PRKAR2B

 

Full name: protein kinase cAMP-dependent type II regulatory subunit beta Alias Symbol: 
Type: protein-coding gene Cytoband: 7q22.3
Entrez ID: 5577 HGNC ID: HGNC:9392 Ensembl Gene: ENSG00000005249 OMIM ID: 176912
Drug and gene relationship at DGIdb

 

PRKAR2B involved pathways:

KEGG pathway Description View
hsa04910Insulin signaling pathway

 

Expression of PRKAR2B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKAR2B 5577 203680_at -2.0141 0.2162
GSE20347 PRKAR2B 5577 203680_at -0.3759 0.5065
GSE23400 PRKAR2B 5577 203680_at -0.9610 0.0001
GSE26886 PRKAR2B 5577 203680_at 0.5716 0.4471
GSE29001 PRKAR2B 5577 203680_at -0.3909 0.5797
GSE38129 PRKAR2B 5577 203680_at -1.3769 0.0142
GSE45670 PRKAR2B 5577 203680_at -2.9533 0.0000
GSE53622 PRKAR2B 5577 60361 -1.2784 0.0000
GSE53624 PRKAR2B 5577 60361 -0.8879 0.0000
GSE63941 PRKAR2B 5577 203680_at -4.8853 0.0035
GSE77861 PRKAR2B 5577 203680_at 0.5774 0.1588
GSE97050 PRKAR2B 5577 A_33_P3304983 -0.9054 0.1692
SRP007169 PRKAR2B 5577 RNAseq 0.2225 0.7168
SRP064894 PRKAR2B 5577 RNAseq -1.1641 0.0020
SRP133303 PRKAR2B 5577 RNAseq -1.1206 0.0022
SRP159526 PRKAR2B 5577 RNAseq -0.5804 0.0880
SRP193095 PRKAR2B 5577 RNAseq 0.2296 0.4811
SRP219564 PRKAR2B 5577 RNAseq -0.4636 0.6376
TCGA PRKAR2B 5577 RNAseq -0.7352 0.0002

Upregulated datasets: 0; Downregulated datasets: 6.  

 

Survival by PRKAR2B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKAR2B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKAR2B 5577 12 0 18
GSE20123 PRKAR2B 5577 12 0 18
GSE43470 PRKAR2B 5577 6 2 35
GSE46452 PRKAR2B 5577 10 1 48
GSE47630 PRKAR2B 5577 8 3 29
GSE54993 PRKAR2B 5577 3 8 59
GSE54994 PRKAR2B 5577 16 3 34
GSE60625 PRKAR2B 5577 0 0 11
GSE74703 PRKAR2B 5577 6 2 28
GSE74704 PRKAR2B 5577 8 0 12
TCGA PRKAR2B 5577 50 10 36

Total number of gains: 131; Total number of losses: 29; Total Number of normals: 328.  

 

Somatic mutations of PRKAR2B:

 

Generating mutation plots.

 

Highly correlated genes for PRKAR2B:

 

Showing top 20/1228 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKAR2BAFF30.839461303
PRKAR2BUBXN100.828904303
PRKAR2BSYNPO20.827697808
PRKAR2BITGA70.813292909
PRKAR2BPDE5A0.81326909
PRKAR2BBHMT20.8126909
PRKAR2BC3orf700.811813707
PRKAR2BNEGR10.8091606
PRKAR2BCBX70.805823908
PRKAR2BFXYD10.802011606
PRKAR2BRNF1500.801166707
PRKAR2BSORCS10.798877404
PRKAR2BLONRF20.798013505
PRKAR2BMAMDC20.797115606
PRKAR2BFIBIN0.793107404
PRKAR2BFENDRR0.792475505
PRKAR2BTCEAL20.7913851009
PRKAR2BFILIP10.791022505
PRKAR2BLMOD10.78319311011
PRKAR2BLINC012790.780894404

For details and further investigation, click here