| Full name: transforming acidic coiled-coil containing protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p11.22 | ||
| Entrez ID: 6867 | HGNC ID: HGNC:11522 | Ensembl Gene: ENSG00000147526 | OMIM ID: 605301 |
| Drug and gene relationship at DGIdb | |||
Expression of TACC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TACC1 | 6867 | 200911_s_at | -1.0069 | 0.2868 | |
| GSE20347 | TACC1 | 6867 | 200911_s_at | -0.1716 | 0.5654 | |
| GSE23400 | TACC1 | 6867 | 200911_s_at | -0.5439 | 0.0001 | |
| GSE26886 | TACC1 | 6867 | 200911_s_at | -1.1131 | 0.0001 | |
| GSE29001 | TACC1 | 6867 | 200911_s_at | -0.6646 | 0.0462 | |
| GSE38129 | TACC1 | 6867 | 200911_s_at | -0.7489 | 0.0039 | |
| GSE45670 | TACC1 | 6867 | 200911_s_at | -1.2223 | 0.0000 | |
| GSE53622 | TACC1 | 6867 | 114777 | -1.3431 | 0.0000 | |
| GSE53624 | TACC1 | 6867 | 114777 | -1.1891 | 0.0000 | |
| GSE63941 | TACC1 | 6867 | 200911_s_at | -1.8520 | 0.0802 | |
| GSE77861 | TACC1 | 6867 | 200911_s_at | -0.1501 | 0.6828 | |
| GSE97050 | TACC1 | 6867 | A_24_P98249 | -0.9914 | 0.0903 | |
| SRP007169 | TACC1 | 6867 | RNAseq | -0.0465 | 0.9043 | |
| SRP008496 | TACC1 | 6867 | RNAseq | -0.0255 | 0.9206 | |
| SRP064894 | TACC1 | 6867 | RNAseq | -0.7923 | 0.0190 | |
| SRP133303 | TACC1 | 6867 | RNAseq | -0.3760 | 0.2459 | |
| SRP159526 | TACC1 | 6867 | RNAseq | -1.0922 | 0.0000 | |
| SRP193095 | TACC1 | 6867 | RNAseq | -0.2248 | 0.0680 | |
| SRP219564 | TACC1 | 6867 | RNAseq | -0.5013 | 0.5374 | |
| TCGA | TACC1 | 6867 | RNAseq | -0.3937 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by TACC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TACC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TACC1 | 6867 | 10 | 4 | 16 | |
| GSE20123 | TACC1 | 6867 | 10 | 4 | 16 | |
| GSE43470 | TACC1 | 6867 | 8 | 6 | 29 | |
| GSE46452 | TACC1 | 6867 | 21 | 5 | 33 | |
| GSE47630 | TACC1 | 6867 | 12 | 7 | 21 | |
| GSE54993 | TACC1 | 6867 | 2 | 16 | 52 | |
| GSE54994 | TACC1 | 6867 | 16 | 7 | 30 | |
| GSE60625 | TACC1 | 6867 | 3 | 0 | 8 | |
| GSE74703 | TACC1 | 6867 | 8 | 5 | 23 | |
| GSE74704 | TACC1 | 6867 | 9 | 1 | 10 | |
| TCGA | TACC1 | 6867 | 37 | 21 | 38 |
Total number of gains: 136; Total number of losses: 76; Total Number of normals: 276.
Somatic mutations of TACC1:
Generating mutation plots.
Highly correlated genes for TACC1:
Showing top 20/1004 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TACC1 | SENP8 | 0.80674 | 3 | 0 | 3 |
| TACC1 | MYZAP | 0.789042 | 3 | 0 | 3 |
| TACC1 | RBFOX3 | 0.785946 | 3 | 0 | 3 |
| TACC1 | XKR4 | 0.759143 | 5 | 0 | 5 |
| TACC1 | PPP1R12B | 0.753457 | 9 | 0 | 9 |
| TACC1 | SORCS1 | 0.748601 | 4 | 0 | 4 |
| TACC1 | PLAC9 | 0.748151 | 5 | 0 | 5 |
| TACC1 | CYP21A2 | 0.743041 | 3 | 0 | 3 |
| TACC1 | VMAC | 0.737989 | 3 | 0 | 3 |
| TACC1 | PRUNE2 | 0.732277 | 10 | 0 | 10 |
| TACC1 | PTCHD1 | 0.731892 | 5 | 0 | 5 |
| TACC1 | GOLGA4 | 0.729103 | 3 | 0 | 3 |
| TACC1 | ATP1A2 | 0.728642 | 9 | 0 | 7 |
| TACC1 | FAM107A | 0.728271 | 8 | 0 | 7 |
| TACC1 | ACTBL2 | 0.727351 | 3 | 0 | 3 |
| TACC1 | CASQ2 | 0.727333 | 8 | 0 | 8 |
| TACC1 | SH3BGRL2 | 0.726376 | 5 | 0 | 5 |
| TACC1 | LINC01279 | 0.723478 | 3 | 0 | 3 |
| TACC1 | TNS1 | 0.722496 | 9 | 0 | 8 |
| TACC1 | AQP1 | 0.721159 | 10 | 0 | 9 |
For details and further investigation, click here
