 3 |
| AUTS2 | BMPR1A | 0.611733 | 5 | 0 | 4 |
| AUTS2 | PHIP | 0.609658 | 5 | 0 | 4 |
| AUTS2 | LRIG1 | 0.60704 | 5 | 0 | 3 |
| AUTS2 | TCTA | 0.604344 | 3 | 0 | 3 |
| AUTS2 | ZNF84 | 0.602914 | 6 | 0 | 4 |
For details and further investigation, click here
