| Full name: metallo-beta-lactamase domain containing 1 | Alias Symbol: MGC49416 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 255374 | HGNC ID: HGNC:22180 | Ensembl Gene: ENSG00000214309 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of MBLAC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MBLAC1 | 255374 | 1554170_a_at | -0.1688 | 0.3798 | |
| GSE26886 | MBLAC1 | 255374 | 1554170_a_at | -0.0564 | 0.7717 | |
| GSE45670 | MBLAC1 | 255374 | 1554170_a_at | -0.0835 | 0.4699 | |
| GSE53622 | MBLAC1 | 255374 | 106349 | -0.3819 | 0.0000 | |
| GSE53624 | MBLAC1 | 255374 | 106349 | -0.5585 | 0.0000 | |
| GSE63941 | MBLAC1 | 255374 | 1554170_a_at | -0.3231 | 0.2037 | |
| GSE77861 | MBLAC1 | 255374 | 1554170_a_at | -0.0578 | 0.6125 | |
| GSE97050 | MBLAC1 | 255374 | A_24_P221198 | -0.0070 | 0.9857 | |
| SRP064894 | MBLAC1 | 255374 | RNAseq | -0.3593 | 0.3181 | |
| SRP133303 | MBLAC1 | 255374 | RNAseq | -0.5537 | 0.0275 | |
| SRP159526 | MBLAC1 | 255374 | RNAseq | 0.1582 | 0.7382 | |
| SRP219564 | MBLAC1 | 255374 | RNAseq | -0.5706 | 0.1538 | |
| TCGA | MBLAC1 | 255374 | RNAseq | 0.0605 | 0.6485 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MBLAC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MBLAC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MBLAC1 | 255374 | 13 | 0 | 17 | |
| GSE20123 | MBLAC1 | 255374 | 13 | 0 | 17 | |
| GSE43470 | MBLAC1 | 255374 | 6 | 2 | 35 | |
| GSE46452 | MBLAC1 | 255374 | 11 | 1 | 47 | |
| GSE47630 | MBLAC1 | 255374 | 7 | 3 | 30 | |
| GSE54993 | MBLAC1 | 255374 | 1 | 9 | 60 | |
| GSE54994 | MBLAC1 | 255374 | 15 | 3 | 35 | |
| GSE60625 | MBLAC1 | 255374 | 0 | 0 | 11 | |
| GSE74703 | MBLAC1 | 255374 | 6 | 1 | 29 | |
| GSE74704 | MBLAC1 | 255374 | 9 | 0 | 11 | |
| TCGA | MBLAC1 | 255374 | 52 | 6 | 38 |
Total number of gains: 133; Total number of losses: 25; Total Number of normals: 330.
Somatic mutations of MBLAC1:
Generating mutation plots.
Highly correlated genes for MBLAC1:
Showing top 20/197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MBLAC1 | PPP3CC | 0.770596 | 3 | 0 | 3 |
| MBLAC1 | GRIK2 | 0.769921 | 3 | 0 | 3 |
| MBLAC1 | SARDH | 0.751633 | 3 | 0 | 3 |
| MBLAC1 | IGBP1 | 0.728484 | 3 | 0 | 3 |
| MBLAC1 | WDR20 | 0.726483 | 3 | 0 | 3 |
| MBLAC1 | VSTM4 | 0.716814 | 3 | 0 | 3 |
| MBLAC1 | FGF1 | 0.698912 | 3 | 0 | 3 |
| MBLAC1 | HGF | 0.695714 | 3 | 0 | 3 |
| MBLAC1 | KRT72 | 0.687323 | 3 | 0 | 3 |
| MBLAC1 | ANKRD9 | 0.683682 | 3 | 0 | 3 |
| MBLAC1 | NAALADL1 | 0.680925 | 4 | 0 | 4 |
| MBLAC1 | AVPR1A | 0.67943 | 3 | 0 | 3 |
| MBLAC1 | FOXF1 | 0.67465 | 3 | 0 | 3 |
| MBLAC1 | FAM114A2 | 0.674539 | 3 | 0 | 3 |
| MBLAC1 | PPP1R15A | 0.670709 | 3 | 0 | 3 |
| MBLAC1 | PLEKHA4 | 0.669939 | 3 | 0 | 3 |
| MBLAC1 | UBE2D2 | 0.669729 | 4 | 0 | 3 |
| MBLAC1 | STK19 | 0.669429 | 3 | 0 | 3 |
| MBLAC1 | RALB | 0.668866 | 3 | 0 | 3 |
| MBLAC1 | APPL1 | 0.668504 | 3 | 0 | 3 |
For details and further investigation, click here
