| Full name: transmembrane protein 176B | Alias Symbol: LR8|MS4B2 | ||
| Type: protein-coding gene | Cytoband: 7q36.1 | ||
| Entrez ID: 28959 | HGNC ID: HGNC:29596 | Ensembl Gene: ENSG00000106565 | OMIM ID: 610385 |
| Drug and gene relationship at DGIdb | |||
Expression of TMEM176B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM176B | 28959 | 220532_s_at | -0.4369 | 0.7804 | |
| GSE20347 | TMEM176B | 28959 | 220532_s_at | 0.8911 | 0.0001 | |
| GSE23400 | TMEM176B | 28959 | 220532_s_at | 0.3491 | 0.0432 | |
| GSE26886 | TMEM176B | 28959 | 220532_s_at | -0.0220 | 0.9749 | |
| GSE29001 | TMEM176B | 28959 | 220532_s_at | 0.7050 | 0.0976 | |
| GSE38129 | TMEM176B | 28959 | 220532_s_at | 0.4898 | 0.3361 | |
| GSE45670 | TMEM176B | 28959 | 220532_s_at | -0.8078 | 0.0259 | |
| GSE53622 | TMEM176B | 28959 | 113228 | 0.2267 | 0.1306 | |
| GSE53624 | TMEM176B | 28959 | 113228 | 0.1545 | 0.4138 | |
| GSE63941 | TMEM176B | 28959 | 220532_s_at | -5.3815 | 0.0000 | |
| GSE77861 | TMEM176B | 28959 | 236348_at | -0.0643 | 0.7607 | |
| GSE97050 | TMEM176B | 28959 | A_23_P157007 | 0.7015 | 0.1581 | |
| SRP007169 | TMEM176B | 28959 | RNAseq | 2.7288 | 0.0000 | |
| SRP008496 | TMEM176B | 28959 | RNAseq | 2.2255 | 0.0000 | |
| SRP064894 | TMEM176B | 28959 | RNAseq | 0.5191 | 0.1657 | |
| SRP133303 | TMEM176B | 28959 | RNAseq | 0.4791 | 0.0983 | |
| SRP159526 | TMEM176B | 28959 | RNAseq | 0.1894 | 0.6895 | |
| SRP193095 | TMEM176B | 28959 | RNAseq | 0.8590 | 0.0489 | |
| SRP219564 | TMEM176B | 28959 | RNAseq | 0.9218 | 0.0835 | |
| TCGA | TMEM176B | 28959 | RNAseq | -0.1613 | 0.1155 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by TMEM176B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM176B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM176B | 28959 | 2 | 4 | 24 | |
| GSE20123 | TMEM176B | 28959 | 2 | 4 | 24 | |
| GSE43470 | TMEM176B | 28959 | 2 | 5 | 36 | |
| GSE46452 | TMEM176B | 28959 | 7 | 2 | 50 | |
| GSE47630 | TMEM176B | 28959 | 5 | 9 | 26 | |
| GSE54993 | TMEM176B | 28959 | 3 | 3 | 64 | |
| GSE54994 | TMEM176B | 28959 | 5 | 8 | 40 | |
| GSE60625 | TMEM176B | 28959 | 0 | 0 | 11 | |
| GSE74703 | TMEM176B | 28959 | 2 | 4 | 30 | |
| GSE74704 | TMEM176B | 28959 | 1 | 4 | 15 | |
| TCGA | TMEM176B | 28959 | 26 | 26 | 44 |
Total number of gains: 55; Total number of losses: 69; Total Number of normals: 364.
Somatic mutations of TMEM176B:
Generating mutation plots.
Highly correlated genes for TMEM176B:
Showing top 20/730 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM176B | MPEG1 | 0.804871 | 6 | 0 | 6 |
| TMEM176B | CD163 | 0.765172 | 10 | 0 | 9 |
| TMEM176B | GPC6 | 0.754838 | 6 | 0 | 6 |
| TMEM176B | GPR34 | 0.751559 | 6 | 0 | 6 |
| TMEM176B | TYROBP | 0.739965 | 11 | 0 | 11 |
| TMEM176B | C19orf38 | 0.736397 | 3 | 0 | 3 |
| TMEM176B | PIK3R6 | 0.731965 | 3 | 0 | 3 |
| TMEM176B | RCSD1 | 0.731115 | 6 | 0 | 6 |
| TMEM176B | CERKL | 0.728634 | 3 | 0 | 3 |
| TMEM176B | MRC1 | 0.728527 | 10 | 0 | 10 |
| TMEM176B | ITGAM | 0.725542 | 9 | 0 | 8 |
| TMEM176B | ARHGAP17 | 0.724553 | 3 | 0 | 3 |
| TMEM176B | SRGN | 0.724527 | 11 | 0 | 10 |
| TMEM176B | GIMAP5 | 0.724145 | 3 | 0 | 3 |
| TMEM176B | DNM3OS | 0.72272 | 3 | 0 | 3 |
| TMEM176B | C1QA | 0.70881 | 12 | 0 | 10 |
| TMEM176B | RARRES2 | 0.70799 | 10 | 0 | 9 |
| TMEM176B | CEP128 | 0.702209 | 3 | 0 | 3 |
| TMEM176B | FCER1G | 0.701257 | 10 | 0 | 10 |
| TMEM176B | LAPTM5 | 0.699444 | 11 | 0 | 10 |
For details and further investigation, click here
