IL6

 

Full name: interleukin 6 Alias Symbol: IL-6|BSF2|HGF|HSF
Type: protein-coding gene Cytoband: 7p15.3
Entrez ID: 3569 HGNC ID: HGNC:6018 Ensembl Gene: ENSG00000136244 OMIM ID: 147620
Drug and gene relationship at DGIdb

 

IL6 involved pathways:

KEGG pathway Description View
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05134Legionellosis
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05321Inflammatory bowel disease (IBD)

 

Expression of IL6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IL6 3569 205207_at -1.1358 0.5762
GSE20347 IL6 3569 205207_at 0.0583 0.8521
GSE23400 IL6 3569 205207_at -0.2072 0.1896
GSE26886 IL6 3569 205207_at 1.0589 0.0497
GSE29001 IL6 3569 205207_at 0.1029 0.8193
GSE38129 IL6 3569 205207_at -0.5645 0.2174
GSE45670 IL6 3569 205207_at -0.2518 0.7749
GSE53622 IL6 3569 75304 -0.3936 0.2323
GSE53624 IL6 3569 75304 -0.2177 0.4061
GSE63941 IL6 3569 205207_at -3.6488 0.0057
GSE77861 IL6 3569 205207_at 1.0530 0.0592
GSE97050 IL6 3569 A_23_P71037 0.5853 0.4062
SRP133303 IL6 3569 RNAseq 1.4297 0.0013
SRP219564 IL6 3569 RNAseq 0.0993 0.9221
TCGA IL6 3569 RNAseq -0.1297 0.6718

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by IL6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IL6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IL6 3569 17 1 12
GSE20123 IL6 3569 17 1 12
GSE43470 IL6 3569 4 0 39
GSE46452 IL6 3569 10 2 47
GSE47630 IL6 3569 9 1 30
GSE54993 IL6 3569 0 6 64
GSE54994 IL6 3569 20 2 31
GSE60625 IL6 3569 0 0 11
GSE74703 IL6 3569 4 0 32
GSE74704 IL6 3569 11 1 8
TCGA IL6 3569 56 4 36

Total number of gains: 148; Total number of losses: 18; Total Number of normals: 322.  

 

Somatic mutations of IL6:

 

Generating mutation plots.

 

Highly correlated genes for IL6:

 

Showing top 20/438 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IL6RND10.815386303
IL6CCL20.749484909
IL6SLC15A40.743147303
IL6C2CD4B0.734763404
IL6RAB8B0.722521404
IL6CHRM20.71728303
IL6COL11A10.708151303
IL6AVPR1A0.707436505
IL6GPR680.700542303
IL6TBC1D280.700281303
IL6ZFAND2A0.688357303
IL6GLA0.68578303
IL6PPP1R180.683163403
IL6C9orf470.67748404
IL6GDI10.671217403
IL6C11orf960.670937504
IL6FJX10.668303
IL6GAA0.665651303
IL6IFITM30.665479303
IL6NR4A10.664552707

For details and further investigation, click here