FOXA1

 

Full name: forkhead box A1 Alias Symbol: 
Type: protein-coding gene Cytoband: 14q21.1
Entrez ID: 3169 HGNC ID: HGNC:5021 Ensembl Gene: ENSG00000129514 OMIM ID: 602294
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 14/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of FOXA1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FOXA1 3169 204667_at -0.4868 0.7958
GSE20347 FOXA1 3169 204667_at -0.0447 0.9040
GSE23400 FOXA1 3169 204667_at -0.0817 0.4981
GSE26886 FOXA1 3169 204667_at -0.9299 0.0055
GSE29001 FOXA1 3169 204667_at -1.0101 0.0292
GSE38129 FOXA1 3169 204667_at 0.0246 0.9422
GSE45670 FOXA1 3169 204667_at -0.2002 0.7203
GSE53622 FOXA1 3169 29526 -1.1688 0.0000
GSE53624 FOXA1 3169 29526 -1.6120 0.0000
GSE63941 FOXA1 3169 204667_at 2.6106 0.0585
GSE77861 FOXA1 3169 204667_at -0.4957 0.0427
GSE97050 FOXA1 3169 A_33_P3332997 -0.4439 0.3612
SRP007169 FOXA1 3169 RNAseq -0.5485 0.5558
SRP008496 FOXA1 3169 RNAseq -0.5809 0.4017
SRP064894 FOXA1 3169 RNAseq -0.8567 0.1882
SRP133303 FOXA1 3169 RNAseq 0.7353 0.3379
SRP159526 FOXA1 3169 RNAseq -0.1638 0.8073
SRP193095 FOXA1 3169 RNAseq -0.6442 0.0647
SRP219564 FOXA1 3169 RNAseq 0.0199 0.9855
TCGA FOXA1 3169 RNAseq -0.5524 0.0759

Upregulated datasets: 0; Downregulated datasets: 3.  

 

Survival by FOXA1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FOXA1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FOXA1 3169 11 5 14
GSE20123 FOXA1 3169 12 5 13
GSE43470 FOXA1 3169 8 2 33
GSE46452 FOXA1 3169 18 2 39
GSE47630 FOXA1 3169 11 10 19
GSE54993 FOXA1 3169 3 9 58
GSE54994 FOXA1 3169 18 5 30
GSE60625 FOXA1 3169 0 2 9
GSE74703 FOXA1 3169 7 2 27
GSE74704 FOXA1 3169 6 4 10
TCGA FOXA1 3169 37 14 45

Total number of gains: 131; Total number of losses: 60; Total Number of normals: 297.  

 

Somatic mutations of FOXA1:

 

Generating mutation plots.

 

Highly correlated genes for FOXA1:

 

Showing top 20/251 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FOXA1CHCHD10.712328303
FOXA1FAF10.709197303
FOXA1MRPL430.694775303
FOXA1TTC60.690431505
FOXA1AUTS20.684839303
FOXA1MUC200.68255807
FOXA1AP3M10.679047303
FOXA1PRPF38A0.663766303
FOXA1CYP2E10.651102606
FOXA1ZNF1340.643078404
FOXA1ADIRF0.641705404
FOXA1SNX310.6389807
FOXA1RCHY10.637607403
FOXA1TRAPPC20.634566403
FOXA1ARHGEF260.630368404
FOXA1CHCHD50.624725303
FOXA1SOX21-AS10.617704605
FOXA1BST10.617544303
FOXA1PCSK20.614647404
FOXA1RPS120.614559303

For details and further investigation, click here